ChemicalBook > CAS DataBase List > 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
- Product Name
- 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
- CAS No.
- 137206-97-4
- Chemical Name
- 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
- Synonyms
- DPMQ;DMPQ2HCl;DMPQ DIHYDROCHLORIDE;5,7-dimethoxy-3-pyridin-4-ylquinoline;5,7-dimethoxy-3-(4-pyridinyl)quinoline;Quinoline, 5,7-dimethoxy-3-(4-pyridinyl)-;5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE;5,7-DiMethoxy-3-(pyridin-4-yl)quinoline dihydrochloride
- CBNumber
- CB2106454
- Molecular Formula
- C16H14N2O2
- Formula Weight
- 266.29
- MOL File
- 137206-97-4.mol
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5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Property
- Boiling point:
- 441.3±40.0 °C(Predicted)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 30 mg/ml).
- form
- solid
- pka
- 3.58±0.38(Predicted)
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
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N-Bromosuccinimide Price
Tocris
- Product number
- 1222
- Product name
- DMPQ dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $149
- Updated
- 2021/12/16
Tocris
- Product number
- 1222
- Product name
- DMPQ dihydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $567
- Updated
- 2021/12/16
Usbiological
- Product number
- 255176
- Product name
- DMPQ dihydrochloride
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- KIN0000096
- Product name
- DMPQ DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $665.81
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- KIN0000096
- Product name
- DMPQ DIHYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $135.45
- Updated
- 2021/12/16
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5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Description
DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.
Uses
DMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ).
Biological Activity
A potent and selective inhibitor of human vascular β -type platelet derived growth factor receptor tyrosine kinase (PDGFR β ) (IC 50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.
References
[1] J A BEAVO. Effects of xanthine derivatives on lipolysis and on adenosine 3’,5’-monophosphate phosphodiesterase activity.[J]. Molecular Pharmacology, 1970, 6 6: 597-603.
5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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137206-97-4, 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDERelated Search:
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5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE