Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)

Product Name: Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
CAS No.: 265108-36-9
Chemical Name: Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
Synonyms: 4,4-Difluoro-cyclohexanecarbaldehyde;4,4-DIFLU0R0 CYCLOHEXANECARBOXALDEHYDE;Cyclohexanecarboxaldehyde, 4,4-difluor;4,4-difluorocyclohexane-1-carbaldehyde;4,4-Difluoro Cyclohexanecarboxaldehyde;Cyclohexanecarboxaldehyde, 4,4-difluoro-;4,4-difluorocyclohexane-1-carbaldehyde 95%;Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
CBNumber: CB21048522
Molecular Formula: C7H10F2O
Formula Weight: 148.15
MOL File: 265108-36-9.mol

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Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Property

Boiling point:: 165.0±40.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: solid
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C7H10F2O/c8-7(9)3-1-6(5-10)2-4-7/h5-6H,1-4H2
InChIKey: DNSDOTKSZMHDOR-UHFFFAOYSA-N
SMILES: C1(C=O)CCC(F)(F)CC1

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: MNO000202
Product name: 4,4-Difluorocyclohexanecarboxaldehyde
Packaging: 1g
Price: $427
Updated: 2025/07/31

TRC

Product number: D526223
Product name: 4,4-Difluorocyclohexanecarbaldehyde
Packaging: 100mg
Price: $90
Updated: 2021/12/16

TRC

Product number: D526223
Product name: 4,4-Difluorocyclohexanecarbaldehyde
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104547
Product name: 4,4-difluorocyclohexane-1-carbaldehyde
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 064642
Product name: 4,4-Difluorocyclohexanecarboxaldehyde
Purity: 97%
Packaging: 250mg
Price: $146
Updated: 2021/12/16

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Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Chemical Properties,Usage,Production

Uses

4,4-Difluorocyclohexanecarbaldehyde is used in the preparation of heteroaryl acid derivative and methods for treating oxalate-related diseases.

Synthesis

178312-48-6

265108-36-9

Oxalyl chloride (0.35 mL, 4.16 mmol) was dissolved in anhydrous dichloromethane (15.0 mL) under nitrogen protection and cooled to -78 °C. Subsequently, dimethyl sulfoxide (0.27 mL, 3.84 mmol) was slowly added dropwise and stirred at -78 °C for 15 min. Next, a solution of (4,4-difluorocyclohexyl)methanol (0.48 g, 3.20 mmol) in anhydrous dichloromethane (10 mL) was added dropwise. The reaction mixture was continued to be stirred at -78 °C for 1 hour. After that, triethylamine (1.27 mL, 9.60 mmol) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and subsequently concentrated to dryness under reduced pressure. The crude product was dissolved in ether (30 mL) and washed sequentially with saturated aqueous sodium bicarbonate solution and ammonium chloride solution (30 mL each). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4,4-difluorocyclohexanecarboxaldehyde (0.39 g, 82% yield), which could be used in subsequent reactions without further purification.1H NMR (DMSO-d6) δ: 9.61 (s, 1H), 2.05-1.73 (m, 7H), 1.64-1.51 (m, 2H).

References

[1] Patent: WO2014/144836, 2014, A2. Location in patent: Paragraph 0095; 0996
[2] European Journal of Medicinal Chemistry, 2016, vol. 111, p. 138 - 159
[3] Patent: WO2014/184561, 2014, A1. Location in patent: Page/Page column 72
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2780 - 2789
[5] Patent: WO2009/65035, 2009, A1. Location in patent: Page/Page column 81-82

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Suppliers

China 82 Europe 1 India 1 United Kingdom 1 United States 8 Global 93

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View Lastest Price from Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) 265108-36-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) 265108-36-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) 265108-36-9
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-02-04

265108-36-9, Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)Related Search:

Cyclohexanecarboxaldehyde 4,4-difluoroadamantane-1-carboxylic acid Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) METHYL PERFLUOROCYCLOHEXYL KETONE ETHYL 4,4-DIFLUOROCYCLOHEXANECARBOXYLATE 4,4-Difluorocyclohexanecarboxylic acid 9,9-difluorobicyclo[3.3.1]nonane-3-carboxylic acid PERFLUOROCYCLOHEXANECARBONYL CHLORIDE PERFLUOROCYCLOHEXANECARBOXYLIC ACID Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester PERFLUOROCYCLOHEXYL CARBOXYLIC ACID FLUORIDE 1-UNDECAFLUORO-CYCLOHEXYL-TRIFLUORO-1,3-BUTANEDIONE Maraviroc 1,3-BIS(PERFLUOROCYCLOHEXYL)-1,3-PROPANEDIONE Cyclohexanecarboxamide, 4,4-difluoro- PERFLUOROCYCLOHEXANECARBONYL BROMIDE

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)

4,4-Difluoro Cyclohexanecarboxaldehyde

4,4-difluorocyclohexane-1-carbaldehyde

Cyclohexanecarboxaldehyde, 4,4-difluoro-

4,4-Difluoro-cyclohexanecarbaldehyde

Cyclohexanecarboxaldehyde, 4,4-difluor

4,4-DIFLU0R0 CYCLOHEXANECARBOXALDEHYDE

4,4-difluorocyclohexane-1-carbaldehyde 95%

265108-36-9

C7H10F2O

HALIDE

ALDEHYDE