oxeladin

Product Name
oxeladin
CAS No.
468-61-1
Chemical Name
oxeladin
Synonyms
oxeladin;oxeladin USP/EP/BP;IQADUMSPOQKAAO-UHFFFAOYSA-N;2-(β-1Diethylaminoethoxy)ethyl diethylphenyl acetate;2-(2-diethylaminoethoxy)ethyl 2-ethyl-2-phenylbutyrate;2-[2-(Diethylamino)ethoxy]ethyl 2-ethyl-2-phenylbutanoate;α,α-Diethylbenzeneacetic acid 2-(2-diethylaminoethoxy)ethyl ester;2-Ethyl-2-phenylbutyric acid 2-[2-(diethylamino)ethoxy]ethyl ester;Benzeneacetic acid, α,α-diethyl-, 2-[2-(diethylamino)ethoxy]ethyl ester
CBNumber
CB1875328
Molecular Formula
C20H33NO3
Formula Weight
335.48
MOL File
468-61-1.mol
More
Less

oxeladin Property

Melting point:
25°C
Boiling point:
bp0.5 150°; bp0.1 140°
Density 
1.0720 (rough estimate)
refractive index 
1.5614 (estimate)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

oxeladin Chemical Properties,Usage,Production

Originator

Silopentol,Schulte,W. Germany ,1970

Manufacturing Process

Preparation of Diethylphenylacetonitrile: 25 grams of sodium was dissolved in 300 ml liquid ammonia containing 0.3 gram ferric chloride and 59 grams phenylacetonitrile was added slowly with stirring. After about 15 minutes a cooled solution of 80 grams of ethyl chloride in 200 ml dry ether was added and the mixture stirred for 1 hour. The ammonia was then allowed to evaporate, water added and the ether layer separated, dried, concentrated and the residual oil distilled in vacuo to yield diethylphenylacetonitrile as an oil, BP 85°C/1 mm.
Preparation of Diethylphenylacetic Acid: 46 grams of the foregoing nitrile was added to 140 ml ethylene glycol containing 36 grams potassium hydroxide and the mixture refluxed with stirring for about 20 hours. The mixture was diluted with water, extracted with light petroleum (BP 60° to 80°C) to remove traces of impurities and then acidified to yield diethylphenylacetic acid which was recrystallized from dilute ethanol (40% v/v ethanol in water).
Preparation of 2-(β-Chloroethoxy)Ethyl Diethylphenylacetate: 19.2 grams of the foregoing acid was added to a solution of 4 grams of sodium hydroxide in 40 ml ethylene glycol. 28.6 grams β,β'-dichlorodiethyl ether was added and the mixture refluxed for 1 hour. After removal of solvent under reduced pressure, 150 ml water was added to the residue and the product extracted with ether. The ethereal solution was dried, concentrated and the residue distilled in vacuo to yield the product as an oil, BP 140°C/0.7 mm.
Preparation of 2-(β-Diethylaminoethoxy)Ethyl Diethylphenylacetate: A mixture of 21 grams of 2-(β-chloroethoxy)ethyl diethylphenylacetate and 14 grams diethylamine was heated under pressure in a sealed tube at 140°C for 5 hours. After cooling, the mixture was dissolved in dilute hydrochloric acid and extracted with ether to remove traces of neutral impurities. The acid layer was then made alkaline with 10% w/v sodium hydroxide solution with cooling, and re-extracted with two portions of ether. The ether extract was dried, the ether distilled off and the residue distilled in vacuo to yield the product as an oil, BP 140°C/0.1 mm.

Therapeutic Function

Antitussive

oxeladin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

oxeladin Suppliers

Dideu Industries Group Limited
Tel
029-88380327; 17691182729
Email
Service@dideu.com
Country
CHINA
ProdList
30013
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
86-18871470254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28229
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Fax
+86-29-88380327
Email
1012@dideu.com
Country
CHINA
ProdList
3949
Advantage
58
Wuhan pengyin Pharmaceutical Co., Ltd
Tel
Email
1939328613@qq.com
Country
China
ProdList
397
Advantage
58
More
Less

View Lastest Price from oxeladin manufacturers

Dideu Industries Group Limited
Product
oxeladin USP/EP/BP 468-61-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100Tons min
Release date
2021-06-10
Shaanxi Dideu Medichem Co. Ltd
Product
Oxeladin 468-61-1
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 tons
Release date
2020-04-24

468-61-1, oxeladinRelated Search:


  • 2-(2-diethylaminoethoxy)ethyl 2-ethyl-2-phenylbutyrate
  • oxeladin
  • 2-(β-1Diethylaminoethoxy)ethyl diethylphenyl acetate
  • 2-Ethyl-2-phenylbutyric acid 2-[2-(diethylamino)ethoxy]ethyl ester
  • α,α-Diethylbenzeneacetic acid 2-(2-diethylaminoethoxy)ethyl ester
  • IQADUMSPOQKAAO-UHFFFAOYSA-N
  • 2-[2-(Diethylamino)ethoxy]ethyl 2-ethyl-2-phenylbutanoate
  • Benzeneacetic acid, α,α-diethyl-, 2-[2-(diethylamino)ethoxy]ethyl ester
  • oxeladin USP/EP/BP
  • 468-61-1
  • 468-68-1