ChemicalBook > CAS DataBase List > 9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
- Product Name
- 9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
- CAS No.
- 2342583-66-6
- Chemical Name
- 9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
- Synonyms
- NCC007, 10 mM in DMSO;inhibit,NCC-007,Inhibitor,NCC007,NCC 007,Casein Kinase;9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine;9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]-
- CBNumber
- CB18245224
- Molecular Formula
- C22H28F3N7
- Formula Weight
- 447.5
- MOL File
- 2342583-66-6.mol
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9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Property
- Boiling point:
- 573.5±60.0 °C(Predicted)
- Density
- 1.36±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 9.02±0.28(Predicted)
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0097017
- Product name
- NCC007
- Purity
- 99.58%
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0097017
- Product name
- NCC007
- Purity
- 99.58%
- Packaging
- 10mg
- Price
- $150
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0097017
- Product name
- NCC007
- Purity
- 99.58%
- Packaging
- 25mg
- Price
- $250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0097017
- Product name
- NCC007
- Purity
- 99.58%
- Packaging
- 50mg
- Price
- $450
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0097017
- Product name
- NCC007
- Purity
- 99.58%
- Packaging
- 100mg
- Price
- $750
- Updated
- 2021/12/16
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9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Chemical Properties,Usage,Production
Biological Activity
NCC007 is a dual casein kinase Iα (CKIα) and delta (CKIδ) inhibitor with IC50 of 1.8 and 3.6 μM, respectively. It can be used for the study of mammalian circadian rhythms.
in vivo
NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.
| Animal Model: | Adult C57BL/6J background male mice (8 weeks old) |
| Dosage: | 5 , 15 mM |
| Administration: | Infused into the lateral ventricle, constant dark condition |
| Result: | Showed more period lengthening effect with 0.15 hours at 5 mM and 15 mM. | < /tr>
target
| CKIα 1.8 μM (IC 50 ) | CKIδ 3.6 μM (IC 50 ) |
9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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9H-Purine-2,6-diamine, 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-[[3-(trifluoromethyl)phenyl]methyl]- Suppliers
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