ICRF-186
- Product Name
- ICRF-186
- CAS No.
- 24613-06-7
- Chemical Name
- ICRF-186
- Synonyms
- ICRF-186;NSC-169779;NSC 169779;(R)-Razoxane;Razoxane, (R)-;R- Dexrazoxane;Dexrazoxane Impurity 8;Dexrazoxane Impurity 9;Carvedilol Impurity 36;(R)-Razoxane (Levrazoxane)
- CBNumber
- CB82169369
- Molecular Formula
- C11H16N4O4
- Formula Weight
- 268.27
- MOL File
- 24613-06-7.mol
ICRF-186 Property
- Boiling point:
- 531.5±50.0 °C(Predicted)
- Density
- 1.333±0.06 g/cm3(Predicted)
- pka
- 11.00±0.20(Predicted)
- InChI
- InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m1/s1
- InChIKey
- BMKDZUISNHGIBY-SSDOTTSWSA-N
- SMILES
- [C@@H](N1CC(=O)NC(=O)C1)(C)CN1CC(=O)NC(=O)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
ICRF-186 Chemical Properties,Usage,Production
Uses
(R)-Levrazoxane ((R)-ICRF 186) is enzymatically hydrolysed to one-ring open intermediates by dihydropyrimidine amidohydrolase (DPHase), which is present in the liver and kidney. The radiosensitizing efficiency of (R)-Levrazoxane towards EMT6 mouse mammary tumour cells is greater than that of Dexrazoxane (HY-B0581). (R)-Levrazoxane is promising for research of liver and kidney related diseases[1].
References
[1] Hasinoff BB, et al. Metabolism of the cardioprotective agents dexrazoxane (ICRF-187) and levrazoxane (ICRF-186) by the isolated hepatocyte. Xenobiotica. 1994 Oct;24(10):977-87. DOI:10.3109/00498259409043295
ICRF-186 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ICRF-186 manufacturers
- Product
- Dexrazoxane Impurity 24613-06-7
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98
- Supply Ability
- 10000000
- Release date
- 2024-12-10