ChemicalBook > CAS DataBase List > (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid

Product Name
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
CAS No.
80544-17-8
Chemical Name
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
Synonyms
NICA;MICAAcid;Cefixime Impurity 9;Mannitol Impurity 65;Cefixime Impurity 39;Cefixime side chain acid;Cefoxime side chain acid;(Z)-(2-Aminothiazol-4-yl)-;Cefacoxime side chain acid;Cefixime side chain acid( TBKWCLS)
CBNumber
CB2110046
Molecular Formula
C8H9N3O5S
Formula Weight
259.24
MOL File
80544-17-8.mol
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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Property

Melting point:
>160°C (dec.)
Boiling point:
481.1±51.0 °C(Predicted)
Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Refrigerator, under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
2.40±0.10(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A633340
Product name
(Z)-2-(2-Aminothiazol-4-yl)-2-((2-methoxy-2-oxoethoxy)imino)aceticAcid
Packaging
5g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J11545
Product name
CefiximeImpurity1
Packaging
100mg
Price
$98
Updated
2021/12/16
Oakwood
Product number
036575
Product name
(Z)-(2-Aminothiazol-4-yl)methoxycarbonylmethoxyiminoaceticacid
Purity
99%
Packaging
1g
Price
$12
Updated
2021/12/16
Oakwood
Product number
036575
Product name
(Z)-(2-Aminothiazol-4-yl)methoxycarbonylmethoxyiminoaceticacid
Purity
99%
Packaging
5g
Price
$25
Updated
2021/12/16
Oakwood
Product number
036575
Product name
(Z)-(2-Aminothiazol-4-yl)methoxycarbonylmethoxyiminoaceticacid
Purity
99%
Packaging
100g
Price
$265
Updated
2021/12/16
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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Chemical Properties,Usage,Production

Uses

(Z)-2-(2-amino-4-thiazolyl)-2-methoxycarbonylmethoxyiminoacetic acid (cefixime side chain acid) is an important side chain for the synthesis of the third and fourth generation cephalosporins It is of great economic and practical value to strengthen its research and development.

Uses

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid can be used as an intermediate in organic synthesis.

Preparation

The synthesis of cefixime side chain acid takes tert-butyl acetoacetate as raw material, through the steps of oximation, etherification, chlorination, cyclization and hydrolysis, to synthesize (Z)-2-(2-amino Thiazol-4-yl)-2-methoxycarbonylmethoxyiminoacetic acid.

(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid Suppliers

China 124 Germany 1 India 4 United Kingdom 1 United States 11 Global 141
Eurolabs Limited
Tel
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Fax
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Country
United Kingdom
ProdList
6309
Advantage
46
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View Lastest Price from (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid 80544-17-8
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
300 MT
Release date
2020-05-23
Career Henan Chemical Co
Product
(Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid 80544-17-8
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-21

80544-17-8, (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Glycine Ethyl acetate Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) (Z)-2-(TERT-METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID Chloroacetic acid Acetic anhydride Cefixime 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)- (Z)-2-(2-Aminothiazol-4-yl)-2-(tert-butoxycarbonylmethoxyimino)acetic acid Diethyl thiophosphoryl-(Z)-2-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl)isopropoxyiminoacetate (Z)-2-(tert-Butoxycarbonylprop-2-oxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid Ethyl 2-(2-aminothiazole-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxyimino)acetate 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-1,1-DIMETHYL-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH DIETHYL HYDROGEN PHOSPHATE, (Z)- POLY(METHYL METHACRYLATE) ISOTACTIC 4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-[[2-(1,1-DIMETHYLETHOXY)-2-OXOETHOXY]IMINO]-, ANHYDRIDE WITH O,O-DIETHYL HYDROGEN PHOSPHOROTHIOATE (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid (Z)-(METHOXYCARBONYLMETHOXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)ACETIC ACID

  • NICA
  • (Z)-2-Amino-ALPHA-[(2-methoxy-2-oxoethoxy)-imino]-4-thiazoleacetic acid
  • MICAAcid
  • (Z)-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYCARBONYLMETHOXYIMINOACETIC ACID
  • (Z)-2-(Methoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)acetic acid
  • (Z)-2-(2-METHOXY-2-OXOETHOXYIMINO)-2-(2-METHYLTHIAZOL-4-YL)ACETIC ACID
  • (Z)-(2-Aminothiazol-4-yl)-
  • (Z)-2-(2-AMinothiazol-4-yl)-2-((2-Methoxy-2-oxoethoxy)iMino)acetic acid
  • Cefixime side chain acid
  • Cefixime Impurity 9
  • (2-AMINOTHIAZOL-4-YL)-METHOXYCARBONYLMETHOXYIMINOACETIC ACID
  • (2Z)-2-(2-amino-4-thiazolyl)-2-(2-methoxy-2-oxoethoxy)iminoacetic acid
  • (Z)-2-(t-MethoxycarbonylMethoxyimino)-2-(2-Aminothiazol-4-yl)Acetic Acid
  • 4-Thiazoleacetic acid, 2-amino-α-[(2-methoxy-2-oxoethoxy)imino]-, (αZ)-
  • (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-methoxy-2-oxoethoxy)iminoacetic acid
  • (Z)-2-(tert-Methoxycarbonyl Methoxyimino)-2-(2-Aminothiazol-...
  • Cefoxime side chain acid
  • Cefacoxime side chain acid
  • Cefixime side chain acid( TBKWCLS)
  • Mannitol Impurity 65
  • Cefixime Impurity 39
  • 80544-17-8