1-Bromo-2-difluoromethoxy-4-fluoro-benzene
- Product Name
- 1-Bromo-2-difluoromethoxy-4-fluoro-benzene
- CAS No.
- 954235-83-7
- Chemical Name
- 1-Bromo-2-difluoromethoxy-4-fluoro-benzene
- Synonyms
- 2-Bromo-alpha,alpha,5-trifluoroanisole;2-(Difluoromethoxy)-4-fluorobromobenzene;1-Bromo-2-difluoromethoxy-4-fluoro-benzene;2-(Difluoromethoxy)-4-fluorobromobenzene 98%;Benzene, 1-bromo-2-(difluoromethoxy)-4-fluoro-
- CBNumber
- CB21113057
- Molecular Formula
- C7H4BrF3O
- Formula Weight
- 241.01
- MOL File
- 954235-83-7.mol
1-Bromo-2-difluoromethoxy-4-fluoro-benzene Property
- Boiling point:
- 185.4±35.0 °C(Predicted)
- Density
- 1.660±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H319Causes serious eye irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B690163
- Product name
- 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC48301
- Product name
- 2-(Difluoromethoxy)-4-fluorobromobenzene
- Purity
- 98%
- Packaging
- 5g
- Price
- $151
- Updated
- 2021/12/16
- Product number
- Z5406
- Product name
- 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene
- Packaging
- 10g
- Price
- $244
- Updated
- 2021/12/16
- Product number
- PC48301
- Product name
- 2-(Difluoromethoxy)-4-fluorobromobenzene
- Purity
- 98%
- Packaging
- 25g
- Price
- $547
- Updated
- 2021/12/16
- Product number
- PC48301
- Product name
- 2-(Difluoromethoxy)-4-fluorobromobenzene
- Purity
- 98%
- Packaging
- 100g
- Price
- $1613
- Updated
- 2021/12/16
1-Bromo-2-difluoromethoxy-4-fluoro-benzene Chemical Properties,Usage,Production
Synthesis
1895-39-2
147460-41-1
954235-83-7
General procedure for the synthesis of 1-bromo-2-(difluoromethoxy)-4-fluorobenzene from sodium difluorochloroacetate and 2-bromo-5-fluorophenol: 1. to a solution of 2-bromo-5-fluorophenol (3 g, 15.7 mmol) in DMF (5 ml) was added cesium carbonate (7.7 g, 23.56 mmol, 1.5 eq.) and sodium difluorochloroacetate (6 g, 39.26 mmol, 2.5 eq.). 2. The reaction mixture was heated and stirred at 100 °C for 15 hours. 3. After completion of the reaction, the reaction was terminated with water and ethyl acetate (3 x 50 ml). 4. The organic layer was separated, washed with water and brine, and then dried over anhydrous sodium sulfate. 5. The solvent was removed by pressurized distillation to obtain the crude product. 6. The crude product was purified by column chromatography (silica gel 60-120, eluent: 10% hexane solution of ethyl acetate) in 58% (2.2 g) yield.
References
[1] Patent: WO2014/162039, 2014, A1. Location in patent: Page/Page column 41
[2] Patent: EP2394987, 2011, A1. Location in patent: Page/Page column 9
[3] Patent: WO2012/143329, 2012, A1. Location in patent: Page/Page column 121
1-Bromo-2-difluoromethoxy-4-fluoro-benzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Bromo-2-difluoromethoxy-4-fluoro-benzene manufacturers
- Product
- 1-Bromo-2-difluoromethoxy-4-fluoro-benzene 954235-83-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-17