Undecylenoyl phenylalanine
- Product Name
- Undecylenoyl phenylalanine
- CAS No.
- 175357-18-3
- Chemical Name
- Undecylenoyl phenylalanine
- Synonyms
- Sepiwhite;LGB UP;Sepiwhite MSH powder ;UNDECYLENOYL PHENYLALANINE;Undecarbonyl phenylalanine;Undecylenoyl Phenylalanine/MSH;Triethyl orthoformate 122-51-0;UNDECYLENOYL PHENYLALANINE USP/EP/BP;UNDECYLENOYL PHENYLALANINE(175357-18-3);N-(1-Oxo-10-undecen-1-yl)-L-phenylalanine
- CBNumber
- CB1965399
- Molecular Formula
- C20H29NO3
- Formula Weight
- 331.45
- MOL File
- 175357-18-3.mol
Undecylenoyl phenylalanine Property
- Melting point:
- 109-112 °C
- Boiling point:
- 540.0±50.0 °C(Predicted)
- Density
- 1.047±0.06 g/cm3(Predicted)
- vapor pressure
- 0-0Pa at 25-60℃
- pka
- 3.63±0.10(Predicted)
- InChI
- InChI=1S/C20H29NO3/c1-2-3-4-5-6-7-8-12-15-19(22)21-18(20(23)24)16-17-13-10-9-11-14-17/h2,9-11,13-14,18H,1,3-8,12,15-16H2,(H,21,22)(H,23,24)/t18-/m0/s1
- InChIKey
- RTBWWWVNZWFNBV-SFHVURJKSA-N
- SMILES
- C(O)(=O)[C@H](CC1=CC=CC=C1)NC(=O)CCCCCCCCC=C
- LogP
- -0.04-3.3 at pH2-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
Undecylenoyl phenylalanine Chemical Properties,Usage,Production
Description
Undecylenoyl Phenylalanine is a chemical compound—a substituted amino acid derivative—that is used in skin conditioning agents in different brands of whitening creams and other skin care topical products. The compound helps regulate skin pigmentation, thereby, improving skin tone and its fairness.
Undecylenoyl phenylalanine is a possible antagonist of alpha-melanocyte-stimulatinghormone. It inhibits melanotropin, a melanin stimulator found in the skin. Melanotropin controls tyrosinase activity (tyrosinase being an essential enzyme in the production of melanin), melanin (eumalanin) synthesis and melanosome; therefore, by preventing the production of melanotropin, the pigmentation process is reduced or halted.
Uses
Undecylenoyl phenylalanine is a novel skin-lightening agent, probably acting as α-melanocyte-stimulating hormone (α-MSH) and beta-adrenergic receptor (β-ADR) antagonist.
benefits
Undecylenoyl Phenylalanine has good skin affinity and can control the binding of α-MSH (melanocyte-stimulating hormone) to melanin production factors, thus blocking the process of melanin formation. It can exert a blocking effect on α-MSH at a concentration of 0.001%, while the optimal use concentration is 1%. It can comprehensively inhibit melanin production at multiple levels, resulting in more significant and long-lasting effects.
Clinical Use
A study was done to evaluate the efficacy and safety of a preparation containing undecylenoyl phenylalanine 2% in the topical treatment of solar lentigines. In total, 36 patients with solar lentigines of the hands were randomly assigned to apply the active preparation on one side and the vehicle alone on the other side, twice daily for 12 weeks. Undecylenoyl phenylalanine 2% is a novel depigmenting agent, which possibly acts as an alpha-melanocyte-stimulating hormone antagonist, thus inhibiting melaninogenesis. It achieved a significant lightening of the lesions with minimal side-effects. Most patients were satisfied with the improvement.
Side effects
When taken by mouth: L-phenylalanine is LIKELY SAFE for most people when taken in amounts commonly found in foods. L-phenylalanine is POSSIBLY SAFE when taken as medicine, short-term. D-phenylalanine is POSSIBLY SAFE when used as a single dose of up to 10 grams. There isn't enough reliable information to know if D-phenylalanine is safe when used as more than a single dose.
Mode of action
Undecylenoyl Phenylalanine is a structural analogue of α-MSH that competitively binds to the melanocortin-1 receptor (MC1-R) on melanocytes, leading to the suppression of melanocyte activity and reduced melanin production by inhibiting the production of tyrosinase.
Undecylenoyl phenylalanine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Undecylenoyl phenylalanine manufacturers
- Product
- UNDECYLENOYL PHENYLALANINE 175357-18-3
- Price
- US $100.00-60.00/kg
- Min. Order
- 100kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-06
- Product
- Undecylenoyl Phenylalanine 175357-18-3
- Price
- US $18.00-18.00/kg
- Min. Order
- 1kg
- Purity
- 99.9
- Supply Ability
- 5000
- Release date
- 2024-05-10
- Product
- Undecylenoyl Phenylalanine Sepiwhite 175357-18-3
- Price
- US $18.00-18.00/kg
- Min. Order
- 1kg
- Purity
- 99.9
- Supply Ability
- 5000
- Release date
- 2024-05-07