3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID
- Product Name
- 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID
- CAS No.
- 129765-95-3
- Chemical Name
- 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID
- Synonyms
- N-Boc-3-amino-3-methylbutanoic Acid;3-(tert-butoxycarbonyl)-3-Methylbutanoic acid;3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID;3-(tert-butoxycarbonylamino)-3-methylbutanoic acid;3-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-methylbutanoic acid;Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-;2-amino-3,3-dimethyl-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
- CBNumber
- CB1839894
- Molecular Formula
- C10H19NO4
- Formula Weight
- 217.26
- MOL File
- 129765-95-3.mol
3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID Property
- Boiling point:
- 346.5±25.0 °C(Predicted)
- Density
- 1.082±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.45±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H19NO4/c1-9(2,3)15-8(14)11-10(4,5)6-7(12)13/h6H2,1-5H3,(H,11,14)(H,12,13)
- InChIKey
- LHJVMOIOTPJSLS-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CC(NC(OC(C)(C)C)=O)(C)C
Safety
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809790
- Product name
- 3-((tert-Butoxycarbonyl)amino)-3-methylbutanoicAcid
- Packaging
- 5g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- BAA2150
- Product name
- Boc-3-amino-3-methyl-butyricacid
- Packaging
- 1g
- Price
- $216
- Updated
- 2021/12/16
- Product number
- FB43557
- Product name
- 3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid
- Packaging
- 10g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FB43557
- Product name
- 3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid
- Packaging
- 5G
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 092192
- Product name
- 3-(tert-Butoxycarbonylamino)-3-methylbutanoicacid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $29
- Updated
- 2021/12/16
3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic Acid is an intermediate used in the synthesis of (2E)-5-(tert-Butyloxycarbonylamino)-5-methylhex-2-enoic Acid (B809765), which is used in the preparation of C-terminal sulfonamide analogs of NN703 as growth hormone secretagogues.
Synthesis
625-05-8
24424-99-5
129765-95-3
Di-tert-butyl 3-amino-3-methylbutyrate (0.59 g, 5.04 mmol) and di-tert-butyl dicarbonate (1.228 mL, 5.29 mmol) were added to a 1 M potassium hydroxide solution (5.04 mL, 5.04 mmol) as a raw material after dissolving in dioxane (10 mL). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the dioxane was removed by distillation under reduced pressure. The residue was diluted with water (20 mL) and the pH was adjusted with lithium hydroxide to 13. Subsequently, the mixture was washed three times with ether. Next, the pH was adjusted to 3 with 2N hydrochloric acid to obtain a turbid solution. The solution was extracted four times with ethyl acetate and the combined organic phases were washed with a small amount of brine and dried with anhydrous sodium sulfate. Finally, N-Boc-3-amino-3-methylbutyric acid (860 mg, 3.96 mmol, 79% yield) was obtained as a crystalline solid by vacuum concentration.
References
[1] Patent: US2010/204274, 2010, A1. Location in patent: Page/Page column 30
[2] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 43
[3] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 98; 99
[4] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 321
[5] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 650
3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID manufacturers
- Product
- 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID 129765-95-3
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10
- Product
- 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID 129765-95-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25