7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE

Product Name: 7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE
CAS No.: 158876-66-5
Chemical Name: 7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE
Synonyms: FR 167653;FR 167653 sulfate;7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE
CBNumber: CB1840319
Molecular Formula: C24H20FN5O6S
Formula Weight: 525.51
MOL File: 158876-66-5.mol

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7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0009510
Product name: FR-167653
Purity: 95.00%
Packaging: 5MG
Price: $501.39
Updated: 2021/12/16

AHH

Product number: MT-13568
Product name: 7-(4-Fluorophenyl)-1,2,3,4-tetrahydro-2-(oxophenylacetyl)-8-(4pyridinyl)-pyrazolo[5,1-c][1,2,4]triazinesulfate
Purity: 98%
Packaging: 0.05g
Price: $498
Updated: 2021/12/16

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7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE Chemical Properties,Usage,Production

Uses

FR 167653 (FR 167653 sulfate), an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 (FR 167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo[1][2][3].

in vivo

FR 167653 (FR 167653 sulfate) (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis^[1].

Animal Model:	Inbred male Balbuc mice (aged 8 weeks)^[1]
Dosage:	32 kg/mg
Administration:	Subcutaneous injection; 24-48 hours
Result:	The scores of acute tubular necrosis in FR-167653-treated mice were significantly lower in vehicle-treated mice at 24 and 48 h after ischaemiaureperfusion both in cortex and outer medulla.

References

[1] Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407. DOI:10.1093/ndt/17.3.399
[2] Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67. DOI:10.1097/01.asn.0000037402.83851.5f
[3] Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74. DOI:10.1016/s1053-2498(01)00243-1

7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE Preparation Products And Raw materials

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Preparation Products

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7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE Suppliers

China 7 Germany 1 United Kingdom 2 United States 4 Global 14

3B Pharmachem (Wuhan) International Co.,Ltd.

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Guangzhou Yansai Biological Products Co., Ltd.

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158876-66-5, 7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATERelated Search:

3-(4-Fluorophenyl)-1H-pyrazole 4-(1H-PYRAZOL-4-YL)PYRIDINE 2-(3-METHYL-PYRAZOL-1-YL)-ETHYLAMINE 4-METHYL-5-PHENYL-2H-PYRAZOL-3-YLAMINE 7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE N-ETHYL-2-(1H-PYRAZOL-1-YL)ETHANAMINE CHEMBRDG-BB 4010204 4-(4-Pyridinyl)-1H-pyrazol-3-aMine 4-Methylpyrazolesulfate 3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-amine 5-(4-FLUOROPHENYL)-2H-PYRAZOL-3-YLAMINE 4-Methylpyridine Phenelzine Sulfate

7-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-2-(OXOPHENYLACETYL)-8-(4-PYRIDINYL)-PYRAZOLO[5,1-C][1,2,4]TRIAZINE SULFATE

FR 167653

FR 167653 sulfate

158876-66-5

C24H18FN5O2H2O4S