Thieno[2,3-d]pyrimidin-4(3H)one

Product Name: Thieno[2,3-d]pyrimidin-4(3H)one
CAS No.: 14080-50-3
Chemical Name: Thieno[2,3-d]pyrimidin-4(3H)one
Synonyms: 3,4-Dihyd;thieno[2,3-d]pyrimidin-4-ol;6-CHLORO-3-FLUORO-1H-INDAZOLE;ieno[2,3-d]pyriMidin-4(3H)one;3H-thieno[2,3-d]pyrimidin-4-one;Thieno[2,3-d]pyrimidin-4(3H)-one;Thieno[2,3-d]pyrimidin-4(1H)-one;3H-Thieno[2,3-d]pyrimidine-4-one;1H,4H-THIENO[2,3-D]PYRIMIDIN-4-ONE;3H-Thieno[2,3-d]pyrimidine-4-one
CBNumber: CB1956232
Molecular Formula: C6H4N2OS
Formula Weight: 152.17
MOL File: 14080-50-3.mol

More

Less

Thieno[2,3-d]pyrimidin-4(3H)one Property

Melting point:: 262-265°C
Boiling point:: 391.1±15.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in DMSO, Methanol
form: powder to crystal
pka: 10.84±0.20(Predicted)
color: Light yellow to Brown
InChI: InChI=1S/C6H4N2OS/c9-5-4-1-2-10-6(4)8-3-7-5/h1-3H,(H,7,8,9)
InChIKey: JEDVKUHCDPPWNR-UHFFFAOYSA-N
SMILES: C1=NC(=O)C2C=CSC=2N1
CAS DataBase Reference: 14080-50-3

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0205
Product name: 3,4-Dihydro-4-oxothieno[2,3-d]pyrimidine
Purity: AldrichCPR
Packaging: 1g
Price: $107
Updated: 2025/07/31

TCI Chemical

Product number: T3792
Product name: Thieno[2,3-d]pyrimidin-4(1H)-one
Packaging: 1G
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: T3792
Product name: Thieno[2,3-d]pyrimidin-4(1H)-one
Packaging: 5G
Price: $164
Updated: 2025/07/31

TRC

Product number: H961750
Product name: 4-Hydroxythieno[2,3-d]pyrimidine
Packaging: 500mg
Price: $50
Updated: 2021/12/16

TRC

Product number: H961750
Product name: 4-Hydroxythieno[2,3-d]pyrimidine
Packaging: 10g
Price: $620
Updated: 2021/12/16

More

Less

Thieno[2,3-d]pyrimidin-4(3H)one Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

4-Hydroxythieno[2,3-d]pyrimidine (cas# 14080-50-3) is a compound useful in organic synthesis.

Synthesis

4651-81-4

77287-34-4

14080-50-3

Thieno[2,3-d]pyrimidin-4(3H)-one was synthesized from methyl 2-aminothiophene-3-carboxylate (3.0 g, 19.1 mmol) and formamide (95 ml) by heating and reacting at 190 °C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and poured into water. The precipitate was collected by filtration, washed with water and dried. The crude product was purified by silica gel column chromatography (eluent: CH2Cl2/MeOH = 50:1) to afford the target compound thieno[2,3-d]pyrimidin-4(3H)-one as a white solid (1.93 g, 66% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO, 25 °C) and HRMS: 1H NMR δ= 12.49 (s, 1H, NH), 8.13 (s, 1H, CH), 7.58 (d, J = 5.8 Hz, 1H, CH), 7.39 (d, J = 5.8 Hz, 1H, CH) ppm; HRMS (calculated) C6H5N2OS: 153.01226, measured value: 153.01155).

References

[1] Patent: US2012/46278, 2012, A1. Location in patent: Page/Page column 81
[2] Patent: US2013/190297, 2013, A1. Location in patent: Paragraph 1205; 1206; 1207
[3] Patent: US2014/88088, 2014, A1. Location in patent: Paragraph 1220-1222
[4] Patent: CN107573386, 2018, A. Location in patent: Paragraph 0048-0050
[5] Tetrahedron, 2012, vol. 68, # 45, p. 9226 - 9233

Thieno[2,3-d]pyrimidin-4(3H)one Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Thieno[2,3-d]pyrimidin-4(3H)one Suppliers

Canada 1 China 181 India 3 Japan 1 United Kingdom 2 United States 13 Global 201

Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.

