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Dexrazoxane

Product Name
Dexrazoxane
CAS No.
24584-09-6
Chemical Name
Dexrazoxane
Synonyms
adr529;cardioxane;DEXRAZOXANE;(S)-ICRF-187;DEXTRAZOXANE;DEXTRORAZOXANE;Dexrazoxane>Right razoxane;(+)-dexrazoxane;Dexrazoxane, >=99%
CBNumber
CB2251448
Molecular Formula
C11H16N4O4
Formula Weight
268.27
MOL File
24584-09-6.mol
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Dexrazoxane Property

Melting point:
194-196°C
alpha 
D +11.35° (c = 5 in DMF)
Boiling point:
531.5±50.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
powder
pka
2.1(at 25℃)
color 
white to off-white
Merck 
14,8123
InChIKey
BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference
24584-09-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
TL6390000
HS Code 
2933.59.9500
Hazardous Substances Data
24584-09-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1446
Product name
Dexrazoxane
Purity
≥95% (HPLC)
Packaging
5mg
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
05587
Product name
Dexrazoxane
Purity
analytical standard
Packaging
25mg
Price
$94.4
Updated
2024/03/01
TCI Chemical
Product number
D4227
Product name
Dexrazoxane
Purity
>98.0%(T)
Packaging
100mg
Price
$67
Updated
2024/03/01
Cayman Chemical
Product number
14632
Product name
Dexrazoxane
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14632
Product name
Dexrazoxane
Purity
≥98%
Packaging
10mg
Price
$48
Updated
2024/03/01
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Dexrazoxane Chemical Properties,Usage,Production

Description

Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.

Originator

Imperial Cancer Research Fund (United Kingdom)

Uses

Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Uses

Dexrazoxane has been used in chromatin remodelling experiments.

Uses

Cardioprotectant.

Definition

ChEBI: (+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.

brand name

Zinecard (Pharmacia & Upjohn);Cardioxane.

General Description

Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Biochem/physiol Actions

Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Clinical Use

Cardioxane? Prevention of cardiotoxicity in patients receiving doxorubicin or epirubicin for breast cancer Savene? : Treatment of extravasation caused by anthracyclines

Veterinary Drugs and Treatments

Dexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.

Drug interactions

Potentially hazardous interactions with other drugs
Antiepileptics: may reduce absorption of fosphenytoin and phenytoin.
Ciclosporin: increased risk of immunosuppression with risk of lymphoproliferative disease.
Tacrolimus: increased risk of immunosuppression with risk of lymphoproliferative disease.
Vaccines: risk of generalised infections with live vaccines - avoid.

Metabolism

Dexrazoxane is hydrolysed by the enzyme dihydropyrimidine amidohydrolase in the liver and kidney to active metabolites that are capable of binding to metal ions.
It is excreted unchanged via the kidney

Dexrazoxane Preparation Products And Raw materials

Raw materials

Preparation Products

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Dexrazoxane Suppliers

Liaoning bomei pharmaceutical technology co. LTD.
Tel
24-24524889 18640309171
Fax
+86-24-24524889
Email
236415745@qq.com
Country
China
ProdList
47
Advantage
58
Jinan chenghui-shuangda chemical co.,ltd.
Tel
13256107535
Email
mahaiyan1123@126.com
Country
China
ProdList
117
Advantage
58
Porton Pharma Solutions Ltd.
Tel
23-86083200-6540
Fax
023860832006830
Email
jia.chen@portonpharma.com
Country
China
ProdList
56
Advantage
58
Chongqing Bioland Pharmaceuticat Ltd.
Tel
023-68509220
Email
sales1@biolandpharm.com
Country
China
ProdList
67
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
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View Lastest Price from Dexrazoxane manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Dexrazoxane 24584-09-6
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dexrazoxane 24584-09-6
Price
US $0.00/Kg/Bag
Min. Order
1g
Purity
98%-102%
Supply Ability
10KGS
Release date
2021-07-16
Hangzhou Hyper Chemicals Limited
Product
Dexrazoxane 24584-09-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%, USP
Supply Ability
5,000KG
Release date
2024-08-30

24584-09-6, DexrazoxaneRelated Search:


  • DEXRAZOXANE
  • (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione
  • 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4
  • 4’-propylenedi-6-piperazinedion(+)-4
  • adr529
  • cardioxane
  • DEXTRAZOXANE
  • DEXTRORAZOXANE
  • (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane
  • (S)-ICRF-187
  • [S,(+)]-4,4'-Propylenebis(2,6-piperazinedione)
  • 4,4'-[(S)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione)
  • 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride
  • 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
  • (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
  • Dexrazoxane ((S)-Razoxane)
  • 2,6-Piperazinedione,4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-
  • (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione
  • (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
  • Dexrazoxane (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione)
  • Dexrazoxane, >=99%
  • Ca rdioxane、Dextrazoxane、Eucardion、Zinecard
  • ICRF-187;NSC-169780
  • Dexrazoxane (ICRF-187
  • Dexrazoxane&gt
  • (+)-dexrazoxane
  • Dexrazoxane Impurity
  • Dexrazoxane (NSC-169780)
  • Dextrozosan. - Dextropropimide
  • Right razoxane
  • Dexrazoxane 24584-09-6
  • 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione
  • 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-
  • 24584-09-6
  • C11H16N4O4
  • API
  • Chelating Agent
  • 24584-09-6