ChemicalBook > CAS DataBase List > CDK7-IN-1

CDK7-IN-1

Product Name
CDK7-IN-1
CAS No.
1604810-84-5
Chemical Name
CDK7-IN-1
Synonyms
THZ2;CS-1182;CDK7-IN-1;THZ2,CDK7-IN-1;THZ-2;THZ2;THZ 2;inhibit,THZ2,Cyclin dependent kinase,CDK,THZ-2,Inhibitor,THZ 2;(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(4-(dimethylamino)but-2-enamido)benzamide;Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-
CBNumber
CB52715617
Molecular Formula
C31H28ClN7O2
Formula Weight
566.05
MOL File
1604810-84-5.mol
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CDK7-IN-1 Property

Density 
1.379±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥28.3 mg/mL in DMSO; insoluble in H2O; ≥2.96 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
13.06±0.70(Predicted)
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-3245
Product name
THZ2
Purity
99.62%
Packaging
5mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-3245
Product name
THZ2
Purity
99.62%
Packaging
10mg
Price
$300
Updated
2021/12/16
ApexBio Technology
Product number
A8717
Product name
THZ2
Packaging
5mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0005710
Product name
(E)-N-(3-((5-CHLORO-4-(1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)PHENYL)-3-(4-(DIMETHYLAMINO)BUT-2-ENAMIDO)BENZAMIDE
Purity
95.00%
Packaging
5MG
Price
$502.54
Updated
2021/12/16
ChemScene
Product number
CS-3245
Product name
THZ2
Purity
99.62%
Packaging
50mg
Price
$850
Updated
2021/12/16
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CDK7-IN-1 Chemical Properties,Usage,Production

Biological Activity

thz2 is a potent and selective cdk7 inhibitor (ic50=13.9 nm).cyclin-dependent kinase (cdk) is a group of serine/threonine kinases. it is activated by binding to cyclin and participates in the regulation of cell cycle.thz2 selectively targets cdk7 and potently blocks the proliferation of triple-negative breast cancer (tnbc) cells and induces apoptotic cell death without causing alteration in cell cycle. the low nanomolar dose of thz2 also inhibits the clonogenic growth of tnbc cells with ic50 of 10 nm.thz2 is well tolerant in mice as 10 mg/kg intraperitoneal treatment of thz2 twice daily does not cause weight loss or behavioral changes. thz2 treatment also significantly reduces the tumor growth rate mice. in addition, both acute (50 hr) or chronic (25 days) exposure to thz markedly decreases ctd phosphorylation of rnapii at all three phosphorylation sites as indication of cdk7 being efficiently targeted.

References

1. wang y, zhang t, kwiatkowski n et al. cdk7-dependent transcriptional addiction in triple-negative breast cancer. cell. 2015 sep 24;163(1):174-86.

CDK7-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK7-IN-1 Suppliers

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1604810-84-5, CDK7-IN-1Related Search:

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxopropyl)amino]benzoyl]amino]- CDK5-IN-3

  • CS-1182
  • THZ-2;THZ2;THZ 2
  • CDK7-IN-1
  • THZ2
  • (E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(4-(dimethylamino)but-2-enamido)benzamide
  • THZ2,CDK7-IN-1
  • Benzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-
  • inhibit,THZ2,Cyclin dependent kinase,CDK,THZ-2,Inhibitor,THZ 2
  • 1604810-84-5