ChemicalBook > CAS DataBase List > Glibornuride

Glibornuride

Product Name
Glibornuride
CAS No.
26944-48-9
Chemical Name
Glibornuride
Synonyms
N-((3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide;Glitrim;Ro-6-4563;Glibornurid;Glibornuride;Glibornuride USP/EP/BP;Glibornuride (Mixture of Diastereomers);Glibornuride Solution in Acetonitrile/Water, 1000μg/mL;1-[p-Tolylsulfonyl]-3-[2-endo-hydroxy-3-endo-D-bornyl] urea;1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(4-methylphenyl)sulfonyl-urea
CBNumber
CB1875191
Molecular Formula
C18H26N2O4S
Formula Weight
366.47504
MOL File
26944-48-9.mol
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Glibornuride Property

Melting point:
192-195° (ethanol-water); also reported as 195-198°
alpha 
D +63.8° (ethanol)
Density 
1.1793 (rough estimate)
refractive index 
1.6930 (estimate)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (682.17 mM; Need ultrasonic)
pka
5.20±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
G409700
Product name
Glibornuride
Packaging
10mg
Price
$240
Updated
2021/12/16
Usbiological
Product number
164299
Product name
Glibornuride
Packaging
2.5mg
Price
$355
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010408
Product name
GLIBORNURIDE
Purity
95.00%
Packaging
1MG
Price
$750.75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010408
Product name
GLIBORNURIDE
Purity
95.00%
Packaging
5MG
Price
$1963.5
Updated
2021/12/16
AvaChem
Product number
3155
Product name
Glibornuride
Packaging
25mg
Price
$390
Updated
2021/12/16
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Glibornuride Chemical Properties,Usage,Production

Originator

Glutril,Roche,W. Germany,1972

Uses

Glibornuride has been shown to antagonize the relaxant response to the K+ channel opener cromakalim and produce airway smooth muscle relaxation. Glibornuride is associated with lactic acidosis and hypoglycemia in patients with type 2 diabetes melitus.

Definition

ChEBI: Glibornuride is a monoterpenoid.

Manufacturing Process

2.1 grams of 3-endo-aminoborneol hydrochloride and 2.4 grams of O-methylN-p-toluene-sulfonyl-urea are heated at 125°C for 3 hours with 2 ml of dimethylformamide. After cooling, the reaction mixture is stirred with 100 ml of water for 10 minutes, while a pH of 3.5 is maintained by the addition of a few drops of dilute hydrochloric acid. The precipitate is removed by filtration, washed with water and suspended in 100 ml of water. The suspension is dissolved by the addition of 20 ml of 1 N caustic soda. The alkaline solution is extracted with ether, acidified with dilute hydrochloric acid and filtered. The precipitate is washed with water and recrystallized from alcohol/water to yield 1-(p-toluene-sulfonyl)-3-(2-endo-hydroxy-3-endo-bornyl)-urea having a melting point of 193° to 195°C.

brand name

Glutril (Hoffmann-LaRoche).

Therapeutic Function

Oral hypoglycemic

Glibornuride Preparation Products And Raw materials

Raw materials

Preparation Products

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26944-48-9, GlibornurideRelated Search:


  • 1-[p-Tolylsulfonyl]-3-[2-endo-hydroxy-3-endo-D-bornyl] urea
  • N-((3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide
  • Glibornuride (Mixture of Diastereomers)
  • Glibornuride
  • Glitrim
  • N-[[[(1S,2S,3R,4R)-2-Hydroxyborn-3-yl]amino]carbonyl]-4-methylbenzenesulfonamide
  • Ro-6-4563
  • 1-(3-hydroxy-4,7,7-trimethyl-norbornan-2-yl)-3-(4-methylphenyl)sulfonyl-urea
  • 1-(6-hydroxy-1,7,7-trimethyl-5-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea
  • 1-(6-hydroxy-1,7,7-trimethyl-5-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonyl-urea
  • 1-(3-hydroxy-4,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)-3-(4-methylphenyl)sulfonylurea
  • Glibornurid
  • Benzenesulfonamide, N-[[[(1S,2S,3R,4R)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl]amino]carbonyl]-4-methyl-
  • Glibornuride Solution in Acetonitrile/Water, 1000μg/mL
  • Glibornuride USP/EP/BP
  • Inhibitor,K channel,KcsA,blocker ATP,sensitive,Glibornuride,inhibit,Parsley,Streptozotocin,Antidiabetic,Potassium Channel
  • N-(((1S,2S,3R,4S)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)carbamoyl)-4-methylbenzenesulfonamide
  • 26944-48-9
  • C18H26N2O4S
  • Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds