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Dexrazoxane

Product Name
Dexrazoxane
CAS No.
24584-09-6
Chemical Name
Dexrazoxane
Synonyms
adr529;cardioxane;DEXRAZOXANE;(S)-ICRF-187;DEXTRAZOXANE;DEXTRORAZOXANE;Dexrazoxane>(+)-dexrazoxane;Dexrazoxane, >=99%;ICRF-187;NSC-169780
CBNumber
CB2251448
Molecular Formula
C11H16N4O4
Formula Weight
268.27
MOL File
24584-09-6.mol
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Dexrazoxane Property

Melting point:
194-196°C
alpha 
D +11.35° (c = 5 in DMF)
Boiling point:
531.5±50.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
pka
2.1(at 25℃)
color 
white to off-white
Merck 
14,8123
InChIKey
BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference
24584-09-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
TL6390000
Hazardous Substances Data
24584-09-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
05587
Product name
Dexrazoxane
Purity
analytical standard
Packaging
25mg
Price
$75.3
Updated
2021/03/22
Sigma-Aldrich
Product number
D1446
Product name
Dexrazoxane
Purity
≥95% (HPLC)
Packaging
5mg
Price
$88.2
Updated
2021/03/22
TCI Chemical
Product number
D4227
Product name
Dexrazoxane
Purity
>98.0%(T)
Packaging
100mg
Price
$58
Updated
2021/03/22
Cayman Chemical
Product number
14632
Product name
Dexrazoxane
Purity
≥98%
Packaging
10mg
Price
$67
Updated
2021/03/22
Cayman Chemical
Product number
14632
Product name
Dexrazoxane
Purity
≥98%
Packaging
5mg
Price
$48
Updated
2021/03/22
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Dexrazoxane Chemical Properties,Usage,Production

Description

Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.

Originator

Imperial Cancer Research Fund (United Kingdom)

Uses

Cardioprotectant.

brand name

Zinecard (Pharmacia & Upjohn);Cardioxane.

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Veterinary Drugs and Treatments

Dexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.

Dexrazoxane Preparation Products And Raw materials

Raw materials

Preparation Products

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Dexrazoxane Suppliers

Liaoning bomei pharmaceutical technology co. LTD.
Tel
24-24524889
Fax
+86-24-24524889
Email
sales@biosunpharm.com
Country
China
ProdList
46
Advantage
58
Porton Fine Chemicals
Tel
023-86083200-6830
Fax
023860832006830
Email
yan.shangguan@porton.cn;
Country
China
ProdList
112
Advantage
58
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876-
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1828
Advantage
55
Jinan chenghui-shuangda chemical co.,ltd.
Tel
Email
mahaiyan1123@126.com
Country
China
ProdList
111
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2213
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
9917
Advantage
62
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View Lastest Price from Dexrazoxane manufacturers

Jinan Ande Pharmaceutical Co.,Ltd.
Product
Dexrazoxane 24584-09-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50
Release date
2021-08-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dexrazoxane 24584-09-6
Price
US $0.00/Kg/Bag
Min. Order
1g
Purity
98%-102%
Supply Ability
10KGS
Release date
2021-07-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Dexrazoxane 24584-09-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

24584-09-6, DexrazoxaneRelated Search:


  • DEXRAZOXANE
  • (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
  • 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4
  • 4’-propylenedi-6-piperazinedion(+)-4
  • adr529
  • cardioxane
  • DEXTRAZOXANE
  • DEXTRORAZOXANE
  • (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
  • (S)-ICRF-187
  • [S,(+)]-4,4'-Propylenebis(2,6-piperazinedione)
  • 4,4'-[(S)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione)
  • 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride
  • 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
  • (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
  • Dexrazoxane ((S)-Razoxane)
  • 2,6-Piperazinedione,4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-
  • (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione
  • (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
  • Dexrazoxane (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione)
  • Dexrazoxane, >=99%
  • Ca rdioxane、Dextrazoxane、Eucardion、Zinecard
  • ICRF-187;NSC-169780
  • Dexrazoxane (ICRF-187
  • Dexrazoxane&gt
  • (+)-dexrazoxane
  • Dexrazoxane Impurity
  • 24584-09-6
  • C11H16N4O4
  • API
  • Chelating Agent