6-Iodo-1-tetralone
- Product Name
- 6-Iodo-1-tetralone
- CAS No.
- 340825-13-0
- Chemical Name
- 6-Iodo-1-tetralone
- Synonyms
- 6-Iodo-α-Tetralone;6-Iodo-1-tetralone;6-iodotetralin-1-one;6-Iodo-3,4-dihydronaphthalen-1(2H);6-Iodo-3,4-dihydro-2H-phthalen-1-one;6-Iodo-3,4-dihydro-2H-naphthalen-1-one;1(2H)-Naphthalenone, 3,4-dihydro-6-iodo-;6-iodo-1,2,3,4-tetrahydronaphthalen-1-one
- CBNumber
- CB1947892
- Molecular Formula
- C10H9IO
- Formula Weight
- 272.08
- MOL File
- 340825-13-0.mol
6-Iodo-1-tetralone Property
- Boiling point:
- 344.3±31.0 °C(Predicted)
- Density
- 1.757±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C10H9IO/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h4-6H,1-3H2
- InChIKey
- TUMAMZXVZVEYLU-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(I)C=C2)CCC1
Safety
- HS Code
- 2914390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 3557AJ
- Product name
- 6-Iodo-3,4-dihydronaphthalen-1(2H)-one
- Packaging
- 25mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- HCH0036944
- Product name
- 6-IODO-1-TETRALONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1067.22
- Updated
- 2021/12/16
- Product number
- 3557AJ
- Product name
- 6-Iodo-3,4-dihydronaphthalen-1(2H)-one
- Packaging
- 10g
- Price
- $1104
- Updated
- 2021/12/16
- Product number
- 10R0312
- Product name
- 6-Iodo-3,4-dihydro-2H-naphthalen-1-one
- Purity
- 97%
- Packaging
- 5g
- Price
- $1998
- Updated
- 2021/12/16
- Product number
- CD12081544
- Product name
- 6-Iodo-3,4-dihydronaphthalen-1(2H)-one
- Purity
- 98%
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
6-Iodo-1-tetralone Chemical Properties,Usage,Production
Synthesis
3470-53-9
340825-13-0
The general procedure for the synthesis of 6-iodo-3,4-dihydronaphthalen-1(2H)-one from 6-amino-1,2,3,4-tetrahydro-1-naphthalenone is as follows:[Synthesis Example 1 - Synthesis of Intermediates for Specific Compounds 1] Compound (2) was synthesized according to the formula of the reaction (Scheme).6-Amino-1,2,3,4-tetrahydro-1-naphthalenone (20 g, 119.0 mmol) Purchased from SIGMA Aldrich Co. and untreated before use. 6-Amino-1,2,3,4-tetrahydro-1-naphthalenone and 15% HCl (96 mL) were added to a 500 mL beaker. The aqueous sodium nitrite solution (9.9 g, 143.0 mmol dissolved in 42 mL of water) was added slowly and dropwise under the cooling of an ice bath, keeping the temperature of the reaction mixture below 5 °C. After the dropwise addition, the mixture was stirred at 0 °C for 30 min. Subsequently, a one-time addition of aqueous potassium iodide solution (23.7 g, 143.0 mmol dissolved in 77 mL of water) was added. The ice bath was removed and the reaction mixture continued to be stirred for 2.5 hours. Then, the mixture was heated to 60 °C maintained for 0.5 h until nitrogen gas stopped being produced. After completion of the reaction, it was cooled to room temperature and extracted three times with ether. The organic layer was washed sequentially with 5% aqueous sodium thiosulfate (100 mL x 3) and saturated brine (100 mL x 2). The organic layer was dried over sodium sulfate and filtered, and the filtrate was concentrated to obtain a red oil. The oily substance was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=9/1) to give a light orange solid. Further recrystallization with 2-propanol gave pale orange crystalline compound (2) (yield: 11.4 g, 35.2%). The structure of compound (2) was confirmed by the following analytical results: 1H NMR (500 MHz, CDCl3, TMS, δ): 2.13 (quintuple peak, 2H, J=5.7 Hz), 2.64 (t, 2H, J=6.3 Hz), 2.92 (t, 2H, J=6.0 Hz), 7.66 (d, 1H, J=8.0 Hz), 7.67 (s , 1H), 7.72 (d, 1H, J=8.0Hz); melting point: 74.0°C-75.0°C; mass spectrum: GC-MS m/z=272 (M+). The analytical results were consistent with the structure of compound (2).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 11, p. 3436 - 3440
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 9, p. 3309 - 3320
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 19, p. 4119 - 4130
[4] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 3, p. 283 - 288
[5] Patent: WO2011/158953, 2011, A1. Location in patent: Page/Page column 144-146
6-Iodo-1-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Iodo-1-tetralone manufacturers
- Product
- 6-Iodo-1-tetralone 340825-13-0
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-30
- Product
- 6-Iodo-1-tetralone 340825-13-0
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 200kgs
- Release date
- 2020-01-09