lonazolac
- Product Name
- lonazolac
- CAS No.
- 53808-88-1
- Chemical Name
- lonazolac
- Synonyms
- lonazolac;LONAZOLAC CALCIUM;3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid;1H-Pyrazole-4-acetic acid, 3-(4-chlorophenyl)-1-phenyl-;2-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]acetic acid;anti-inflammatory,antirheumatic,non-acidic,Inhibitor,inhibit,Lonazolac
- CBNumber
- CB1936094
- Molecular Formula
- C17H13ClN2O2
- Formula Weight
- 312.755
- MOL File
- 53808-88-1.mol
lonazolac Property
- Melting point:
- 150-151°
- pka
- 4.3(at 25℃)
Safety
- Toxicity
- LD50 in male mice, rats (mg/kg): 195, 165 i.v. (Riedel)
N-Bromosuccinimide Price
- Product number
- API0015859
- Product name
- [3-(4-CHLOROPHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]ACETIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $453.6
- Updated
- 2021/12/16
- Product number
- API0015859
- Product name
- [3-(4-CHLOROPHENYL)-1-PHENYL-1H-PYRAZOL-4-YL]ACETIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1227.82
- Updated
- 2021/12/16
lonazolac Chemical Properties,Usage,Production
Originator
Irriten,Tosse,W. Germany,1981
Definition
ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 3-(4-chlorophenyl)-1-phenylpyrazol-4-yl group.
Manufacturing Process
17.6 g 1-phenyl-3-(p-chlorophenyl)-pyrazol-4-acetonitrile and 180 ml 25% aqueous hydrochloric acid were mixed and heated to the boiling temperature under reflux for 6 hours. To the mixture was then added dropwise concentrated aqueous sodium hydroxide until the pH of the mixture reached a value in the range from 3 to 5. The free pyrazol-4-acetic acid precipitated thereby was filtered off, redissolved in dilute aqueous sodium hydroxide, the solution cleared by treatment with activated carbon, and the pyrazol-4-acetic acid precipitated by acidifying the solution by the addition of dilute mineral acid, sulfuric acid. The filtered acid was crystallized from a mixture of ethanol and water. 17.1 g 1-phenyl-3-(p-chlorophenyl)pyrazol-4-acetic acid, melting at 148°C to 150°C, were obtained, representing a yield of 91%.
Therapeutic Function
Antiinflammatory
lonazolac Preparation Products And Raw materials
Raw materials
Preparation Products
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