ChemicalBook > CAS DataBase List > Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)

Product Name
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
CAS No.
265108-36-9
Chemical Name
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
Synonyms
4,4-Difluoro-cyclohexanecarbaldehyde;4,4-DIFLU0R0 CYCLOHEXANECARBOXALDEHYDE;Cyclohexanecarboxaldehyde, 4,4-difluor;4,4-difluorocyclohexane-1-carbaldehyde;4,4-Difluoro Cyclohexanecarboxaldehyde;Cyclohexanecarboxaldehyde, 4,4-difluoro-;4,4-difluorocyclohexane-1-carbaldehyde 95%;Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
CBNumber
CB21048522
Molecular Formula
C7H10F2O
Formula Weight
148.15
MOL File
265108-36-9.mol
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Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Property

Boiling point:
165.0±40.0 °C(Predicted)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
solid
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C7H10F2O/c8-7(9)3-1-6(5-10)2-4-7/h5-6H,1-4H2
InChIKey
DNSDOTKSZMHDOR-UHFFFAOYSA-N
SMILES
C1(C=O)CCC(F)(F)CC1
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2913000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
MNO000202
Product name
4,4-Difluorocyclohexanecarboxaldehyde
Packaging
1g
Price
$427
Updated
2025/07/31
TRC
Product number
D526223
Product name
4,4-Difluorocyclohexanecarbaldehyde
Packaging
100mg
Price
$90
Updated
2021/12/16
TRC
Product number
D526223
Product name
4,4-Difluorocyclohexanecarbaldehyde
Packaging
50mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD104547
Product name
4,4-difluorocyclohexane-1-carbaldehyde
Packaging
500mg
Price
$200
Updated
2021/12/16
Matrix Scientific
Product number
064642
Product name
4,4-Difluorocyclohexanecarboxaldehyde
Purity
97%
Packaging
250mg
Price
$146
Updated
2021/12/16
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Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Chemical Properties,Usage,Production

Uses

4,4-Difluorocyclohexanecarbaldehyde is used in the preparation of heteroaryl acid derivative and methods for treating oxalate-related diseases.

Synthesis

178312-48-6

265108-36-9

Oxalyl chloride (0.35 mL, 4.16 mmol) was dissolved in anhydrous dichloromethane (15.0 mL) under nitrogen protection and cooled to -78 °C. Subsequently, dimethyl sulfoxide (0.27 mL, 3.84 mmol) was slowly added dropwise and stirred at -78 °C for 15 min. Next, a solution of (4,4-difluorocyclohexyl)methanol (0.48 g, 3.20 mmol) in anhydrous dichloromethane (10 mL) was added dropwise. The reaction mixture was continued to be stirred at -78 °C for 1 hour. After that, triethylamine (1.27 mL, 9.60 mmol) was added slowly and dropwise. The reaction mixture was gradually warmed to room temperature and subsequently concentrated to dryness under reduced pressure. The crude product was dissolved in ether (30 mL) and washed sequentially with saturated aqueous sodium bicarbonate solution and ammonium chloride solution (30 mL each). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4,4-difluorocyclohexanecarboxaldehyde (0.39 g, 82% yield), which could be used in subsequent reactions without further purification.1H NMR (DMSO-d6) δ: 9.61 (s, 1H), 2.05-1.73 (m, 7H), 1.64-1.51 (m, 2H).

References

[1] Patent: WO2014/144836, 2014, A2. Location in patent: Paragraph 0095; 0996
[2] European Journal of Medicinal Chemistry, 2016, vol. 111, p. 138 - 159
[3] Patent: WO2014/184561, 2014, A1. Location in patent: Page/Page column 72
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2780 - 2789
[5] Patent: WO2009/65035, 2009, A1. Location in patent: Page/Page column 81-82

Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) 265108-36-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) 265108-36-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) 265108-36-9
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-04

265108-36-9, Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)Related Search:

Cyclohexanecarboxaldehyde 4,4-difluoroadamantane-1-carboxylic acid Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI) METHYL PERFLUOROCYCLOHEXYL KETONE ETHYL 4,4-DIFLUOROCYCLOHEXANECARBOXYLATE 4,4-Difluorocyclohexanecarboxylic acid 9,9-difluorobicyclo[3.3.1]nonane-3-carboxylic acid PERFLUOROCYCLOHEXANECARBONYL CHLORIDE PERFLUOROCYCLOHEXANECARBOXYLIC ACID Cyclohexanecarboxylic acid, 4,4-difluoro-, methyl ester PERFLUOROCYCLOHEXYL CARBOXYLIC ACID FLUORIDE 1-UNDECAFLUORO-CYCLOHEXYL-TRIFLUORO-1,3-BUTANEDIONE Maraviroc 1,3-BIS(PERFLUOROCYCLOHEXYL)-1,3-PROPANEDIONE Cyclohexanecarboxamide, 4,4-difluoro- PERFLUOROCYCLOHEXANECARBONYL BROMIDE

  • Cyclohexanecarboxaldehyde, 4,4-difluoro- (9CI)
  • 4,4-Difluoro Cyclohexanecarboxaldehyde
  • 4,4-difluorocyclohexane-1-carbaldehyde
  • Cyclohexanecarboxaldehyde, 4,4-difluoro-
  • 4,4-Difluoro-cyclohexanecarbaldehyde
  • Cyclohexanecarboxaldehyde, 4,4-difluor
  • 4,4-DIFLU0R0 CYCLOHEXANECARBOXALDEHYDE
  • 4,4-difluorocyclohexane-1-carbaldehyde 95%
  • 265108-36-9
  • C7H10F2O
  • HALIDE
  • ALDEHYDE