ChemicalBook > CAS DataBase List > 2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE

2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE

Product Name
2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE
CAS No.
22972-63-0
Chemical Name
2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE
Synonyms
3,5-Dimethoxy-α,α-dimethylbenzeneacetonitrile;2-(3,5-diMethoxyphenyl)-2-Methylpropanenitrile;Benzeneacetonitrile, 3,5-dimethoxy-α,α-dimethyl-;2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE
CBNumber
CB21118845
Molecular Formula
C12H15NO2
Formula Weight
205.253
MOL File
22972-63-0.mol
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2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE Property

Boiling point:
324.4℃
Density 
1.039
Flash point:
118.9℃
storage temp. 
Sealed in dry,Room Temperature
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
3017CR
Product name
2-(3,5-Dimethoxyphenyl)-2-methylpropanenitrile
Packaging
1g
Price
$115
Updated
2021/12/16
AK Scientific
Product number
3017CR
Product name
2-(3,5-Dimethoxyphenyl)-2-methylpropanenitrile
Packaging
250mg
Price
$82
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018709
Product name
2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE
Purity
95.00%
Packaging
5G
Price
$1328.25
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018709
Product name
2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE
Purity
95.00%
Packaging
10G
Price
$1963.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018709
Product name
2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE
Purity
95.00%
Packaging
25G
Price
$2887.5
Updated
2021/12/16
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2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE Chemical Properties,Usage,Production

Synthesis

13388-75-5

74-88-4

22972-63-0

Under argon protection, 3,5-dimethoxyphenylacetonitrile (10 g, 56.43 mmol) was dissolved in anhydrous DMF (280 mL) with iodomethane (10.5 mL) and added dropwise through a cannula to a suspension of sodium hydride (4.06 g, 169.20 mmol) in DMF (30 mL) that was pre-cooled to 0 °C. After dropwise addition, the reaction mixture was slowly warmed to room temperature and stirring was continued for 1.5 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution and subsequently diluted with ether. The organic layer was separated and the aqueous phase was further extracted with ether. All organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The residue was purified by fast column chromatography on silica gel, the eluent being a hexane solution of 10-30% ethyl acetate to afford the target product 2-(3,5-dimethoxyphenyl)-2-methylpropanenitrile (11.3 g, 98% yield) as a viscous oil.1H NMR (500 MHz, CDCl3) δ 6.61 (d, J=2.0Hz, 2H, ArH), δ 6.27 (t, J=2.0Hz, 1H, ArH), 3.81 (s, 6H, OCH3), 1.70 (s, 6H, C(CH3)2).

References

[1] Patent: WO2014/62965, 2014, A1. Location in patent: Paragraph 0177
[2] Organic and Biomolecular Chemistry, 2017, vol. 15, # 9, p. 2086 - 2096
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 24, p. 10142 - 10157
[4] Nature, 2017, vol. 547, # 7664, p. 468 - 471
[5] Patent: US2008/249137, 2008, A1. Location in patent: Page/Page column 45-46

2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE Suppliers

China 11 India 1 Switzerland 1 United States 4 Global 17
Changzhou Chemscaler Pharmtech Co., Ltd.
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0519-81096292 15312577869
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chemscaler@yahoo.com.cn
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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Aikon International Limited
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025-66113011 13155353615
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(7)02557626880
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qzhang@aikonchem.com
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China
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Zhejiang Lianshuo Biotechnology Co., Ltd.
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18616526224
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China
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-025-85560043 17301488900
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Energy Chemical
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Biosynth Biological Technology (Suzhou) Co Ltd
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51288865780
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sales@biosynth.com
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China
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Santa Cruz Biotechnology Inc
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021-60936350
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scbt@scbt.com
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China
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DAYANG CHEM (HANGZHOU) CO.,LTD
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+86-88938639 +86-17705817739
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info@dycnchem.com
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China
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Absin Bioscience Inc.
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CHINA
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Shanghai FWD Chemicals Co., Ltd.
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22972-63-0, 2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE Related Search:

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  • 2-(3,5-DIMETHOXY-PHENYL)-2-METHYL-PROPIONITRILE
  • 2-(3,5-diMethoxyphenyl)-2-Methylpropanenitrile
  • Benzeneacetonitrile, 3,5-dimethoxy-α,α-dimethyl-
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  • 22972-63-0