3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
- Product Name
- 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
- CAS No.
- 218137-86-1
- Chemical Name
- 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
- Synonyms
- C75;C75（218137-86-1）;C75, 10 mM in DMSO;FAS inhibitor C75 (C-75;C75 >=98% (HPLC), powder;3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE;TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE;3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-;C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid);TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID
- CBNumber
- CB2114165
- Molecular Formula
- C14H22O4
- Formula Weight
- 254.32
- MOL File
- 218137-86-1.mol
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Property
- Boiling point:
- 432.1±45.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 18 mg/mL
- form
- solid
- pka
- 3.08±0.40(Predicted)
- color
- off-white
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C5490
- Product name
- C75
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $354.35
- Updated
- 2025/07/31
- Product number
- C5490
- Product name
- C75
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $1430
- Updated
- 2025/07/31
- Product number
- 2489
- Product name
- C75
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 254848
- Product name
- C 75
- Packaging
- 10mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CS-3562
- Product name
- C75
- Purity
- 99.91%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Chemical Properties,Usage,Production
Uses
C75 has been used:
- as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
- as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
- as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide
Definition
ChEBI: 4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic acid is a gamma-lactone.
Biochem/physiol Actions
C75 helps to increase the cancer‐killing capability of ionizing radiation.
in vivo
C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection[3]. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA[4].
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Suppliers
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