ChemicalBook > CAS DataBase List > 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID

3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID

Product Name: 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID
CAS No.: 129765-95-3
Chemical Name: 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID
Synonyms: N-Boc-3-amino-3-methylbutanoic Acid;3-(tert-butoxycarbonyl)-3-Methylbutanoic acid;3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID;3-(tert-butoxycarbonylamino)-3-methylbutanoic acid;3-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-methylbutanoic acid;Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-;2-amino-3,3-dimethyl-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
CBNumber: CB1839894
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 129765-95-3.mol

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3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID Property

Boiling point:: 346.5±25.0 °C(Predicted)
Density: 1.082±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.45±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H19NO4/c1-9(2,3)15-8(14)11-10(4,5)6-7(12)13/h6H2,1-5H3,(H,11,14)(H,12,13)
InChIKey: LHJVMOIOTPJSLS-UHFFFAOYSA-N
SMILES: C(O)(=O)CC(NC(OC(C)(C)C)=O)(C)C

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Safety

HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B809790
Product name: 3-((tert-Butoxycarbonyl)amino)-3-methylbutanoicAcid
Packaging: 5g
Price: $340
Updated: 2021/12/16

Iris Biotech GmbH

Product number: BAA2150
Product name: Boc-3-amino-3-methyl-butyricacid
Packaging: 1g
Price: $216
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43557
Product name: 3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid
Packaging: 10g
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB43557
Product name: 3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid
Packaging: 5G
Price: $125
Updated: 2021/12/16

Oakwood

Product number: 092192
Product name: 3-(tert-Butoxycarbonylamino)-3-methylbutanoicacid
Purity: 98%
Packaging: 250mg
Price: $29
Updated: 2021/12/16

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3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic Acid is an intermediate used in the synthesis of (2E)-5-(tert-Butyloxycarbonylamino)-5-methylhex-2-enoic Acid (B809765), which is used in the preparation of C-terminal sulfonamide analogs of NN703 as growth hormone secretagogues.

Synthesis

625-05-8

24424-99-5

129765-95-3

Di-tert-butyl 3-amino-3-methylbutyrate (0.59 g, 5.04 mmol) and di-tert-butyl dicarbonate (1.228 mL, 5.29 mmol) were added to a 1 M potassium hydroxide solution (5.04 mL, 5.04 mmol) as a raw material after dissolving in dioxane (10 mL). The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the dioxane was removed by distillation under reduced pressure. The residue was diluted with water (20 mL) and the pH was adjusted with lithium hydroxide to 13. Subsequently, the mixture was washed three times with ether. Next, the pH was adjusted to 3 with 2N hydrochloric acid to obtain a turbid solution. The solution was extracted four times with ethyl acetate and the combined organic phases were washed with a small amount of brine and dried with anhydrous sodium sulfate. Finally, N-Boc-3-amino-3-methylbutyric acid (860 mg, 3.96 mmol, 79% yield) was obtained as a crystalline solid by vacuum concentration.

References

[1] Patent: US2010/204274, 2010, A1. Location in patent: Page/Page column 30
[2] Patent: US2012/316147, 2012, A1. Location in patent: Page/Page column 43
[3] Patent: WO2012/168350, 2012, A1. Location in patent: Page/Page column 98; 99
[4] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 321
[5] Patent: WO2017/216726, 2017, A1. Location in patent: Page/Page column 650

3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID manufacturers

Career Henan Chemical Co

Product: 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID 129765-95-3
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID 129765-95-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

129765-95-3, 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACIDRelated Search:

5-[(TERT-BUTOXYCARBONYL)AMINO]TETRACYCLO[3.2.0.0(2,7).0(4,6)]HEPTANE-1-CARBOXYLIC ACID (1-TERT-BUTOXYCARBONYLAMINO-CYCLOPENTYL)-ACETIC ACID [4-Amino(tetrahydro-2H-thiopyran-4-yl)]acetic acid, N-BOC protected CIS-2-TERT-BUTOXYCARBONYLAMINO-2-METHYL-CYCLOHEXANECARBOXYLIC ACID (1-TERT-BUTOXYCARBONYLAMINO-CYCLOHEXYL)-ACETIC ACID [4-Amino(tetrahydro-2H-pyran-4-yl)]acetic acid, N-BOC protected 3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID BOC-ALPHA-METHYL-D-ASPARTIC ACID BOC-ALPHA-METHYL-L-ASPARTIC ACID (1R,3R,4S,6S)-4-TERT-BUTOXYCARBONYLAMINO-4,7,7-TRIMETHYL-BICYCLO[4.1.0]HEPTANE-3-CARBOXYLIC ACID CIS-2-TERT-BUTOXYCARBONYLAMINO-2-METHYL-CYCLOPENTANECARBOXYLIC ACID BOC-CIS-1,4-AMINO-1-CYCLOHEXYL ACETIC ACID

3-TERT-BUTOXYCARBONYLAMINO-3-METHYL-BUTYRIC ACID

N-Boc-3-amino-3-methylbutanoic Acid

3-(tert-butoxycarbonylamino)-3-methylbutanoic acid

3-(tert-butoxycarbonyl)-3-Methylbutanoic acid

Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-3-methyl-

3-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-methylbutanoic acid

2-amino-3,3-dimethyl-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid

129765-95-3