16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
- Product Name
- 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
- CAS No.
- 77017-20-0
- Chemical Name
- 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
- Synonyms
- BNKY015-BD01;Desonide Impurity M1;Budesonide Impurity 33;Budesonide Impurity 12;Pregna-1,4,9(11)-triene-16,17-diol-3,20-dione 21-acetate;Pregna-1,4,9(11)-triene-16α,17α-diol-3,20-dione 21-acetate;16,17-Dihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate;21-(Acetyloxy)-16α,17-dihydroxypregna-1,4,9(11)-triene-3,20-dione;16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate;(16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
- CBNumber
- CB1894903
- Molecular Formula
- C23H28O6
- Formula Weight
- 400.46482
- MOL File
- 77017-20-0.mol
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Property
- Melting point:
- 213-215 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
- Boiling point:
- 576.7±50.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- solubility
- soluble in Acetone, Dichloromethane
- pka
- 11.92±0.70(Predicted)
- Water Solubility
- 38.72mg/L at 25℃
- LogP
- 2.26 at 25℃
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 67632
- Product name
- (16α)-21-Acetyloxy-16,17-dihydroxy-pregna-1,4,9(11)-triene-3,20-dione
- Packaging
- 10mg
- Price
- $640
- Updated
- 2021/12/16
- Product number
- CHM0006413
- Product name
- 16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- CHM0006413
- Product name
- 16,17,21-TRIHYDROXYPREGNA-1,4,9(11),TRIENE-3,20-DIONE-21-ACETATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1871.1
- Updated
- 2021/12/16
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Chemical Properties,Usage,Production
Uses
Intermediate in the preparation of antiinflammatory compounds.
Synthesis
2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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