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Dicirenone

Product Name
Dicirenone
CAS No.
41020-79-5
Chemical Name
Dicirenone
Synonyms
SC 26304;Dicirenone;(17R)-17-Hydroxy-3-oxo-7α-(isopropyloxycarbonyl)pregn-4-ene-21-carboxylic acid γ-lactone;Pregn-4-ene-7,21-dicarboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, 1-methylethyl ester, (7α,17α)-
CBNumber
CB21117929
Molecular Formula
C26H36O5
Formula Weight
428.565
MOL File
41020-79-5.mol
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Dicirenone Property

Boiling point:
579.3±50.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D437740
Product name
Dicirenone
Packaging
5mg
Price
$580
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0000691
Product name
(2'R,7R,8R,9S,10R,13S,14S)-ISOPROPYL 10,13-DIMETHYL-3,5'-DIOXO-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-HEXADECAHYDRO-3'H-SPIRO[CYCLOPENTA[A]PHENANTHRENE-17,2'-FURAN]-7-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$495.31
Updated
2021/12/16
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Dicirenone Chemical Properties,Usage,Production

Uses

Hypotensive; aldosterone antagonist.

Uses

Dicirenone is employed in the studies of the agonist and antimineralocorticoid activities of spirolactones.

Definition

ChEBI: Dicirenone is a steroid lactone.

in vivo

Cytoplasmic binding of [3H]Aldosterone and [3H]Dicirenone is similar in magnitude and involves the same set of sites. Under three sets of conditions-(i) in the intact rat, (ii) in kidney slices, and (iii) in reconstitution studies (mixing prelabeled cytoplasm with either purified renal nuclei or chromatin), [3H]Dicirenone does not yield specific nuclear complexes in contrast to the reproducible generation of these complexes with [3H]Aldosterone. In glycerol density gradients, cytoplasmic [3H]Aldosterone receptor complexes sediment at 8.5 S and 4 S in low concentrations of salt and at 4.5 S in high concentrations of salt. Cytoplasmic [3H]Dicirenone receptor complexes sediment at 3 S in low concentrations of salt and 4 S in high concentrations of salt. These results are discussed in terms of an allosteric model of the receptor system. Administration of Dicirenone (SC-26304) alone in doses of 3-600 μg/100 g of body weight has no effect on urinary Na+:creatinine or K+:creatinine ratios. These results are expressed as urinary K+:Na+ ratios. Aldosterone (0.3 μg/100 g of body weight) increases the K+:Na+ ratio 5-fold. This increase is significantly inhibited by 180 μg/100 g of body weight of Dicirenone and completely inhibit by 600 μg/100 g of body weight. To correlate inhibitory action and receptor occupancy, the same doses of Dicirenone are given to rats injected with 0.036 μg of [3H]Aldosterone. A dose of 180 μg of body weight reduces specific binding of Aldosterone in cytoplasmic and nuclear fractions to less than half of the control levels and 600 μg/100 g of body weight eliminated specific binding. The dose of Aldosterone used in the physiological studies is about eight times that used in the binding studies, but both doses are well below saturating amounts[1].

Dicirenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Dicirenone Suppliers

China 10 United Kingdom 1 United States 7 USA 1 Global 19
MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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Career Henan Chemica Co
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+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
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29757
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TargetMol Chemicals Inc.
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4008200310
Email
marketing@tsbiochem.com
Country
China
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24961
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RD International Technology Co., Limited
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18024082417
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market@ubiochem.com
Country
China
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9835
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Sangon Biotech (Shanghai) Co.,Ltd.
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400-821-026
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Sales@sangon.com
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China
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6710
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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China
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6051
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TargetMol Chemicals Inc.
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+17819995354
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marketing@targetmol.com
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United States
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19962
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
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41020-79-5, DicirenoneRelated Search:

Dicirenone HEXADECANEDIOIC ACID Bolasterone Tetradecanedioic acid Dihydrojasmone lactone 17-Methyltestosterone topterone METHOXYMELONAL ETHYL CYCLOHEXYLACETATE 1,11-Undecanedicarboxylic acid Azelaic acid Undecanedioic acid AZELAIC ACID MONOMETHYL ESTER Testosterone propionate ETHYL 3,5,5-TRIMETHYLHEXANOATE (S)-4-NONANOLIDE STANDARD FOR GC (S)-4-DODECANOLIDE STANDARD FOR GC (S)-4-UNDECANOLIDE STANDARD FOR GC

  • Dicirenone
  • (17R)-17-Hydroxy-3-oxo-7α-(isopropyloxycarbonyl)pregn-4-ene-21-carboxylic acid γ-lactone
  • SC 26304
  • Pregn-4-ene-7,21-dicarboxylic acid, 17-hydroxy-3-oxo-, γ-lactone, 1-methylethyl ester, (7α,17α)-
  • 41020-79-5
  • C26H36O5