ChemicalBook > CAS DataBase List > lonazolac

lonazolac

Product Name
lonazolac
CAS No.
53808-88-1
Chemical Name
lonazolac
Synonyms
lonazolac;LONAZOLAC CALCIUM;3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid;1H-Pyrazole-4-acetic acid, 3-(4-chlorophenyl)-1-phenyl-;2-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid;anti-inflammatory,antirheumatic,non-acidic,Inhibitor,inhibit,Lonazolac
CBNumber
CB1936094
Molecular Formula
C17H13ClN2O2
Formula Weight
312.755
MOL File
53808-88-1.mol
More
Less

lonazolac Property

Melting point:
150-151°
pka
4.3(at 25℃)
More
Less

Safety

Toxicity
LD50 in male mice, rats (mg/kg): 195, 165 i.v. (Riedel)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0015859
Product name
[3-(4-CHLOROPHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]ACETIC ACID
Purity
95.00%
Packaging
1G
Price
$453.6
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0015859
Product name
[3-(4-CHLOROPHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]ACETIC ACID
Purity
95.00%
Packaging
2.5G
Price
$1227.82
Updated
2021/12/16
More
Less

lonazolac Chemical Properties,Usage,Production

Originator

Irriten,Tosse,W. Germany,1981

Definition

ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-(4-chlorophenyl)-1-phenylpyrazol-4-yl group.

Manufacturing Process

17.6 g 1-phenyl-3-(p-chlorophenyl)-pyrazol-4-acetonitrile and 180 ml 25% aqueous hydrochloric acid were mixed and heated to the boiling temperature under reflux for 6 hours. To the mixture was then added dropwise concentrated aqueous sodium hydroxide until the pH of the mixture reached a value in the range from 3 to 5. The free pyrazol-4-acetic acid precipitated thereby was filtered off, redissolved in dilute aqueous sodium hydroxide, the solution cleared by treatment with activated carbon, and the pyrazol-4-acetic acid precipitated by acidifying the solution by the addition of dilute mineral acid, sulfuric acid. The filtered acid was crystallized from a mixture of ethanol and water. 17.1 g 1-phenyl-3-(p-chlorophenyl)pyrazol-4-acetic acid, melting at 148°C to 150°C, were obtained, representing a yield of 91%.

Therapeutic Function

Antiinflammatory

lonazolac Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

lonazolac Suppliers

Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31557
Advantage
55
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24017
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 15162312715
Email
sales@szzxbio.com
Country
China
ProdList
2992
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4299
Advantage
58
Yantai Lianhua Technology Co., Ltd
Tel
15552437730
Email
1701654643@qq.com
Country
China
ProdList
11308
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12007
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58

53808-88-1, lonazolacRelated Search:


  • 2-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid
  • lonazolac
  • LONAZOLAC CALCIUM
  • 3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid
  • 1H-Pyrazole-4-acetic acid, 3-(4-chlorophenyl)-1-phenyl-
  • anti-inflammatory,antirheumatic,non-acidic,Inhibitor,inhibit,Lonazolac
  • 53808-88-1
  • 2C17H12ClN2O2Ca