Amprolium Hydrochloride
- Product Name
- Amprolium Hydrochloride
- CAS No.
- 137-88-2
- Chemical Name
- Amprolium Hydrochloride
- Synonyms
- AMPROLIUM HCL;Amprolio;2-picolinium,1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-,chloride,monohydroc;amprol;amprol25;mepyrium;Amprovine;Ampomycin;CB2101848;thiacoccid
- CBNumber
- CB2101848
- Molecular Formula
- C14H20Cl2N4
- Formula Weight
- 315.24
- MOL File
- 137-88-2.mol
Amprolium Hydrochloride Property
- Melting point:
- 239.0 to 243.0 °C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Powder
- color
- White to Off-white
- BRN
- 4118699
- InChI
- InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
- InChIKey
- PJBQYZZKGNOKNJ-UHFFFAOYSA-M
- SMILES
- C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-]
- CAS DataBase Reference
- 137-88-2(CAS DataBase Reference)
- EPA Substance Registry System
- Amprolium hydrochloride (137-88-2)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 3
- RTECS
- TJ7565000
- HS Code
- 29335995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 31592
- Product name
- Amprolium hydrochloride
- Purity
- cationic
- Packaging
- 250mg
- Price
- $52.8
- Updated
- 2024/03/01
- Product number
- 1034002
- Product name
- Amprolium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $261.6
- Updated
- 2024/03/01
- Product number
- A2572
- Product name
- Amprolium Hydrochloride [for Biochemical Research]
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $25
- Updated
- 2024/03/01
- Product number
- A2572
- Product name
- Amprolium Hydrochloride [for Biochemical Research]
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- J64782
- Product name
- 1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium chloride
- Packaging
- 25g
- Price
- $90.2
- Updated
- 2023/06/20
Amprolium Hydrochloride Chemical Properties,Usage,Production
Description
Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.
Chemical Properties
Crystalline powder
Uses
Coccidiostatic;Thiamine transport inhibitor
Uses
Thiamine analog coccidiostat.
Uses
1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity.
Definition
MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism.
Contact allergens
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
Veterinary Drugs and Treatments
Amprolium has good activity against Eimeria tenella and E. acervulina
in poultry and can be used as a therapeutic agent for these
organisms. It only has marginal activity or weak activity
against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in
combination with other agents (e.g., ethopabate) to improve control
against those organisms.
In cattle, amprolium has approval for the treatment and prevention
of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the
control of coccidiosis, although there are no approved products in
the USA for these species.
Amprolium Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Amprolium Hydrochloride Suppliers
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View Lastest Price from Amprolium Hydrochloride manufacturers
- Product
- Amprolium Hydrochloride 137-88-2
- Price
- US $0.00/kg
- Min. Order
- 25kg
- Purity
- 98.0%~101.0%
- Supply Ability
- 10tons
- Release date
- 2024-04-26
- Product
- Amprolium Hydrochloride 137-88-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-04-24
- Product
- Amprolium hydrochloride 137-88-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2022-11-22