Amrubicin

ChemicalBook > CAS DataBase List > Amrubicin

Product Name: Amrubicin
CAS No.: 110267-81-7
Chemical Name: Amrubicin
Synonyms: CS-1168;Amrubicin;Amurubicin;(7S)-9β-Amino-9-acetyl-7β-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;(7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy--D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione;5,12-Naphthacenedione,9-acetyl-9-aMino-7-(2-deoxy-b-D-erythro-pentopyranosyl)oxy-7,8,9,10-tetrahydro-6,11-dihydroxy-,(7S,9S)-;(7S,9S)-9-Amino-9-acetyl-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione;(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione;5,12-Naphthacenedione, 9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-, (7S,9S)-
CBNumber: CB21091573
Molecular Formula: C25H25NO9
Formula Weight: 483.47
MOL File: 110267-81-7.mol

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Amrubicin Property

Melting point:: 172-1740C
alpha: D20 +119° (c = 0.02 in CHCl3)
Boiling point:: 717.8±60.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: >16.45mg/mL in DMSO
form: Powder
pka: 7.83±0.60(Predicted)
color: Pink to red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A635200
Product name: Amrubicin
Packaging: 1mg
Price: $300
Updated: 2021/12/16

ApexBio Technology

Product number: A8227
Product name: (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione
Packaging: Evaluation Sample
Price: $28
Updated: 2021/12/16

ApexBio Technology

Product number: A8227
Product name: (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione
Packaging: 1mg
Price: $150
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0000383
Product name: AMRUBICIN
Purity: 95.00%
Packaging: 2MG
Price: $325
Updated: 2021/12/16

ApexBio Technology

Product number: A8227
Product name: (7S,9S)-9-acetyl-9-amino-7-[(2S,4S,5R)-4,5-dihydroxyoxan-2-yl]oxy-6,11-dihydroxy-8,10-dihydro-7H-tetracene-5,12-dione
Packaging: 5mg
Price: $450
Updated: 2021/12/16

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Amrubicin Chemical Properties,Usage,Production

Description

Amrubicin is an active agent for the treatment of small-cell lung cancer (SCLC). It is a type of anthracycline analog. Anthracycline derivatives such as doxorubicin (DXR), daunorubicin (DNR) and epirubicin have been widely used for a variety of carcinomas in the clinical context. Amrubicin is structurally distinguishable from other anthracyclines by the amino group at the 9-position and its unique sugar moiety. In April 2002, Amrubicin was approved in Japan for the treatment of non-small cell lung cancer and small cell lung cancer.

Uses

Synthetic anthracycline antibiotic; inhibits DNA topoisomerase II. Antineoplastic. Amrubicin is used to treat small-cell lung cancer (SCLC).

Definition

ChEBI: Amrubicin is a synthetic anthracycline antibiotic with molecular formula C25H25NO9. A specific inhibitor of topoisomerase II, it is used (particularly as the hydrochloride salt) in the treatment of cancer, especially lung cancer, where it is a prodrug for the active metabolite, ambrucinol. It has a role as a topoisomerase II inhibitor, an antineoplastic agent and a prodrug. It is a quinone, a member of tetracenes, a methyl ketone, an anthracycline antibiotic and a primary amino compound.

target

Topoisomerase II

Mode of action

Amrubicin (AMR), a third-generation anthracycline and potent topoisomerase II inhibitor that intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and RNA and protein synthesis, followed by cell growth inhibition and cell death. Amrubicin is structurally distinguishable from other anthracyclines by the amino group at the 9-position and its unique sugar moiety. This agent has demonstrated a higher level of anti-tumor activity than conventional anthracycline drugs without exhibiting any indication of the cumulative cardiac toxicity common to this class of compounds.

Amrubicin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Amrubicin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Amrubicin 110267-81-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

Career Henan Chemical Co

Product: AMRUBICIN 110267-81-7
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

110267-81-7, AmrubicinRelated Search:

Dexrazoxane 6,11-DIHYDROXY-5,12-NAPHTHACENEDIONE 2-(4-BIPHENYL)ETHYLAMINE 3,4-DIMETHYLPHENETHYLAMINE 1,4-DIHYDROXY-2,3-DIMETHYLANTHRAQUINONE 1,2,3,4-TETRAHYDRO-1,5-NAPHTHALENEDIOL 2-(HYDROXYMETHYL)ANTHRAQUINONE 2,5-DIMETHYLPHENETHYLAMINE Benzeneethanamine, -alpha--ethyl-3-methyl- 2-Ethyl anthraquinone 1-(4-METHYL-PHENYL)-2-BUTANAMINE 3-(2,4-DIMETHYL-PHENYL)-PROPIONALDEHYDE 1-(1-HYDROXY-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-ETHANONE Amrubicin

(7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy--D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione

(7S)-9β-Amino-9-acetyl-7β-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione

(7S,9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranosyloxy)-6,11-dihydroxy-5,7,8,9,10,12-hexahydro-5,12-naphthacenedione

CS-1168

(7S,9S)-9-Amino-9-acetyl-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxynaphthacene-5,12-dione

Amurubicin

5,12-Naphthacenedione,9-acetyl-9-aMino-7-(2-deoxy-b-D-erythro-pentopyranosyl)oxy-7,8,9,10-tetrahydro-6,11-dihydroxy-,(7S,9S)-

5,12-Naphthacenedione, 9-acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-, (7S,9S)-

Amrubicin

110267-81-7

C25H25NO9

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