Cyclobutylmethylamine hydrochloride
- Product Name
- Cyclobutylmethylamine hydrochloride
- CAS No.
- 5454-82-0
- Chemical Name
- Cyclobutylmethylamine hydrochloride
- Synonyms
- C-Cyclobutyl-methylamine;CyclobutylMethylaMine, HCl;CyclobutaneMethanaMine HCl;(aMinoMethyl)cyclobutane hcl;Cyclobutylmethylamine hydrochloride;CyclobutaneMethanaMine hydrochloride;1-CyclobutylMethylaMine hydrochloride;(AMinoMethyl)cyclobutane hydrochloride;CyclobutaneMethanaMine, hydrochloride (1:1)
- CBNumber
- CB1967560
- Molecular Formula
- C5H12ClN
- Formula Weight
- 121.61
- MOL File
- 5454-82-0.mol
Cyclobutylmethylamine hydrochloride Property
- Melting point:
- >212°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Off-White to Pale Beige
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C5H11N.ClH/c6-4-5-2-1-3-5;/h5H,1-4,6H2;1H
- InChIKey
- JVZOVVGVPJVLSL-UHFFFAOYSA-N
- SMILES
- C(C1CCC1)N.Cl
- CAS DataBase Reference
- 5454-82-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C986020
- Product name
- CyclobutylmethylamineHydrochloride
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C986020
- Product name
- CyclobutylmethylamineHydrochloride
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- OR308087
- Product name
- 1-Cyclobutylmethanaminehydrochloride
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 069189
- Product name
- Cyclobutanemethanamine hydrochloride
- Purity
- >95%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 3230-5-03
- Product name
- Cyclobutylmethanamine hydrochloride
- Packaging
- 1g
- Price
- $53
- Updated
- 2021/12/16
Cyclobutylmethylamine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
4426-11-3
5454-82-0
General procedure for the synthesis of cyclobutylmethylamine hydrochloride from cyclobutanecarbonitrile: A tetrahydrofuran solution of borane (1 M, 296 mL, 296 mmol) was slowly added to a tetrahydrofuran (60 mL) solution of cyclobutanecarbonitrile (20 g, 247 mmol) under argon protection. The reaction mixture was heated to reflux and kept overnight. Upon completion of the reaction, the mixture was cooled in an ice-water bath and methanol (120 mL) was added slowly and dropwise, controlling the reaction temperature below 20 °C. Subsequently, a methanolic solution of 4M hydrochloric acid (300mL) was added and the temperature continued to be controlled below 20°C. The resulting solution was heated and refluxed for 2.5 hours. At the end of the reaction, the mixture was cooled and concentrated. The residue was diluted with methanol (100 mL) and concentrated again and the process was repeated. Ether was added to the residue, stirred for 30 min and filtered to give the title compound cyclobutylmethylamine hydrochloride (25.9 g, 86% yield) as a white solid. NMR hydrogen spectrum (300 MHz, DMSO-d6) δ ppm: 1.70-1.86 (m, 4H), 1.97-2.04 (m, 2H), 2.46-2.61 (m, 1H), 2.75-2.84 (m, 2H), 8.02 (br s, 3H).
References
[1] Patent: WO2015/25164, 2015, A1. Location in patent: Paragraph 59
[2] Patent: US2015/57298, 2015, A1. Location in patent: Page/Page column 19
[3] Patent: WO2011/97491, 2011, A1. Location in patent: Page/Page column 71-72
[4] Patent: WO2005/75464, 2005, A1. Location in patent: Page/Page column 22
[5] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 59
Cyclobutylmethylamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclobutylmethylamine hydrochloride manufacturers
- Product
- Cyclobutylmethylamine hydrochloride 5454-82-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-04
- Product
- Cyclobutylmethylamine hydrochloride 5454-82-0
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg；10kg; 25kg
- Release date
- 2020-01-07