tolycaine Property

Melting point:

<25 °C

Boiling point:

bp5 190-192°

Density 

1.113±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 100 mg/mL (359.26 mM)

pka

13.61±0.70(Predicted)

Hazard and Precautionary Statements (GHS)

tolycaine Chemical Properties,Usage,Production

Originator

Tolycaine Hydrochloride,ZYF Pharm Chemical

Definition

ChEBI: Tolycaine is an amidobenzoic acid.

Manufacturing Process

A suspension of 40 g 2-amino-3-methylbenzoic acid methyl ester in 125 ml of benzene was added 125 ml of saturated solution of sodium acetate and then at 0-5°C was added 37 g chloracetylchloride. The mixture was stirred for 1 hour at room temperature. The mixture was filtered. The organic layer was with 10% solution of potassium carbonate and dries under calcium chloride. By distillation of the mixture was obtained 15 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester; melting point 86-87.5°C (crystallization from a mixture acetic acid and ligroin); yield 21.8 g.
A mixture of 16 g of 2-(2-chloroacetylamino)-3-methylbenzoic acid methyl ester and 10 g diethyl amine in benzene was refluxed for 5 hours. After cooling the diethyl amine hydrochloride was deleted by filtration. The organic layer was washed with 2 N hydrochloric acid. To the solution was added potassium carbonate. The product was extracted with ether and distilled.

brand name

Tolycaine Hydrochloride is JAN.

Therapeutic Function

Local anesthetic