dido

Product Name: dido
CAS No.: 69839-83-4
Chemical Name: dido
Synonyms: dido;Didox;NSC-324360;Didox, NSC-324360;Didox Exclusive;Didox, 10 mM in DMSO;4-Trihydroxybenzamide;N,3,4-trihydroxybenzamide;Benzamide, N,3,4-trihydroxy-;3,4-dihydroxybenzohydroxamic acid
CBNumber: CB21073551
Molecular Formula: C7H7NO4
Formula Weight: 169.13
MOL File: 69839-83-4.mol

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dido Property

Melting point:: 207 °C
Density: 1.571±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);354.76(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);118.25(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);118.25(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);59.13(Max Conc. mM)
form: A crystalline solid
pka: 8.16±0.20(Predicted)
color: Light yellow to khaki
InChI: InChI=1S/C7H7NO4/c9-5-2-1-4(3-6(5)10)7(11)8-12/h1-3,9-10,12H,(H,8,11)
InChIKey: QJMCKEPOKRERLN-UHFFFAOYSA-N
SMILES: C(NO)(=O)C1=CC=C(O)C(O)=C1

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Safety

Toxicity: LD10 unreported in mouse: 643mg/kg

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10009081
Product name: Didox
Purity: ≥98%
Packaging: 1mg
Price: $18
Updated: 2024/03/01

Cayman Chemical

Product number: 10009081
Product name: Didox
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10009081
Product name: Didox
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

Cayman Chemical

Product number: 10009081
Product name: Didox
Purity: ≥98%
Packaging: 50mg
Price: $553
Updated: 2024/03/01

TRC

Product number: D494623
Product name: Didox
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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dido Chemical Properties,Usage,Production

Description

Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants. Didox is a simple, synthetic antioxidant that has been found to reduce the levels of oxidative injury markers in the brains of HIV patients with dementia. It also increases the radiosensitivity of cancer cells by inhibition of ribonucleotide reductase, resulting in a reduction of bcl-2 mediated resistance to apoptosis.

Uses

Didox is a synthetic antioxidant that reduces oxidative injury levels.

Definition

ChEBI: N-3,4-tridhydroxybenzamide is a member of benzoic acids.

in vivo

Once engraftment is established by bioluminescent imaging, the animals receive daily administrations of Didox at 425 mg/kg via IP injection over 5 days. Didox (NSC-324360) treatment significantly reduces leukemic burden compared to vehicle treated controls (p=0.0026 and p=0.0342). More importantly, Didox (NSC-324360) provides a significant survival benefit (p<0.0001 and p=0.0094)^[2].

References

[1] J TURCHAN. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants.[J]. Neurology, 2003, 60 2: 307-314. DOI: 10.1212/01.wnl.0000042048.85204.3d
[2] MOHAMMED S INAYAT. Didox (a novel ribonucleotide reductase inhibitor) overcomes Bcl-2 mediated radiation resistance in prostate cancer cell line PC-3.[J]. Cancer Biology & Therapy, 2002, 1 5: 539-545. DOI: 10.4161/cbt.1.5.174

dido Preparation Products And Raw materials

Raw materials

Preparation Products

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dido Suppliers

China 96 Germany 1 India 1 United States 11 Global 109

Absin Bioscience Inc.

Tel: 13761418683
Email: zhouzz@univ-bio.com
Country: China
ProdList: 12050
Advantage: 58

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
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D&C Chemicals

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Suzhou Crst Pharmatech Co., Ltd.

Tel: 0512-62910395 17751098781
Fax: 0512-62910396
Email: sales@crstpharma.com
Country: China
ProdList: 499
Advantage: 58

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View Lastest Price from dido manufacturers

Career Henan Chemica Co

Product: dido 69839-83-4
Price: US $1.00/g
Min. Order: 1g
Purity: Min98% HPLC/GC
Supply Ability: g/kg/ton Coreychem-Nicole
Release date: 2020-11-06

69839-83-4, didoRelated Search:

2-HYDROXYACETOPHENONE Sodium iodide Sodium chlorate 3,4-diethoxy-N-hydroxybenzamide N-hydroxy-1,3-benzodioxole-5-carboxamide N-hydroxy-3,4-dimethoxybenzamide N-hydroxy-3,4,5-trimethoxybenzamide N,3,4-TRIMETHOXY-N-METHYLBENZAMIDE 4-BUTOXY-N-HYDROXY-3-METHOXY-BENZAMIDE dido

Didox Exclusive

N,3,4-trihydroxybenzamide

Didox, NSC-324360

dido

3,4-dihydroxybenzohydroxamic acid

Didox

4-Trihydroxybenzamide

NSC-324360

Benzamide, N,3,4-trihydroxy-

N,3,4-Trihydroxybenzamide[N,3,4-Trihydroxybenzamide

Didox, 10 mM in DMSO

69839-83-4