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HYDROXYFASUDIL MONOHYDROCHLORIDE

Product Name
HYDROXYFASUDIL MONOHYDROCHLORIDE
CAS No.
155558-32-0
Chemical Name
HYDROXYFASUDIL MONOHYDROCHLORIDE
Synonyms
Fasudil Hydroxy;Hydroxyfasudil HCl;Fasudil Impurity 7 HCl;Hydroxyfasudil (HA-1100);Hydroxyfasudil HCl (HA1100);Hydroxyfasudil Hydrochloride;Hydroxyfasudil (HA-1100) HCl;HYDROXYFASUDIL MONOHYDROCHLORIDE;Hydroxyfasudil hydrochloride hydrate;HA 1100 hydrochloride (Hydroxyfasudil)
CBNumber
CB1973040
Molecular Formula
C14H18ClN3O3S
Formula Weight
343.82902
MOL File
155558-32-0.mol
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HYDROXYFASUDIL MONOHYDROCHLORIDE Property

Melting point:
>250 (dec.)
storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: >5mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (20mM)
InChIKey
XWWFOUVDVJGNNG-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H4413
Product name
Hydroxyfasudil hydrochloride hydrate
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$286
Updated
2024/03/01
Sigma-Aldrich
Product number
390602
Product name
Hydroxyfasudil
Packaging
2mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
14413
Product name
HA-1100 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14413
Product name
HA-1100 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
H4413
Product name
Hydroxyfasudil hydrochloride hydrate
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$1080
Updated
2024/03/01
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HYDROXYFASUDIL MONOHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo.

General Description

A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C

HYDROXYFASUDIL MONOHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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HYDROXYFASUDIL MONOHYDROCHLORIDE Suppliers

Canada 1 China 74 Europe 1 India 4 Japan 1 Switzerland 1 United Kingdom 1 United States 17 Global 100
SIGMA-RBI
Tel
--
Fax
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Country
Switzerland
ProdList
6896
Advantage
91

155558-32-0, HYDROXYFASUDIL MONOHYDROCHLORIDERelated Search:

5-Quinolinesulfonic acid, 2-methyl- Fasudil Pyridine N-Oxide TFA Salt 1,4-ditosyl-1,4-diazepane Fasudil diMer Fasudil Impurity 6 Fasudil Impurity 13 Fasudil N-hydroxy iMpurity 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol quinoline-5-sulphonic acid Fasudil Impurity 8-Methylquinoline 2-METHYLQUINOLINE-6-SULFONIC ACID Quinoline Fasudil IMpurity 3 1-(p-Toluenesulfonyl)hoMopiperazine, 95% Isoquinoline Fasudil Impurity 8 N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE

  • HA-1100 HYDROCHLORIDE;HA 1100 HYDROCHLORIDE;HA1100 HYDROCHLORIDE
  • 5-(1,4-diazepan-1-ylsulfonyl)-2h-isoquinolin-1-one
  • Hydroxyfasudil hydrochloride (HA-1100 hydrochloride)
  • Hydroxyfasudil - CAS 155558-32-0 - Calbiochem
  • Hydroxyfasudil HCl
  • 5-[(Hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
  • Hydroxyfasudil Hydrochloride
  • 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride
  • HYDROXYFASUDIL MONOHYDROCHLORIDE
  • Hydroxyfasudil hydrochloride hydrate,1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
  • 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate
  • Hydroxyfasudil hydrochloride hydrate
  • Hydroxyfasudil (HA-1100)
  • Hydroxyfasudil (HA-1100) HCl
  • 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)
  • Fasudil Impurity 7 HCl
  • Fasudil Hydroxy
  • 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol hydrochloride
  • 5-[(1,4-Diazepan-1-yl)sulfonyl]isoquinolin-1(2H)-one Hydrochloride
  • Hydroxyfasudil HCl (HA1100)
  • 5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one,hydrochloride
  • HA-1100,ROCK,Hydroxyfasudil Hydrochloride,Hydroxyfasudil,Rho-associated kinase,HA 1100,inhibit,HA1100,Rho-kinase,Rho-associated protein kinase,ROK,Inhibitor
  • Hydroxyfasudil hydrochloride hydrate Hydroxyfasudil hydrochloride
  • HA 1100 hydrochloride (Hydroxyfasudil)
  • 155558-32-0
  • C14H17N3O3SHCl
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals