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CDK5-IN-3

Product Name
CDK5-IN-3
CAS No.
2639542-32-6
Chemical Name
CDK5-IN-3
Synonyms
CDK5-IN-3;(1R)-1-(7-anilino-1,6-naphthyridin-2-yl)-1-(1-methyl-4-piperidinyl)ethanol
CBNumber
CB211077020
Molecular Formula
C22H26N4O
Formula Weight
362.48
MOL File
2639542-32-6.mol
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CDK5-IN-3 Property

Boiling point:
547.3±45.0 °C(Predicted)
Density 
1.219±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 10 mg/mL (27.59 mM; Need ultrasonic)
form 
Solid
pka
12.91±0.29(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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CDK5-IN-3 Chemical Properties,Usage,Production

Uses

CDK5-IN-3 (compound 11) is a potent and selective CDK5 inhibitor, with IC50s of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. CDK5-IN-3 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD)[1].

IC 50

Cdk5/p25: 0.6 nM (IC50); CDK2/CycA: 18 nM (IC50)

References

[1] Discovery and Optimization of Highly Selective Inhibitors of CDK5. J Med Chem. 2022 Feb 24;65(4):3575-3596. DOI:10.1021/acs.jmedchem.1c02069

CDK5-IN-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK5-IN-3 Suppliers

China 9 United States 1 Global 10
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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8000
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Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
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China
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3934
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58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
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China
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4989
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58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
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sales@chemhifuture.com
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China
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2998
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58
TargetMol Chemicals Inc.
Tel
4008200310
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marketing@tsbiochem.com
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China
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24961
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58
Zhengzhou Lingzhiyue Technology Co., LTD
Tel
+86-0371-55074660
Email
Lingzhiyue@aliyun.com
Country
China
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4739
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Zhengzhou Converging Chemical Co. LTD
Tel
0371-53399770 18037166334
Email
2853031800@qq.com
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China
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5891
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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customer_service@efebio.com
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China
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11973
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Aladdin Scientific
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Email
tp@aladdinsci.com
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United States
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52923
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Nantong HI-FUTURE Biology Co., Ltd.
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+undefined18051384581
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sales@chemhifuture.com
Country
China
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3135
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2639542-32-6, CDK5-IN-3Related Search:

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxopropyl)amino]benzoyl]amino]- CDK7-IN-1

  • CDK5-IN-3
  • (1R)-1-(7-anilino-1,6-naphthyridin-2-yl)-1-(1-methyl-4-piperidinyl)ethanol
  • 2639542-32-6