ChemicalBook > CAS DataBase List > PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO-

PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO-

Product Name
PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO-
CAS No.
152811-62-6
Chemical Name
PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO-
Synonyms
CS-2135;Sb207256;PIBOSEROD;SB 207266;Unii-4uq3S81B25;Piboserod [inn];SB207266(Piboserod);Piboserod(SB-207266);SB-207266 >=98% (HPLC);Piboserod, 10 mM in DMSO
CBNumber
CB21011579
Molecular Formula
C22H31N3O2
Formula Weight
369.5
MOL File
152811-62-6.mol
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PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO- Property

Melting point:
110-113°
Boiling point:
570.3±35.0 °C(Predicted)
Density 
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 30 mg/mL; DMSO: 20 mg/mL; Ethanol: 30 mg/mL; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/mL
pka
13.86±0.20(Predicted)
form 
powder
color 
white to beige
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Safety

RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1349
Product name
SB-207266
Purity
≥98% (HPLC)
Packaging
5mg
Price
$111
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1349
Product name
SB-207266
Purity
≥98% (HPLC)
Packaging
25mg
Price
$336
Updated
2025/07/31
Cayman Chemical
Product number
18778
Product name
SB-207266
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18778
Product name
SB-207266
Purity
≥95%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
18778
Product name
SB-207266
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
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PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO- Chemical Properties,Usage,Production

Uses

Treatment of irritable bowel syndrome (selective 5HT4receptor antagonist).

Uses

Piboserod is a 5-HT4 receptor antagonist which has shown positive results as a Hepatitis C virus (HCV) entry inhibtor.

Biochem/physiol Actions

SB-207266 is a potent, selective, orally active and long-acting 5-HT4 antagonist in vivo.

in vivo

Piboserod (0.3-30mg/kg oral, 0.1mg/kg subcutaneous) can inhibit the gastric fundus contraction response induced by the 5-HT2B receptor agonist BW 723C86 in rat and mouse models, and can also inhibit the esophageal relaxation response induced by the 5-HT4 receptor agonist (such as Tegaserod); in mouse experiments, it can dose-dependently reduce the concentration of SB207145 in the rat striatum, thereby affecting the occupancy of 5-HT4 receptors[3][4].

Animal Model:Sprague-Dawley rats (male, 250-350 g), mice models[3][4]
Dosage:0.3-30 mg/kg for oral administration, 0.1 mg/kg for subcutaneous injection.
Administration:Oral or subcutaneous injection
Result:Attenuated the BW 723C86-mediated contractile responses of the stomach fundus in Sprague-Dawley rats.
Abolished the Tegaserod (0.001-0.3 mg/kg intravenously)-mediated oesophageal relaxation responses in mice.
Dose-dependently decreased the concentrations of SB207145 in the rat striatum, and the effective dose to achieve 50% receptor occupancy with an ED50 of 2.0 mg/kg .

IC 50

5-HT4 Receptor

PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO- Preparation Products And Raw materials

Raw materials

Preparation Products

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PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO- Suppliers

China 63 The Netherlands 1 United States 8 Global 72
Axon Medchem BV
Tel
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Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30
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View Lastest Price from PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO- manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Piboserod 152811-62-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Piboserod 152811-62-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO- 152811-62-6
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-25

152811-62-6, PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO-Related Search:

PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO- 4-Acetylaminomethyl Piperidine (1-Methyl-1H-indol-3-yl)-methylamine 1H-Indole-3-carboxamide(9CI) 1H-indol-2-ol 1-METHYL-1H-INDOL-2-OL

  • PIBOSEROD,2H-(1,3)OXAZINO(3,2-A)INDOLE-10-CARBOXAMIDE, N-((1-BUTYL-4-PIPERIDINYL)METHYL)-3,4-DIHYDRO-
  • PIBOSEROD
  • Piboserod(SB-207266)
  • Piboserod [inn]
  • Sb207256
  • Unii-4uq3S81B25
  • SB 207266
  • SB207266(Piboserod)
  • 2H-[1,3]Oxazino[3,2-a]indole-10-carboxamide,N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-
  • N-[(1-Butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide
  • N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide
  • CS-2135
  • SB-207266;SB 207266;SB207266
  • SB-207266 >=98% (HPLC)
  • SB207266,Inhibitor,Piboserod,Serotonin Receptor,5-hydroxytryptamine Receptor,inhibit,SB 207266,5-HT Receptor
  • N-[(1-butylpiperidin-4-yl)methyl]-2H,3H,4H-[1,3]oxazino[3,2-a]indole-10-carboxamide
  • Piboserod, 10 mM in DMSO
  • 152811-62-6
  • Inhibitors
  • API