ChemicalBook > CAS DataBase List > 3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid

3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid

Product Name
3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid
CAS No.
272437-84-0
Chemical Name
3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid
Synonyms
SBB007498;SMR000278331;BAS 13090967;MLS000716814;Oprea1_286767;CBDivE_002679;AN-829/25059005;3-oxo-4H-1,4-benzothiazine-6-carboxylic acid;3-keto-4H-1,4-benzothiazine-6-carboxylic acid;6-Carboxy-3,4-dihydro-3-oxo-2H-1,4-benzothiazine
CBNumber
CB21117484
Molecular Formula
C9H7NO3S
Formula Weight
209.22
MOL File
272437-84-0.mol
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3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid Property

Boiling point:
483.9±45.0 °C(Predicted)
Density 
1.485±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
3.82±0.20(Predicted)
Appearance
White to yellow Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
O991888
Product name
3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylicAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
033883
Product name
3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid
Packaging
500mg
Price
$50
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
COR0002372
Product name
3,4-DIHYDRO-3-OXO-2H-BENZO[B][1,4]THIAZINE-6-CARBOXYLIC ACID
Purity
95.00%
Packaging
500MG
Price
$219.35
Updated
2021/12/16
Matrix Scientific
Product number
033883
Product name
3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid
Packaging
1g
Price
$77
Updated
2021/12/16
AK Scientific
Product number
W5031
Product name
3-Oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylicacid
Packaging
1g
Price
$153
Updated
2021/12/16
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3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid Chemical Properties,Usage,Production

Synthesis

204863-53-6

272437-84-0

The general procedure for the synthesis of 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid from ethyl 3-oxo-4H-1,4-benzothiazine-6-carboxylate was as follows: to a solution of tetrahydrofuran (THF, 30 mL) of ethyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate (5.1 g, 21 mmol), 1 N aqueous sodium hydroxide solution (100 mL). The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction solution was acidified with 1 N hydrochloric acid and subsequently extracted with ethyl acetate. The organic phases were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was recrystallized with diisopropyl ether to give the title compound as white crystals (3.65 g, 83% yield).1H NMR (300 MHz, DMSO-d6) δ: 3.26 (br, 1H), 3.48 (s, 2H), 7.34-7.51 (m, 3H), 10.69 (br, 1H).

References

[1] Patent: WO2004/46107, 2004, A1. Location in patent: Page 213

3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid Suppliers

China 35 India 2 United Kingdom 1 United States 8 Global 46
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272437-84-0, 3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acidRelated Search:

2-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLIC ACID 4-(4-OXO-PIPERIDINE-1-CARBONYL)-BENZAMIDE METHYL 4-BENZYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE 4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLIC ACID 3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid METHYL 4-ETHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE METHYL 3-OXO-4-[3-(TRIFLUOROMETHYL)BENZYL]-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE METHYL 4-(2,4-DICHLOROBENZYL)-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE METHYL 4-(3-CHLOROBENZYL)-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE METHYL 4-METHYL-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE Methyl 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylate METHYL 4-(4-CHLOROBENZYL)-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOTHIAZINE-6-CARBOXYLATE

  • 6-Carboxy-3,4-dihydro-3-oxo-2H-1,4-benzothiazine
  • AN-829/25059005
  • BAS 13090967
  • CBDivE_002679
  • MLS000716814
  • Oprea1_286767
  • SBB007498
  • SMR000278331
  • 3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxylic acid
  • 2H-1,4-Benzothiazine-6-carboxylic acid, 3,4-dihydro-3-oxo-
  • 3-Oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid
  • 3,4-Di hydro-3-oxo-2h-benzo[1,4]thiazin-6-carboxylic acid
  • 3-keto-4H-1,4-benzothiazine-6-carboxylic acid
  • 3-oxo-4H-1,4-benzothiazine-6-carboxylic acid
  • JR-8616, 3,4-Dihydro-3-oxo-2H-benzo[b][1,4]thiazine-6-carboxylic acid, 97%
  • 272437-84-0