1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
- Product Name
- 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
- CAS No.
- 76778-22-8
- Chemical Name
- 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
- Synonyms
- CS-1257;GBR 12935;GBR12935;GBR-12935;GBR 12935 mesylate;GBR-12935 free base;(DIPHENYLMETHOXY)GBR - 12935;1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl);1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)pi;1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine;1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine
- CBNumber
- CB21075414
- Molecular Formula
- C28H34N2O
- Formula Weight
- 414.58
- MOL File
- 76778-22-8.mol
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride Property
- Boiling point:
- 540.6±50.0 °C(Predicted)
- Density
- 1.067±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 7.55±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- B193930
- Product name
- 1-(2-(Benzhydryloxy)ethyl-4-(3-phenylpropyl)piperazine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FG65031
- Product name
- GBR 12935 mesylate
- Packaging
- 10mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- Y0450
- Product name
- 1-(2-Benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine
- Packaging
- 10mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- orb611503
- Product name
- GBR 12935
- Packaging
- 100mg
- Price
- $277.1
- Updated
- 2021/12/16
- Product number
- orb611503
- Product name
- GBR 12935
- Packaging
- 250mg
- Price
- $414.8
- Updated
- 2021/12/16
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride Chemical Properties,Usage,Production
Uses
GBR 12935 is a potent, and selective dopamine reuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 also prevents the d-Fenfluramine-induced head-twitch response in mice[1][2][3][4].
Definition
ChEBI: An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat stria al membranes).
Biological Activity
Potent and selective inhibitor of dopamine uptake (K D = 5.5 nM in rat striatal membranes).
in vivo
GBR 12935 (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections[3].
| Animal Model: | Adult male DBA/2J and C57BL/6J mice (22-30 g)[3] |
| Dosage: | 1.0, 3.2, 10, 32 mg/kg |
| Administration: | Repeat injection; for 7 days |
| Result: | Elevated locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice. No stereotypy was induced by an eighth day challenge of 10 mg/kg GBR 12935 in mice pretreated with seven dally injections of either 32 mg/kg cocaine or saline. |
References
[1] Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9. DOI:10.1016/s0006-2952(97)00172-x
[2] Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44. DOI:10.1016/s0014-2999(01)00785-3
[3] Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9. DOI:10.1016/0091-3057(94)90340-9
[4] Darmani NA. Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine, and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice. Pharmacol Biochem Behav. 1998 May;60(1):83-90. DOI:10.1016/s0091-3057(97)00548-0
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride manufacturers
- Product
- 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)pi 76778-22-8
- Price
- US $8.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03
- Product
- 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride 76778-22-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-02-17