Glibornuride

ChemicalBook > CAS DataBase List > Glibornuride

Product Name: Glibornuride
CAS No.: 26944-48-9
Chemical Name: Glibornuride
Synonyms: N-((3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide;Glitrim;Ro-6-4563;Glibornurid;Glibornuride;Glibornuride USP/EP/BP;Glibornuride in Methanol;Glibornuride (Mixture of Diastereomers);Glibornuride Solution in Acetonitrile/Water, 1000μg/mL;1-[p-Tolylsulfonyl]-3-[2-endo-hydroxy-3-endo-D-bornyl] urea
CBNumber: CB1875191
Molecular Formula: C18H26N2O4S
Formula Weight: 366.47504
MOL File: 26944-48-9.mol

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Glibornuride Property

Melting point:: 192-195° (ethanol-water); also reported as 195-198°
alpha: D +63.8° (ethanol)
Density: 1.1793 (rough estimate)
refractive index: 1.6930 (estimate)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (682.17 mM; Need ultrasonic)
form: Solid
pka: 5.20±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: G409700
Product name: Glibornuride
Packaging: 10mg
Price: $240
Updated: 2021/12/16

Usbiological

Product number: 164299
Product name: Glibornuride
Packaging: 2.5mg
Price: $355
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010408
Product name: GLIBORNURIDE
Purity: 95.00%
Packaging: 1MG
Price: $750.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010408
Product name: GLIBORNURIDE
Purity: 95.00%
Packaging: 5MG
Price: $1963.5
Updated: 2021/12/16

AvaChem

Product number: 3155
Product name: Glibornuride
Packaging: 25mg
Price: $390
Updated: 2021/12/16

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Glibornuride Chemical Properties,Usage,Production

Originator

Glutril,Roche,W. Germany,1972

Uses

Glibornuride has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. Glibornuride is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus.

Definition

ChEBI: Glibornuride is a monoterpenoid.

Manufacturing Process

2.1 grams of 3-endo-aminoborneol hydrochloride and 2.4 grams of O-methylN-p-toluene-sulfonyl-urea are heated at 125°C for 3 hours with 2 ml of dimethylformamide. After cooling, the reaction mixture is stirred with 100 ml of water for 10 minutes, while a pH of 3.5 is maintained by the addition of a few drops of dilute hydrochloric acid. The precipitate is removed by filtration, washed with water and suspended in 100 ml of water. The suspension is dissolved by the addition of 20 ml of 1 N caustic soda. The alkaline solution is extracted with ether, acidified with dilute hydrochloric acid and filtered. The precipitate is washed with water and recrystallized from alcohol/water to yield 1-(p-toluene-sulfonyl)-3-(2-endo-hydroxy-3-endo-bornyl)-urea having a melting point of 193° to 195°C.

brand name

Glutril (Hoffmann-LaRoche).

Therapeutic Function

Oral hypoglycemic

Glibornuride Preparation Products And Raw materials

Raw materials

Preparation Products

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26944-48-9, GlibornurideRelated Search:

Silibinin Viaminate Nitrofurazone Miglitol Acarbose Gliclazide Voglibose Repaglinide Pioglitazone hydrochloride Nateglinide Gliquidone Glimepiride Glibornuride L-MENTHYLAMINE glycyclamide DL-Isoborneol CIS-2-METHYLAMINO-CYCLOHEXANOL Tolpentamide

1-[p-Tolylsulfonyl]-3-[2-endo-hydroxy-3-endo-D-bornyl] urea

N-((3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide

Glibornuride (Mixture of Diastereomers)

Glibornuride

Glitrim

N-[[[(1S,2S,3R,4R)-2-Hydroxyborn-3-yl]amino]carbonyl]-4-methylbenzenesulfonamide

Ro-6-4563

1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(4-methylphenyl)sulfonyl-urea

1-(6-hydroxy-1,7,7-trimethyl-5-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea

1-(6-hydroxy-1,7,7-trimethyl-5-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonyl-urea

1-(3-hydroxy-4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea

Glibornurid

Benzenesulfonamide, N-[[[(1S,2S,3R,4R)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]amino]carbonyl]-4-methyl-

Glibornuride Solution in Acetonitrile/Water, 1000μg/mL

Glibornuride USP/EP/BP

Inhibitor,K channel,KcsA,blocker ATP,sensitive,Glibornuride,inhibit,Parsley,Streptozotocin,Antidiabetic,Potassium Channel

N-(((1S,2S,3R,4S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide

3-[(1S,2S,3R,4R)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl]-1-(4-methylbenzenesulfonyl)urea

Glibornuride in Methanol

26944-48-9

C18H26N2O4S

Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds