fenclofenac
- Product Name
- fenclofenac
- CAS No.
- 34645-84-6
- Chemical Name
- fenclofenac
- Synonyms
- Flenac;R 67408;RX 67408;fenclofenac;[o-(2,4-Dichlorophenoxy)phenyl]acetic acid;Benzeneacetic acid, 2-(2,4-dichlorophenoxy)-;2-[2-(2,4-dichlorophenoxy)phenyl]acetic acid
- CBNumber
- CB1885619
- Molecular Formula
- C14H10Cl2O3
- Formula Weight
- 297.136
- MOL File
- 34645-84-6.mol
fenclofenac Property
- Melting point:
- 135.0℃
- Boiling point:
- 410.72°C (rough estimate)
- Density
- 1.3076 (rough estimate)
- refractive index
- 1.5209 (estimate)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- pKa 4.53 (Uncertain)
- color
- Off-White to Light Brown
- Water Solubility
- 8.439mg/L(25 ºC)
- Stability:
- Hygroscopic
Safety
- Toxicity
- LD50 oral in rat: 2280mg/kg
N-Bromosuccinimide Price
- Product number
- F247505
- Product name
- Fenclofenac
- Packaging
- 250mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- API0015862
- Product name
- 2-(2-(2,4-DICHLOROPHENOXY)PHENYL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.86
- Updated
- 2021/12/16
- Product number
- 18627
- Product name
- Fenclofenac
- Packaging
- 25mg
- Price
- $1500
- Updated
- 2021/12/16
- Product number
- SC-86969
- Product name
- FENCLOFENAC
- Purity
- 95
- Packaging
- 5g
- Price
- $1666
- Updated
- 2021/12/16
fenclofenac Chemical Properties,Usage,Production
Originator
Flenac,Reckitt and Colman
Uses
Anti-inflammatory.
Uses
Fenclofenac is used for the same indications as diclofenac.
Uses
Fenclofenac is a non-steroidal anti-inflammatory agent functioning as a protein-pump inhibitor.
Definition
ChEBI: Fenclofenac is an aromatic ether.
Manufacturing Process
1-[2-(2,5-Dichloro-phenoxy)-phenyl]-ethanone was prepared from a mixture of 2,4-dichlorphenol, 2-chloroacetophenone and copper catalyst (prepared according to R.Q. Brewster and T. Groening Organic Syntheses, John Wiley and Sons, Inc., New York, 1943, Coll. Vol.11, p.446). 1 mol of the above phenoxy compound was mixed with 3 mol of sulfur and 3.5 mol of morpholine and heated under gentle reflux for 72 hours. The mixture was evaporated, water was added and extracted with ether. The aueous layer was then acidified with concentrated hydrochloric acid and the product was extracted into ether, the ether extract was dried and evaporated. The solid residue was recrystallized from CCl4 to give [2-(2,4-dichlorophenoxy)-phenyl]acetic acid, Yield 37%; MP: 134°-136°C.
brand name
Feclan;Gidalon;Monosan;Rx 67408nac.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Fenclofenac, a nonsteroidal anti-inflammatory agent, was introduced in 1978 for the treatment of rheumatic disorders. By 1984 its use in the United Kingdom was associated with serious adverse effects, predominantly skin rashes, some of which were fatal. This led to the UK Committee on Safety of Medicine's refusal to renew the product licence and to the subsequent withdrawal of the drug by the manufacturer in all countries in which it was marketed.
Synthesis
Fenclofenac, o-[2,4-dichlorophenoxy)phenyl]acetic acid (3.2.45), is synthesized from 2,4-dichlorophenol and 2-chloroacetophenone, the reaction of which in the presence of sodium hydroxide and powdered copper forms the corresponding 2-acetyl-2??,4??-dichloro-diphenyl ester (3.2.43). The resulting product is reacted with sulfur and morpholine according to Willgerodt method, giving thioamide (3.2.44), which is further hydrolyzed to the desired fenclofenac [109,110].
fenclofenac Preparation Products And Raw materials
Raw materials
Preparation Products
fenclofenac Suppliers
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 9387
- Advantage
- 52
- Tel
- 18136598690 18136597130
- Fax
- 86-0519-89617886
- Country
- China
- ProdList
- 235
- Advantage
- 58
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9346
- Advantage
- 58
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 13382066392
- Country
- CHINA
- ProdList
- 4877
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- info@synzest.com
- Country
- China
- ProdList
- 9286
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 15583
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@lanospharma.com
- Country
- China
- ProdList
- 6329
- Advantage
- 56