ChemicalBook > CAS DataBase List > 4-Pyrimidinecarbonitrile, 2-amino- (9CI)

4-Pyrimidinecarbonitrile, 2-amino- (9CI)

Product Name
4-Pyrimidinecarbonitrile, 2-amino- (9CI)
CAS No.
36314-98-4
Chemical Name
4-Pyrimidinecarbonitrile, 2-amino- (9CI)
Synonyms
2-amipyrimidine-4-carbonitrile;2-Amino-4-pyrimidinecarbonitrile;2-aminopyrimidine-4-carbonitrile;4-Pyrimidinecarbonitrile,2-amino-;4-Pyrimidinecarbonitrile, 2-amino- (9CI);4-Pyrimidinecarbonitrile, 2-amino- (9CI) ISO 9001：2015 REACH
CBNumber
CB21081914
Molecular Formula
C5H4N4
Formula Weight
120.11
MOL File
36314-98-4.mol
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4-Pyrimidinecarbonitrile, 2-amino- (9CI) Property

Melting point:
222 °C (decomp)
Boiling point:
387.9±34.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
1.63±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A617115
Product name
2-Amino-4-pyrimidinecarbonitrile
Packaging
25mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA154292
Product name
2-Amino-4-cyanopyrimidine
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA154292
Product name
2-Amino-4-cyanopyrimidine
Packaging
100mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA154292
Product name
2-Amino-4-cyanopyrimidine
Packaging
250mg
Price
$125
Updated
2021/12/16
ChemScene
Product number
CS-W019700
Product name
2-Aminopyrimidine-4-carbonitrile
Packaging
1g
Price
$190
Updated
2021/12/16
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4-Pyrimidinecarbonitrile, 2-amino- (9CI) Chemical Properties,Usage,Production

Uses

2-Amino-4-pyrimidinecarbonitrile is a derivative of Pyrimidine (P997330), a heterocyclic organic molecule present in many pharmaceutical and naturally derived compounds.

Synthesis

557-21-1

815610-16-3

36314-98-4

General procedure for the synthesis of 2-amino-4-cyanopyrimidine from zinc cyanide and 2-amino-4-iodopyrimidine: a solution of N-methylpyrrolidone (NMP, 75 mL) containing 2-amino-4-iodopyrimidine (4.09 g, 18.5 mmol) was placed in a flask and purged with argon for 5 min to remove oxygen. Subsequently, zinc cyanide (2.28 g, 19.4 mmol) and tetrakis(triphenylphosphine)palladium(0) (1.71 g, 1.48 mmol) were added, and the reaction mixture was stirred at 80 °C for 2 hours. After completion of the reaction, the mixture was cooled to room temperature, ethyl acetate (EtOAc, 200 mL) and 30% ammonia (NH4OH, 200 mL) were added, and stirring was continued for 1 hour. The organic and aqueous layers were separated and the aqueous layer was extracted with ethyl acetate (4 x 200 mL). All organic layers were combined and concentrated under reduced pressure. Ether (Et2O, 30 mL) was added to the concentrate, the precipitate was collected by filtration and washed with ether to afford 2-amino-4-cyanopyrimidine (1.66 g, 13.8 mmol, 75% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.51 (d, J = 4.7 Hz, 1H), 7.31 (br.s, 2H), 7.08 (d, J = 4.7 Hz, 1H). Mass spectrum (ESI, cation mode) m/z: 121.1 ([M+H]+).

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 80, p. 364 - 382

4-Pyrimidinecarbonitrile, 2-amino- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Pyrimidinecarbonitrile, 2-amino- (9CI) Suppliers

China 68 Europe 1 Germany 1 India 1 United Kingdom 2 United States 8 Global 81
Pure Chemistry Scientific Inc.
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View Lastest Price from 4-Pyrimidinecarbonitrile, 2-amino- (9CI) manufacturers

Dideu Industries Group Limited
Product
4-Pyrimidinecarbonitrile, 2-amino- (9CI) 36314-98-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-14
Career Henan Chemical Co
Product
4-Pyrimidinecarbonitrile, 2-amino- (9CI) 36314-98-4
Price
US $5.00/KG
Min. Order
5KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-02

36314-98-4, 4-Pyrimidinecarbonitrile, 2-amino- (9CI)Related Search:

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