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cefacetrile

Product Name
cefacetrile
CAS No.
10206-21-0
Chemical Name
cefacetrile
Synonyms
cefacetrile;Cefacetrilo;Cefacetrilum;CEPHACETRILE;Cefepime API;cefacetrile USP/EP/BP;Cefcapene Pivoxil API;Cefacetrilum [inn-latin];Cephacetrile,Cefacetrile;Cefacetrilo [inn-spanish]
CBNumber
CB1934757
Molecular Formula
C13H13N3O6S
Formula Weight
339.32
MOL File
10206-21-0.mol
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cefacetrile Property

Melting point:
133-135°C
Boiling point:
757.5±60.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
pKa 1.97 (Uncertain)
form 
Solid
color 
White to Pale Beige
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C231500
Product name
Cefacetrile
Packaging
5mg
Price
$95
Updated
2021/12/16
TRC
Product number
C231500
Product name
Cefacetrile
Packaging
25mg
Price
$235
Updated
2021/12/16
Usbiological
Product number
257230
Product name
Cefacetrile
Packaging
5mg
Price
$425
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009120
Product name
CEFACETRILE
Purity
95.00%
Packaging
25MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009120
Product name
CEFACETRILE
Purity
95.00%
Packaging
250MG
Price
$1871.1
Updated
2021/12/16
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cefacetrile Chemical Properties,Usage,Production

Description

This drug is similar to cephalothin, but after intravenous administration, higher peak serum levels are attained, and its serum half-life is longer (Brogard et al., 1973a; Brogard et al., 1973b). However, cephacetrile appears to have no clinical advantages over cephalothin, as demonstrated in one comparative trial (Jackson et al., 1974). It has most recently been available in Italy.

Chemical Properties

Pale Beige Solid

Originator

Celospor,Ciba Geigy,Switz.,1969

Uses

A cephalosporin antibiotic. Antibacterial.

Definition

ChEBI: Cefacetrile is a cephalosporin.

Manufacturing Process

13.6 g (0.05 mol) of 7-aminocephalosporanic acid are taken up in a mixture of 150 ml of methylene chloride and 19.5 ml of tributylamine (0.12 mol) and at 0°C a solution of 8.4 g of cyanoacetylchloride (0.07 mol) in 100 ml of methylene chloride is stirred in. The bath is then stirred for ? hour at 0°C and for ? hour at 20°C, the reaction solution is evaporated under vacuum and the residue taken up in 10% aqueous dipotassium hydrogenphosphate solution. This aqueous phase is washed with ethyl acetate, acidified to pH 2.0 with concentrated hydrochloric acid and extracted with ethyl acetate.
After having been dried over sodium sulfate and evaporated under vacuum, this extract gives as a solid residue 14.7 g of crude 7-cyanoacetylamino-cephalosporanic acid which is purified by chromatography on 30 times its own weight of silica gel. The fractions eluted with chloroform plus acetone (7:3) furnish a product which crystallizes from acetone plus ether in the form of needles melting at 168° to 170°C with decomposition.
5.10 g (15 mmol) of 7-cyanoacetyl-aminocephalosporanic acid are suspended in 102 ml of distilled water and converted into the sodium salt by stirring in dropwise 15 ml of N sodium hydroxide solution.

Therapeutic Function

Antibiotic

Antimicrobial activity

Its spectrum resembles that of cefalotin. Following an intramuscular dose of 1 g, a peak plasma concentration around 15 mg/L is achieved at 1 h. About 25% is bound to plasma protein. Penetration into the CSF is limited. About 80% of the drug is excreted in the urine, producing concentrations in excess of 1 g/L, 25% of which is in the desacetylated form. Clearance is depressed by probenecid and in renal failure. Little is excreted in the bile. Manifestations of hypersensitivity in patients not known to be allergic to β-lactam antibiotics are common. It is no longer used.

cefacetrile Preparation Products And Raw materials

Raw materials

Preparation Products

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cefacetrile Suppliers

Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from cefacetrile manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
cefacetrile 10206-21-0
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-25
Career Henan Chemical Co
Product
cefacetrile 10206-21-0
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

10206-21-0, cefacetrile Related Search:


  • Cephacetrile (base and/or unspecified salts)
  • (6R,7R)-7-(2-Cyanoacetylamino)-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]octan-2-ene-2-carboxylic acid
  • (7R)-3-[(Acetyloxy)methyl]-7-[(cyanoacetyl)amino]cepham-3-ene-4-carboxylic acid
  • (6R,7R)-3-Acetoxymethyl-7-(2-cyanacetamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure
  • 7-(2-Cyanacetamido)-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carboxylat acetat (ester)
  • 7-Cyanacetylamino-cephalosporansaeure
  • Cefacetrilo
  • Cefacetrilo [inn-spanish]
  • Cefacetrilum
  • Cefacetrilum [inn-latin]
  • cefacetrile
  • CEPHACETRILE
  • (6R,7R)-3-[(Acetyloxy)Methyl]-7-[(2-cyanoacetyl)aMino]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid
  • 7-(2-CyanoacetaMido)-3-(hydroxyMethyl)-8-oxo-5-thia- -1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Acetate (Ester)
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[(2-cyanoacetyl)amino]-8-oxo-, (6R,7R)-
  • cefacetrile USP/EP/BP
  • Cephacetrile,Cefacetrile
  • Cefcapene Pivoxil API
  • Cefepime API
  • (6R,7R)-3-(Acetoxymethyl)-7-(2-cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cephacetrile 100 μg/ml Acetonitrile
  • 10206-21-0
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds