8-CHLORO-[1,7]NAPHTHYRIDINE
- Product Name
- 8-CHLORO-[1,7]NAPHTHYRIDINE
- CAS No.
- 13058-77-0
- Chemical Name
- 8-CHLORO-[1,7]NAPHTHYRIDINE
- Synonyms
- 8-Chloro-1,7phthyridine;8-CHLORO-[1,7]NAPHTHYRIDINE;1,7-Naphthyridine, 8-chloro-;8-chloro-1,7-naphthyridine - [C82253]
- CBNumber
- CB2109758
- Molecular Formula
- C8H5ClN2
- Formula Weight
- 164.59
- MOL File
- 13058-77-0.mol
8-CHLORO-[1,7]NAPHTHYRIDINE Property
- Boiling point:
- 307.9±22.0 °C(Predicted)
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- 1.54±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C383720
- Product name
- 8-Chloro-1,7-Naphthyridine
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- C383720
- Product name
- 8-Chloro-1,7-Naphthyridine
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 190200
- Product name
- 8-Chloro-1,7-naphthyridine
- Packaging
- 1g
- Price
- $676
- Updated
- 2021/12/16
- Product number
- HCH0043891
- Product name
- 8-CHLORO-[1,7]NAPHTHYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1237.01
- Updated
- 2021/12/16
- Product number
- 5584AA
- Product name
- 8-Chloro-1,7-naphthyridine
- Packaging
- 5g
- Price
- $1411
- Updated
- 2021/12/16
8-CHLORO-[1,7]NAPHTHYRIDINE Chemical Properties,Usage,Production
Synthesis
67967-11-7
13058-77-0
General procedure for the synthesis of 8-chloro-1,7-naphthyridine from 1,7-naphthyridin-8(7H)-one: 1,7-naphthyridin-8(7H)-one (2.0 g, 13.7 mmol) was dissolved in phosphorus triclopyr (20 mL) and heated and refluxed at 100 °C for 16 h. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The residue was neutralized by adding saturated sodium bicarbonate solution (20 mL) and subsequently extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, washed with saturated saline (25 mL) and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the resulting crude product was purified by silica gel column chromatography to afford 8-chloro-1,7-naphthyridine (1.4 g, 62% yield) using dichloromethane/methanol (98:2 to 95:5, v/v) as eluent. Mass spectrum (EI) m/z: 165.3 ([M+H]+); 1H NMR (400 MHz, DMSO-d6) δ: 7.64 (d, J = 6.0 Hz, 1H), 7.70 (dd, J = 4.0, 8.4 Hz, 1H), 8.22 (dd, J = 1.6, 8.4 Hz, 1H), 8.40 (d, J = 6.0 Hz. 1H), 9.15 (dd, J = 1.6, 4.0 Hz, 1H).
References
[1] Patent: WO2017/14323, 2017, A1. Location in patent: Paragraph 0280
8-CHLORO-[1,7]NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-CHLORO-[1,7]NAPHTHYRIDINE manufacturers
- Product
- 8-CHLORO-[1,7]NAPHTHYRIDINE 13058-77-0
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-30