5-chloro-1-methyl-1H-indole-2,3-dione

Product Name: 5-chloro-1-methyl-1H-indole-2,3-dione
CAS No.: 60434-13-1
Chemical Name: 5-chloro-1-methyl-1H-indole-2,3-dione
Synonyms: Einecs 262-231-5;5-Chloro-1-methylisatin;5-Chloro-1-methylindole-2,3-dione;5-Chloro-1-methyl-2,3-indolinedione;5-Chloro-1-methylindoline-2,3-dione;1-Methyl-5-chloroindoline-2,3-dione;5-chloro-1-methyl-1H-indole-2,3-dione;1H-Indole-2,3-dione, 5-chloro-1-methyl-;5-chloro-1-methyl-1H-indole-2,3-dione(SALTDATA: FREE)
CBNumber: CB1931190
Molecular Formula: C9H6ClNO2
Formula Weight: 195.6
MOL File: 60434-13-1.mol

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5-chloro-1-methyl-1H-indole-2,3-dione Property

Melting point:: 175.0 to 179.0 °C
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: Orange to Red
λmax: 426nm(EtOH)(lit.)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3195
Product name: 5-Chloro-1-methylisatin
Purity: >98.0%(GC)
Packaging: 200mg
Price: $129
Updated: 2025/07/31

TCI Chemical

Product number: C3195
Product name: 5-Chloro-1-methylisatin
Purity: >98.0%(GC)
Packaging: 1g
Price: $386
Updated: 2025/07/31

TRC

Product number: C602150
Product name: 5-Chloro-1-methylindoline-2,3-dione
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143306
Product name: 5-Chloro-1-methylindoline-2,3-dione
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC143306
Product name: 5-Chloro-1-methylindoline-2,3-dione
Packaging: 250mg
Price: $55
Updated: 2021/12/16

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5-chloro-1-methyl-1H-indole-2,3-dione Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 39, p. 5072, 1996 DOI: 10.1021/jm960603e

Synthesis

872305-97-0

60434-13-1

GENERAL METHODS: A mixture of N-methyl-2-oxo-N-phenylacetamide (0.4 mmol) and ferric chloride (10 mol%) was dissolved in 2 mL of dimethylsulfoxide (DMSO), and the reaction was stirred for 1.5 h at 100 °C under air atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate. The organic layers were combined, washed with saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. Purification of the crude product by rapid column chromatography on silica gel (petroleum ether/ethyl acetate = 10:1) afforded 1-methyldihydroindole-2,3-dione as a red solid (60 mg, 93% yield).

References

[1] RSC Advances, 2015, vol. 5, # 125, p. 103280 - 103283
[2] Tetrahedron Letters, 2016, vol. 57, # 1, p. 39 - 42
[3] Synlett, 2016, vol. 27, # 8, p. 1292 - 1296
[4] Journal of the American Chemical Society, 2010, vol. 132, # 26, p. 8900 - 8902
[5] Chemistry - A European Journal, 2007, vol. 13, # 4, p. 1032 - 1046

5-chloro-1-methyl-1H-indole-2,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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5-chloro-1-methyl-1H-indole-2,3-dione Suppliers

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60434-13-1, 5-chloro-1-methyl-1H-indole-2,3-dioneRelated Search:

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5-Chloro-1-methylisatin

5-chloro-1-methyl-1H-indole-2,3-dione

1-Methyl-5-chloroindoline-2,3-dione

5-Chloro-1-methylindoline-2,3-dione

Einecs 262-231-5

5-chloro-1-methyl-1H-indole-2,3-dione(SALTDATA: FREE)

1H-Indole-2,3-dione, 5-chloro-1-methyl-

5-Chloro-1-methyl-2,3-indolinedione

5-Chloro-1-methylindole-2,3-dione

60434-13-1