(S)-(-)HYDROXYMETHYL-3(2H)-FURANONE Property

Melting point:

41-43 °C(lit.)

Boiling point:

173.58°C (rough estimate)

Density 

1.2583 (rough estimate)

refractive index 

1.4630 (estimate)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly), Water (Sparingly)

form 

Solid

pka

13.51±0.10(Predicted)

color 

Off-White

optical activity

[α]20/D 144°, c = 1 in H2O

Water Solubility 

Slightly soluble in water.

Sensitive 

Hygroscopic

BRN 

3537455

Stability:

Moisture Sensitive

LogP

-1.810 (est)

CAS DataBase Reference

78508-96-0(CAS DataBase Reference)

Safety

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-10

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

(S)-(-)HYDROXYMETHYL-3(2H)-FURANONE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(S)-(-)-5-Hydroxymethyl-2(5H)-furanone is used in the preparation of partially saturated heterocycles via a diastereoselective ring chain formation. It is also used in the synthesis of (1R,3S)-cis-chrysanthemic acid.

Uses

(S)-(?)-5-Hydroxymethyl-2(5H)-furanone can be used as a starting material in the preparation of:

• Partially saturated heterocycles via a diastereoselective ring chain formation.
• A natural product named (+)-muscarine.
• 3′-Ethynylthymidine as a possible antiviral agent.