5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE

Product Name: 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
CAS No.: 137206-97-4
Chemical Name: 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE
Synonyms: DPMQ;DMPQ2HCl;DMPQ DIHYDROCHLORIDE;5,7-dimethoxy-3-pyridin-4-ylquinoline;5,7-dimethoxy-3-(4-pyridinyl)quinoline;Quinoline, 5,7-dimethoxy-3-(4-pyridinyl)-;5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE;5,7-DiMethoxy-3-(pyridin-4-yl)quinoline dihydrochloride
CBNumber: CB2106454
Molecular Formula: C16H14N2O2
Formula Weight: 266.29
MOL File: 137206-97-4.mol

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5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Property

Boiling point:: 441.3±40.0 °C(Predicted)
Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble in DMSO (up to 1 mg/ml with warming) or in Water (up to 30 mg/ml).
form: solid
pka: 3.58±0.38(Predicted)
color: Yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 1222
Product name: DMPQ dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $149
Updated: 2021/12/16

Tocris

Product number: 1222
Product name: DMPQ dihydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $567
Updated: 2021/12/16

Usbiological

Product number: 255176
Product name: DMPQ dihydrochloride
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000096
Product name: DMPQ DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 10MG
Price: $665.81
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000096
Product name: DMPQ DIHYDROCHLORIDE
Purity: 95.00%
Packaging: 1MG
Price: $135.45
Updated: 2021/12/16

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5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable.

Uses

DMPQ dihydrochloride is a selective an a potent inhibitor of human platelet-derived growth factor receptor β (PDGFRβ).

Biological Activity

A potent and selective inhibitor of human vascular β -type platelet derived growth factor receptor tyrosine kinase (PDGFR β ) (IC 50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

References

1) Dolle et al. (1994), Effects of xanthine derivatives on lipolysis and on adenosine 3′,5′-monophosphate phosphodiesterase activity; J. Med. Chem., 37 2627

5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE Suppliers

CHINA 20 Europe 1 Germany 4 South Korea 1 United Kingdom 2 United States 6 Global 34

Synchem OHG

Tel: +49 5662 408730
Fax: +49 5662 4087320
Email: info@synchem.de
Country: Germany
ProdList: 4705
Advantage: 70

Service Chemical Inc.

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Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

BIOTREND GmbH

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Email: jaeger@biotrend.com
Country: Germany
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BIOTREND Chemicals AG

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Email: info@biotrend.ch
Country: Germany
ProdList: 1250
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137206-97-4, 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDERelated Search:

TYRPHOSTIN AG 879 SR9009 Sunitinib Malate SU 4312 5-METHOXYQUINOLINE 5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE

DMPQ DIHYDROCHLORIDE

5,7-DIMETHOXY-3-(4-PYRIDINYL)QUINOLINE DIHYDROCHLORIDE

DMPQ2HCl

Quinoline, 5,7-dimethoxy-3-(4-pyridinyl)-

5,7-dimethoxy-3-(4-pyridinyl)quinoline

5,7-DiMethoxy-3-(pyridin-4-yl)quinoline dihydrochloride

5,7-dimethoxy-3-pyridin-4-ylquinoline

DPMQ

137206-97-4

C16H14N2O22HCl

Protein Kinase