Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)

Product Name: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)
CAS No.: 386715-33-9
Chemical Name: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)
Synonyms: 2-(trifluoromethyl)-5-chloromethyl pyridine;Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)-;5-(Chloromethyl)-2-(trifluoromethyl)pyridine97%;Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI);5-Chloromethyl-2-(trifluoromethyl)pyridine, CAS 386715-33-9
CBNumber: CB21066296
Molecular Formula: C7H5ClF3N
Formula Weight: 195.57
MOL File: 386715-33-9.mol

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Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) Property

Boiling point:: 110°C/19mm
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Colorless to light yellow Solid-liquid mixture
InChI: InChI=1S/C7H5ClF3N/c8-3-5-1-2-6(12-4-5)7(9,10)11/h1-2,4H,3H2
InChIKey: PRPAYPBERKUDKO-UHFFFAOYSA-N
SMILES: C1(C(F)(F)F)=NC=C(CCl)C=C1

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Safety

RIDADR: 3265
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C588000
Product name: 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 006828
Product name: 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 006828
Product name: 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
Packaging: 1g
Price: $74
Updated: 2021/12/16

AK Scientific

Product number: 2217AE
Product name: 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
Packaging: 1g
Price: $151
Updated: 2021/12/16

Apolloscientific

Product number: PC7749
Product name: 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
Purity: 97%
Packaging: 5g
Price: $190
Updated: 2021/12/16

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Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) Chemical Properties,Usage,Production

Synthesis

386704-04-7

386715-33-9

General procedure for the synthesis of 5-chloromethyl-2-trifluoromethylpyridine from 6-trifluoromethyl-3-pyridine methanol: At room temperature and under nitrogen protection, [6-(trifluoromethyl)pyridin-3-yl]methanol (4.41 g, 24.9 mmol) was dissolved in anhydrous dichloromethane (82.5 ml) and triethylamine (4.2 ml, 30.1 mmol) and 4-dimethylamino pyridine (21.5 mg, 0.176 mmol). The reaction mixture was cooled to 0 °C, methanesulfonyl chloride (3.0 ml, 38.8 mmol) was added slowly dropwise and stirred at 0 °C for 1 h. The mixture was gradually warmed up to room temperature and continued to be stirred for 22 h. After the reaction was completed, the reaction was carried out at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent ratio of hexane:ethyl acetate=9:1→1:1 to afford 5-(chloromethyl)-2-trifluoromethylpyridine. The yield was 3.99 g, 84%, as yellow liquid.

References

[1] Patent: JP2017/178911, 2017, A. Location in patent: Paragraph 0133; 0134
[2] Patent: US2013/131036, 2013, A1. Location in patent: Paragraph 1574; 1575
[3] Patent: WO2013/62966, 2013, A2. Location in patent: Paragraph 101; 102
[4] Patent: US2014/107340, 2014, A1. Location in patent: Paragraph 0116
[5] Organic Letters, 2017, vol. 19, # 14, p. 3895 - 3898

Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) Suppliers

China 117 Europe 1 India 3 United Kingdom 3 United States 7 Global 131

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View Lastest Price from Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) 386715-33-9
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2019-12-27

Career Henan Chemical Co

Product: Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI) 386715-33-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 500kg
Release date: 2018-08-19

386715-33-9, Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)Related Search:

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Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)- (9CI)

2-(trifluoromethyl)-5-chloromethyl pyridine

5-(Chloromethyl)-2-(trifluoromethyl)pyridine97%

Pyridine, 5-(chloromethyl)-2-(trifluoromethyl)-

5-Chloromethyl-2-(trifluoromethyl)pyridine, CAS 386715-33-9

386715-33-9

HALOMETYL