Pyridine, 3-chloro-2-(chloromethyl)- (9CI)
- Product Name
- Pyridine, 3-chloro-2-(chloromethyl)- (9CI)
- CAS No.
- 185315-53-1
- Chemical Name
- Pyridine, 3-chloro-2-(chloromethyl)- (9CI)
- Synonyms
- 3-Chloro-2-(chloromethyl);3-Chloro-2-(chloroMethyl)pyridine;3-chloro-pyridin-2-ylMethyl chloride;Pyridine, 3-chloro-2-(chloromethyl)-;Pyridine, 3-chloro-2-(chloromethyl)- (9CI)
- CBNumber
- CB21057351
- Molecular Formula
- C6H5Cl2N
- Formula Weight
- 162.02
- MOL File
- 185315-53-1.mol
Pyridine, 3-chloro-2-(chloromethyl)- (9CI) Property
- Boiling point:
- 213.0±25.0 °C(Predicted)
- Density
- 1.324±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.43±0.22(Predicted)
N-Bromosuccinimide Price
- Product number
- C611240
- Product name
- 3-Chloro-2-(chloromethyl)pyridine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- C611240
- Product name
- 3-Chloro-2-(chloromethyl)pyridine
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- FC29745
- Product name
- 3-Chloro-2-(chloromethyl)pyridine
- Packaging
- 250mg
- Price
- $375
- Updated
- 2021/12/16
- Product number
- HCH0364746
- Product name
- 3-CHLORO-2-(CHLOROMETHYL)PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.92
- Updated
- 2021/12/16
- Product number
- FC29745
- Product name
- 3-Chloro-2-(chloromethyl)pyridine
- Packaging
- 50mg
- Price
- $160
- Updated
- 2021/12/16
Pyridine, 3-chloro-2-(chloromethyl)- (9CI) Chemical Properties,Usage,Production
Synthesis
60588-81-0
185315-53-1
General procedure for the synthesis of 3-chloro-2-(chloromethyl)pyridine from 3-chloropyridine-2-methanol: To a solution of compound 31 (300 mg, 2.1 mmol) in dichloromethane (DCM, 4 mL) was added N,N-diisopropylethylamine (DIE A, 539 mg, 4.2 mmol) at 0 °C, followed by slow dropwise addition of mesyl chloride (MsCl, 263 mg, 2.3 mmol). The reaction mixture was stirred at 0 °C for 3 hours. Upon completion of the reaction, the reaction was quenched by the addition of water and the mixture was extracted with dichloromethane. The organic phase was washed sequentially with saturated sodium bicarbonate (NaHCO3) solution and brine and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the filtrate was concentrated under reduced pressure to give compound 32 (240 mg, 69% yield) as a yellow oil.
References
[1] Patent: WO2015/143164, 2015, A1. Location in patent: Page/Page column 119-120
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 438 - 450
Pyridine, 3-chloro-2-(chloromethyl)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
Pyridine, 3-chloro-2-(chloromethyl)- (9CI) Suppliers
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 0571-82896630 18969958410
- sales_hz@milestonepharmtech.com
- Country
- China
- ProdList
- 4894
- Advantage
- 55
- Tel
- 0371-88888888 272369594
- Fax
- QQ:272369594
- 2723695949@qq.com
- Country
- China
- ProdList
- 4959
- Advantage
- 50
- Tel
- 13675155016
- Fax
- 18912765016
- tongtf110@sina.com
- Country
- China
- ProdList
- 963
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58