Mupadolimab

Product Name: Mupadolimab
CAS No.: 2451856-97-4
Chemical Name: Mupadolimab
Synonyms: CPI-006;Mupadolimab;Mupadolimab (anti-CD73);Research Grade Mupadolimab;Research Grade Mupadolimab(DHD46604)
CBNumber: CB210617076
Formula Weight: 0
MOL File: Mol file

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Mupadolimab Property

storage temp.: Store at -20°C
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Mupadolimab Chemical Properties,Usage,Production

Uses

Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti-CD73 monoclonal antibody (mAb) that activates CD73POS B cells[1].

in vivo

Mupadolimab (10 mg/kg; i.p.; daily for 15 days) stimulates antigen specific humoral immunity in SARS-CoV-2 infected NSG-SGM3 mice^[1].

Animal Model:	NSG-SGM3 mice, immunized with an emulsion of 50 μg full length spike protein from SARS-CoV-2 and Freund’s Incomplete Adjuvant subcutaneously on both the left and right flank (25 μg/side)^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection, daily for 15 days
Result:	Mice treated with the drug made antibodies to the immunizing TS protein; but not to the control nucleocapsid SARS-CoV-2 viral protein.

References

[1] Miller R A, et al. Clinical results with a B cell activating anti-CD73 antibody for the immunotherapy of Covid-19. medRxiv, 2021.

Mupadolimab Preparation Products And Raw materials

Raw materials

Preparation Products

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Mupadolimab Suppliers

China 15 United States 2 Global 17

Shanghai YuanYe Biotechnology Co., Ltd.

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2451856-97-4, MupadolimabRelated Search:

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Mupadolimab

Research Grade Mupadolimab(DHD46604)

Mupadolimab (anti-CD73)

CPI-006

Research Grade Mupadolimab

2451856-97-4