Tel: 0515-89701588 13770166955
Fax: 0515-87400189
Email: orgunion@orgunion.com
Country: China
ProdList: 620
Advantage: 55

Hefei Xiuhe Biotechnology Co. Ltd.

Tel: 0551-62887095 13856031416
Email: lism@xhbiotech.com
Country: China
ProdList: 213
Advantage: 58

Wuxi KaideRui Pharmaceutical Technology Co., Ltd

Tel: 19906241957
Fax: -
Email: 1557216087@qq.com
Country: China
ProdList: 1837
Advantage: 55

Nantong Flying Pharmtech Co., Ltd.

Tel: 13270692087
Fax: -
Email: 2488110388@qq.com
Country: China
ProdList: 32
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Shanghai Sinch Parmaceuticals Tech. Co. Ltd.

Tel: +86-21-54098501
Fax: +86-21-54096319
Email: sales@sinch.com.cn
Country: China
ProdList: 11598
Advantage: 64

More

Less

View Lastest Price from Thieno[2,3-d]pyrimidin-4(3H)one manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Thieno[2,3-d]pyrimidin-4(3H)one 14080-50-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Career Henan Chemical Co

Product: Thieno[2,3-d]pyrimidin-4(3H)one 14080-50-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-09

14080-50-3, Thieno[2,3-d]pyrimidin-4(3H)oneRelated Search:

2,4-Dihydroxythieno[2,3-d]pyrimidine THIENO[2,3-B]PYRAZIN-7-AMINE Thieno[3,2-d]pyrimidine-4-carboxylic acid Thieno[2,3-b]pyridine (8CI,9CI) thieno[2,3-b]pyridin-4-ol Methyl thieno[2,3-b]pyridine-2-carboxylate thieno[2,3-d]thiazol-2-amine 5-[(tert-butoxy)carbonyl]-3-Methyl-4H,5H,6H,7H- thieno[3,2-c]pyridine-2-carboxylic acid ethyl 3-aMino-6-(trifluoroMethyl)thieno[2,3- b]pyridine-2-carboxylate 4-HYDROXYTHIENO[3,2-C]PYRIDINE 4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBONITRILE THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE Thiazolo[5,4-c]pyridin-2-amine, 6-methoxy- 7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE 2-(TRIFLUOROMETHYL)THIENO[3,2-D]PYRIMIDIN-4-OL 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione 5-(4-FLUOROPHENYL)-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE 5-thien-2-ylthieno[2,3-d]pyrimidin-4(3H)-one

4-Hydroxythieno[2,3-d]pyrimidine, Thieno[2,3-d]pyrimidin-4(1H)-one

Thieno[2,3-d]pyrimidin-4(1H)-one

3,4-Dihyd

Thieno[2,3-d]pyrimidin-4(3H)-one

thieno[2,3-d]pyrimidin-4-ol

3H-Thieno[2,3-d]pyrimidine-4-one

ieno[2,3-d]pyriMidin-4(3H)one

3,4-Dihydro-4-oxothieno[2,3-d]pyrimidine

3<i>H</i>-Thieno[2,3-d]pyrimidine-4-one

6-CHLORO-3-FLUORO-1H-INDAZOLE

1H,4H-THIENO[2,3-D]PYRIMIDIN-4-ONE

Thieno[2,3-d]pyrimidin-4(3H)one ISO 9001：2015 REACH

3H-thieno[2,3-d]pyrimidin-4-one

Thieno[2,3-d]pyrimidin-4(1H)-one (9CI, ACI)

Thiopheno [2,3-d] pyrimidin-4 (3H) - one

Thieno-[2, 3-d] pyrimidine-4 (3H) -ketone

3,4-Dihydro-4-oxothieno[2,3-<i>d</i>]pyrimidine

14080-50-3

Fused Ring Systems

Bases & Related Reagents

Heterocycles

Nucleotides

Thiophene