2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID
- Product Name
- 2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID
- CAS No.
- 1003709-47-4
- Chemical Name
- 2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID
- Synonyms
- 2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID;Benzoic acid, 2-bromo-4-fluoro-6-methyl-
- CBNumber
- CB21091715
- Molecular Formula
- C8H6BrFO2
- Formula Weight
- 233.03
- MOL File
- Mol file
2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID Property
- Boiling point:
- 306.6±42.0 °C(Predicted)
- Density
- 1.680±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.53±0.37(Predicted)
- Appearance
- Light brown to off-white Solid
- InChI
- InChI=1S/C8H6BrFO2/c1-4-2-5(10)3-6(9)7(4)8(11)12/h2-3H,1H3,(H,11,12)
- InChIKey
- VOFBSAUUUDKWGR-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=C(C)C=C(F)C=C1Br
N-Bromosuccinimide Price
- Product number
- X4312
- Product name
- 2-Bromo-4-fluoro-6-methylbenzoicacid
- Packaging
- 250mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- X4312
- Product name
- 2-Bromo-4-fluoro-6-methylbenzoicacid
- Packaging
- 1g
- Price
- $246
- Updated
- 2021/12/16
- Product number
- HCH0065957
- Product name
- 2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.06
- Updated
- 2021/12/16
- Product number
- CM159007
- Product name
- 2-Bromo-4-fluoro-6-methylbenzoicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $552
- Updated
- 2021/12/16
- Product number
- 1003709474
- Product name
- 2-Bromo-4-fluoro-6-methylbenzoicacid
- Packaging
- 5g
- Price
- $561.13
- Updated
- 2021/12/16
2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID Chemical Properties,Usage,Production
Synthesis
1262396-02-0
1003709-47-4
The general procedure for the synthesis of 2-bromo-4-fluoro-6-methylbenzoic acid from the compound (CAS: 1262396-02-0) was as follows: 2-bromo-4-fluoro-6-methylbenzamide (0.9 g, 3.9 mmol) was dissolved in 75% aqueous sulfuric acid (4 mL) and heated to 80 °C. Sodium nitrite (0.5 g, 7.2 mmol) was added slowly over a period of 1 h. Continuous generation of nitrogen dioxide gas was observed during the reaction. Upon completion of the reaction, the mixture was cooled to 20 °C and diluted by adding cold water (15 mL). The product was extracted several times with ethyl acetate (6 x 2 mL). The organic phases were combined, washed sequentially with water (4 × 2 mL) and brine (2 × 2 mL), dried over anhydrous sodium sulfate, filtered and concentrated to give 0.879 g of pure 2-bromo-4-fluoro-6-methylbenzoic acid in 97% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (300 MHz, DMSO-d6 + CCl4), and the data were consistent with the expected structure.
References
[1] Patent: WO2011/6803, 2011, A1. Location in patent: Page/Page column 35
[2] Patent: WO2014/64149, 2014, A1. Location in patent: Page/Page column 27; 28
2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID manufacturers
- Product
- 2-BROMO-4-FLUORO-6-METHYLBENZOIC ACID 1003709-47-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20