8-bromo-1,2,3,4-tetrahydroisoquinoline
Uses- Product Name
- 8-bromo-1,2,3,4-tetrahydroisoquinoline
- CAS No.
- 75416-51-2
- Chemical Name
- 8-bromo-1,2,3,4-tetrahydroisoquinoline
- Synonyms
- 8-BroMo-1,2,3,4-tetrahydroisoquinline;8-bromo-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 8-broMo-1,2,3,4-tetrahydro-;Isoquinoline, 8-bromo-1,2,3,4-tetrahydro-, hydrochloride (1:1)
- CBNumber
- CB8547345
- Molecular Formula
- C9H10BrN
- Formula Weight
- 212.09
- MOL File
- 75416-51-2.mol
8-bromo-1,2,3,4-tetrahydroisoquinoline Property
- Boiling point:
- 294℃
- Density
- 1.428
- Flash point:
- 132℃
- storage temp.
- 2-8°C(protect from light)
- pka
- 8.88±0.20(Predicted)
- Appearance
- Off-white to yellow Solid-liquid mixture
- InChI
- InChI=1S/C9H10BrN/c10-9-3-1-2-7-4-5-11-6-8(7)9/h1-3,11H,4-6H2
- InChIKey
- KHWGHUZYXQPIKA-UHFFFAOYSA-N
- SMILES
- C1C2=C(C=CC=C2Br)CCN1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- P000475799
- Product name
- 8-Bromo-1,2,3,4-tetrahydroisoquinoline
- Purity
- 97%
- Packaging
- 100mg
- Price
- $24
- Updated
- 2021/12/16
- Product number
- P000475799
- Product name
- 8-Bromo-1,2,3,4-tetrahydroisoquinoline
- Purity
- 97%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FB141672
- Product name
- 8-Bromo-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- P000475799
- Product name
- 8-Bromo-1,2,3,4-tetrahydroisoquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 1719AC
- Product name
- 8-Bromo-1,2,3,4-tetrahydroisoquinoline
- Packaging
- 100mg
- Price
- $96
- Updated
- 2021/12/16
8-bromo-1,2,3,4-tetrahydroisoquinoline Chemical Properties,Usage,Production
Uses
8-Bromo-1,2,3,4-tetrahydroisoquinoline is a useful intermediate for organic synthesis.
Uses
8-Bromo-1,2,3,4-tetrahydroisoquinoline is a useful intermediate for organic synthesis.
Synthesis
252331-63-8
726136-49-8
226942-29-6
75416-51-2
To a solvent mixture of methanol (20 mL) and saturated aqueous sodium carbonate (20 mL) was added 1-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroacetophenone mixed with 1-(8-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethanone (3 g, 9.7 mmol). The reaction mixture was heated to reflux overnight and subsequently concentrated. The residue was extracted with dichloromethane, the organic layers were combined, washed sequentially with water and saturated sodium chloride solution, dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The crude product was purified by silica gel column chromatography (230-400 mesh) with 0-2% methanol/chloroform solution as eluent to give 8-bromo-1,2,3,4-tetrahydroisoquinoline (first fraction, colorless viscous oil, 0.45 g, 22% yield) and 6-bromo-1,2,3,4-tetrahydroisoquinoline (second fraction, white solid, 1.0 g, 48% yield) sequentially. Mass spectrum (MS) m/z: 211.9 [M + H]+.
References
[1] Patent: WO2008/76954, 2008, A2. Location in patent: Page/Page column 50
[2] Patent: US2008/171754, 2008, A1. Location in patent: Page/Page column 101; 102
[3] Patent: WO2009/39134, 2009, A1. Location in patent: Page/Page column 179
[4] Patent: WO2006/65215, 2006, A1. Location in patent: Page/Page column 17; 24
[5] Patent: WO2006/65216, 2006, A1. Location in patent: Page/Page column 16; 24
8-bromo-1,2,3,4-tetrahydroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8-bromo-1,2,3,4-tetrahydroisoquinoline manufacturers
- Product
- 8-bromo-1,2,3,4-tetrahydroisoquinoline 75416-51-2
- Price
- US $0.10/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 10g,100g,1kg
- Release date
- 2020-01-14