LUMIRACOXIB

Product Name: LUMIRACOXIB
CAS No.: 220991-20-8
Chemical Name: LUMIRACOXIB
Synonyms: Prexige;COX 189;CGS 35189;Lumaricoxib;LUMIRACOXIB;Unii-V91T9204hu;Prexige, Lumiracoxib;Xanthine Impurity 30;LuMiracoxib (COX-189);Lumiracoxib (CGS 35189
CBNumber: CB21006324
Molecular Formula: C15H13ClFNO2
Formula Weight: 293.72
MOL File: 220991-20-8.mol

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LUMIRACOXIB Property

Melting point:: 139-141°C
Boiling point:: 395.7±42.0 °C(Predicted)
Density: 1.363±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≥29.4 mg/mL in DMSO; insoluble in H2O; ≥27.15 mg/mL in EtOH with ultrasonic
form: solid
pka: 4.18±0.10(Predicted)
color: White to light yellow
CAS DataBase Reference: 220991-20-8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2928
Product name: Lumiracoxib
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $46.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2928
Product name: Lumiracoxib
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $191
Updated: 2024/03/01

Cayman Chemical

Product number: 27645
Product name: Lumiracoxib
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27645
Product name: Lumiracoxib
Packaging: 50mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 27645
Product name: Lumiracoxib
Packaging: 100mg
Price: $153
Updated: 2024/03/01

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LUMIRACOXIB Chemical Properties,Usage,Production

Description

As a second-generation, selective cyclooxygenase (COX-2) inhibitor, lumiracoxib is devoid of the gastrointestinal issues that plague other non-selective, nonsteroidal, anti-inflammatory drugs (NSAIDs) that crossover to COX-1. As an inhibitor of the inducible COX-2 that is up-regulated in pathological processes of pain and inflammation, lumiracoxib blocks the conversion of arachidonic acid to prostaglandins, the mediators of the pathological effects. It’s mode of binding to COX-2 has been found to differ from the other selective COX-2 inhibitors; the carboxylic acid forms hydrogen bonds with Tyr-385 and Ser-530 in the catalytic site rather than seeking interactions within the larger hydrophobic side pocket. Since lumiracoxib is mainly metabolized by CYP2C9, a study evaluating the co-administration of lumiracoxib with fluconazole, a potent inhibitor of CYP2C9, was conducted, and it concluded that there was no need for lumiracoxib dose adjustment, since changes in the systemic exposure were not significant. No serious adverse effects were reported, but in the small number of cases where treatment was discontinued, Gastro intestinal (GI) and musculoskeletal complaints were common.

Description

Lumiracoxib is a selective inhibitor of COX-2 with IC₅₀ values of 0.13 and 67 μM for COX-2 and COX-1, respectively, in isolated human whole blood. It reduces increases in the levels of prostaglandin E₂ (PGE₂; ) induced by IL-1β in human dermal fibroblasts (IC₅₀ = 0.14 μM), as well as in LPS-stimulated RAW 264.7 cells when used at concentrations ranging from 1 to 100 μM., Lumiracoxib (3 and 10 mg/kg) also decreases LPS-induced increases in the levels of PGE₂ in a rat model of air pouch inflammation. It reduces M. tuberculosis-induced increases in hind paw volume and the radiological and histopathological severity of arthritic lesions in a rat model of chronic arthritis when administered at a dose of 2 mg/kg.

Chemical Properties

Pale Yellow Solid

Originator

Novartis AG (Switzerland)

Uses

Lumiracoxib is a selective cyclooxygenase-2-(COX-2) inhibitor and an anti-inflammatory agent (1,2,3,4).

Uses

Selective cyclooxygenase-2-(COX-2) inhibitor. Anti-inflammatory.

Uses

antiinflammatory, analgesic, antiarthritic

Definition

ChEBI: An amino acid that is phenylacetic acid which is substituted at position 2 by the nitrogen of 2-chloro-6-fluoroaniline and at position 5 by a methyl group. A highly selective cyclooxygenase 2 inhibitor, it was briefly used for the treatment of osteoarthrit s, but was withdrawn due to concersns of hepatotoxicity.

brand name

Prexige

Biochem/physiol Actions

Lumiracoxib (COX189) is an orally active, potent and selective cyclooxygenase-2 inhibitor (Ki = 60 nM/COX-2 vs. 3.2 μM/COX-1) that inhibits COX-2-mediated PGE2 production in human whole blood (IC50 = 130 nM; stimulation = 50 μM A23187), but not COX-1-dependent TxB2 production (IC50 = 67 μM; stimulation = 10 μg/mL LPS). Lumiracoxib shows in vivo anti-inflammatory efficacy against carrageenan-induced paw oedema (ED30 = 0.35 mg/kg p.o.), CFA-induced hyperalgesia (ED30 = 5.1 mg/kg p.o.), as well as adjuvant-induced arthritis (ED50 = 3 mg/kg/day p.o.) in rats in vivo.

LUMIRACOXIB Preparation Products And Raw materials

Raw materials

Preparation Products

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LUMIRACOXIB Suppliers

Canada 2 China 98 Europe 2 Germany 2 India 6 Switzerland 2 United Kingdom 6 United States 20 Global 138

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View Lastest Price from LUMIRACOXIB manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: LUMIRACOXIB 220991-20-8
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Hebei Mojin Biotechnology Co., Ltd

Product: LUMIRACOXIB 220991-20-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-28

Longyan Tianhua Biological Technology Co., Ltd

Product: LUMIRACOXIB 220991-20-8
Price: US $30.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99
Supply Ability: 999
Release date: 2020-11-09

220991-20-8, LUMIRACOXIBRelated Search:

Esomeprazole Apremilast Indole Cimetidine Rofecoxib Epi-Lacosamide-d3 (1.0 mg/mL in Acetonitrile) Dibutyl phosphate 6-HYDROXYWARFARIN 4-AMINOAZOBENZENE CBPNZQVSJQDFBE-VUWIKSLBSA-N Tolclofos-methyl Diflunisal Impurity 1 (2-Fosfomycinyl-1-(hydroxy)propyl)phosphonic Acid diisopentyl phthalate SiraMesine, Lu-28-179 ACRYLAMIDE-2,3,3-D3 Tributyl phosphate Isopentyl Pentyl Phthalate

2-[2-[(2-chloro-6-fluoro-phenyl)amino]-5-methyl-phenyl]acetic acid

2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic Acid

CGS 35189

COX 189

Prexige

Lumaricoxib

Benzeneacetic acid, 2-((2-chloro-6-fluorophenyl)amino)-5-methyl-

Unii-V91T9204hu

Lumiracoxib, COX-189, Prexige

LuMiracoxib (COX-189)

2-(5-((2-chloro-6-fluorophenyl)amino)-2-methylphenyl)acetic acid

2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid

Lumiracoxib (CGS 35189

2-[2-(2-Chloro-6-fluorophenylamino)-5-methylphenyl]acetic ac...

Prexige, Lumiracoxib

Cyclooxygenase,Inhibitor,bone cancer,osteoarthritis,inflammatory,COX189,inhibit,hyperalgesic,COX 189,Lumiracoxib,COX,Metabolic Syndrome

Xanthine Impurity 30

LUMIRACOXIB

220991-20-8

C15H13ClFNO2

Inhibitors

PREXIGE

Aromatics Compounds

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals