CDK7-IN-1

Product Name: CDK7-IN-1
CAS No.: 1604810-84-5
Chemical Name: CDK7-IN-1
Synonyms: THZ2;CS-1182;CDK7-IN-1;THZ2,CDK7-IN-1;THZ-2;THZ2;THZ 2;inhibit,THZ2,Cyclin dependent kinase,CDK,THZ-2,Inhibitor,THZ 2;(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(4-(dimethylamino)but-2-enamido)benzamide;Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-
CBNumber: CB52715617
Molecular Formula: C31H28ClN7O2
Formula Weight: 566.05
MOL File: 1604810-84-5.mol

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CDK7-IN-1 Property

Density: 1.379±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥28.3 mg/mL in DMSO; insoluble in H2O; ≥2.96 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
pka: 13.06±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-3245
Product name: THZ2
Purity: 99.62%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-3245
Product name: THZ2
Purity: 99.62%
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ApexBio Technology

Product number: A8717
Product name: THZ2
Packaging: 5mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0005710
Product name: (E)-N-(3-((5-CHLORO-4-(1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)PHENYL)-3-(4-(DIMETHYLAMINO)BUT-2-ENAMIDO)BENZAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $502.54
Updated: 2021/12/16

ChemScene

Product number: CS-3245
Product name: THZ2
Purity: 99.62%
Packaging: 50mg
Price: $850
Updated: 2021/12/16

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CDK7-IN-1 Chemical Properties,Usage,Production

Biological Activity

thz2 is a potent and selective cdk7 inhibitor (ic50=13.9 nm).cyclin-dependent kinase (cdk) is a group of serine/threonine kinases. it is activated by binding to cyclin and participates in the regulation of cell cycle.thz2 selectively targets cdk7 and potently blocks the proliferation of triple-negative breast cancer (tnbc) cells and induces apoptotic cell death without causing alteration in cell cycle. the low nanomolar dose of thz2 also inhibits the clonogenic growth of tnbc cells with ic50 of 10 nm.thz2 is well tolerant in mice as 10 mg/kg intraperitoneal treatment of thz2 twice daily does not cause weight loss or behavioral changes. thz2 treatment also significantly reduces the tumor growth rate mice. in addition, both acute (50 hr) or chronic (25 days) exposure to thz markedly decreases ctd phosphorylation of rnapii at all three phosphorylation sites as indication of cdk7 being efficiently targeted.

References

1. wang y, zhang t, kwiatkowski n et al. cdk7-dependent transcriptional addiction in triple-negative breast cancer. cell. 2015 sep 24;163(1):174-86.

CDK7-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK7-IN-1 Suppliers

China 53 United States 7 Global 60

LETOPHARM LIMITED

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Shanghaizehan biopharma technology co., Ltd.

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Guangzhou Zhiya Chemdrugs Co.,Ltd

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SPIRO PHARMA

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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Amadis Chemical Company Limited

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1604810-84-5, CDK7-IN-1Related Search:

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxopropyl)amino]benzoyl]amino]- CDK5-IN-3

CS-1182

THZ-2;THZ2;THZ 2

CDK7-IN-1

THZ2

(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(4-(dimethylamino)but-2-enamido)benzamide

THZ2,CDK7-IN-1

Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-

inhibit,THZ2,Cyclin dependent kinase,CDK,THZ-2,Inhibitor,THZ 2

1604810-84-5