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Sulfacytine

Product Name
Sulfacytine
CAS No.
17784-12-2
Chemical Name
Sulfacytine
Synonyms
Cl 636;CI-636;Renoquid;Nsc356717;Sulfacitinum;N-Sulfanilyl-L-ethylcytosine;1-Ethyl-N-sulfanilylcytosine;4-amino-N-(1-ethyl-2-oxopyrimidin-4-yl)benzenesulfonamide;N(Sup1)-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamide;4-amino-N-(1-ethyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzenesulfonamide
CBNumber
CB21074699
Molecular Formula
C12H14N4O3S
Formula Weight
294.33
MOL File
17784-12-2.mol
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Sulfacytine Property

Melting point:
166.5-168°; mp 104°
Boiling point:
496.8±47.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
pka
6.9(at 25℃)
form 
Solid
color 
White to off-white
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Safety

Hazardous Substances Data
17784-12-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
S699340
Product name
Sulfacytine
Packaging
1g
Price
$1230
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004261
Product name
SULFACYTINE
Purity
95.00%
Packaging
100G
Price
$3698.89
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004261
Product name
SULFACYTINE
Purity
95.00%
Packaging
500G
Price
$8064.79
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004261
Product name
SULFACYTINE
Purity
95.00%
Packaging
1KG
Price
$11703.04
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48774
Product name
Sulfacytine
Packaging
100mg
Price
$640
Updated
2021/12/16
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Sulfacytine Chemical Properties,Usage,Production

Originator

Renoquid,Glenwood,US,1975

Uses

Antibacterial.

Uses

Sulfacytine is a soluble short-acting sulfonamide. Sulfacytine is used as an oral antibiotic.

Definition

ChEBI: Sulfacytine is a member of benzenes and a sulfonamide.

Manufacturing Process

The N-(N-acetylsulfanilyl)-1-ethylcytosine used as a starting material is prepared as follows: To a solution of 333 grams of 3-(ethylamino)propionitrile in 1,697.3 ml of 2 N hydrochloric acid is added 275 grams of potassium cyanate, the resulting solution is concentrated under reduced pressure to a syrup, and the syrup is heated at 90° to 100°C for 6 hours and then evaporated to dryness at 90° to 100°C under reduced pressure. The residue is extracted with 1,600 ml of hot absolute ethanol, and the extract is concentrated to 500 ml and chilled. The crystalline 1-(2-cyanoethyl)-1- ethylurea obtained is isolated, washed with cold absolute ethanol, and dried, melting point 88° to 91°C. This intermediate (58.7 grams) is added to a solution of 11.5 grams of sodium in 500 ml of methanol and the resulting solution is heated under reflux for 30 minutes. After cooling, the mixture, containing 1-ethyl-5,6-dihydrocytosine, is treated with a slight excess of gaseous hydrogen bromide and evaporated to dryness. The residue is extracted, first with 500 ml, then with 100 ml of hot isopropyl alcohol, the extracts are combined and chilled, and the crystalline 1-ethyl-5,6-dihydrocytosine hydrobromide obtained is isolated and dried, MP 167.5° to 169.5°C. This salt (88.8 grams) is dissolved in 200 ml of nitrobenzene at 174°C, 22.6 ml of bromine is added over a period of 8 minutes, and the mixture is kept at 170° to 175°C until hydrogen bromide evolution ceases (about 15 minutes). Upon cooling, there is obtained crude 1-ethylcytosine hydrobromide, which is isolated, washed with ether, and dried, MP 170° to 187°C.
This salt is heated at 90° to 100°C with 70 ml of N,N-dimethylformamide and 60 ml of piperidine, and the resulting solution is chilled to give 1- ethylcytosine, MP 238° to 243°C. A mixture of 10.5 grams of 1-ethylcytosine, 18.6 grams of N-acetylsulfanilyl chloride, and 50 ml of pyridine is stirred at room temperature for 2 days. The precipitated solid is removed by filtration, and the filtrate is evaporated at 60°C under reduced pressure to a syrup. The syrup is triturated with 0.25N hydrochloric acid, and the solid N-(N-acetylsulfanilyl)- 1-ethylcytosine obtained is isolated and dried. This solid is suitable for use without further purification.
A solution of 65 grams of N-(N-acetylsulfanilyl)-1-ethylcytosine in 380 ml of 2 N aqueous sodium hydroxide is heated under reflux for 1 hour. Upon cooling, the solution is treated with charcoal, purified by filtration, and acidified with acetic acid. The solid N-sulfanilyl-1-ethylcytosine that precipitates is isolated, washed with water, and dried, MP 166.5° to 168°C following successive crystallizations from butyl alcohol and from methanol.

brand name

Renoquid (Glenwood).

Therapeutic Function

Antibacterial

Sulfacytine Preparation Products And Raw materials

Raw materials

Preparation Products

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Sulfacytine Suppliers

Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24648
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4870
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9272
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38463
Advantage
58

17784-12-2, SulfacytineRelated Search:


  • 4-Amino-N-(1-ethyl-1,2-dihydro-2-oxopyrimidin-4-yl)benzenesulfonamide
  • CI-636
  • 1-Ethyl-N-sulfanilylcytosine
  • Benzenesulfonamide, 4-amino-N-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-
  • Cl 636
  • N(Sup1)-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamide
  • Nsc356717
  • N-Sulfanilyl-L-ethylcytosine
  • Renoquid
  • 4-amino-N-(1-ethyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzenesulfonamide
  • 4-amino-N-(1-ethyl-2-oxopyrimidin-4-yl)benzenesulfonamide
  • Sulfacitinum
  • 17784-12-2