3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE

Product Name: 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
CAS No.: 218137-86-1
Chemical Name: 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
Synonyms: C75;FAS inhibitor C75 (C-75;C75 >=98% (HPLC), powder;3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE;TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE;3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-;C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid);TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID
CBNumber: CB2114165
Molecular Formula: C14H22O4
Formula Weight: 254.32
MOL File: 218137-86-1.mol

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3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Property

Boiling point:: 432.1±45.0 °C(Predicted)
Density: 1.08±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 18 mg/mL
form: solid
pka: 3.08±0.40(Predicted)
color: off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5490
Product name: C75
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $345
Updated: 2024/03/01

Sigma-Aldrich

Product number: C5490
Product name: C75
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $1390
Updated: 2024/03/01

Tocris

Product number: 2489
Product name: C75
Purity: ≥99%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

Usbiological

Product number: 254848
Product name: C 75
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-3562
Product name: C75
Purity: 99.91%
Packaging: 50mg
Price: $842
Updated: 2021/12/16

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3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Chemical Properties,Usage,Production

Uses

C75 has been used:

as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Definition

ChEBI: 4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic acid is a gamma-lactone.

Biochem/physiol Actions

C75 helps to increase the cancer‐killing capability of ionizing radiation.

3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE Suppliers

China 41 Switzerland 1 United States 14 Global 56

AdooQ BioScience, LLC

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Jiaxing Novartis Chemical Co., Ltd.

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LETOPHARM LIMITED

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Sigma-Aldrich

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Amadis Chemical Company Limited

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Musechem

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TargetMol Chemicals Inc.

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DC Chemicals

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218137-86-1, 3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONERelated Search:

BUTTPARK 27\04-75 BUTTPARK 4\01-75 BUTTPARK 30\09-75 BUTTPARK 23\07-75 BUTTPARK 32\01-75 BUTTPARK 35\03-75 BUTTPARK 31\08-75 BUTTPARK 43\57-75 BUTTPARK 33\08-75 BUTTPARK 18\01-75 BUTTPARK 153\33-75 BUTTPARK 34\07-75 BUTTPARK 37\11-75 BUTTPARK 29\09-75 16:0 PC D75 BUTTPARK 16\04-75 BUTTPARK 26\07-75 BUTTPARK 152\40-75

3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE

C75

C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid)

TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE

TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID

FAS inhibitor C75 (C-75

3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-

C75 >=98% (HPLC), powder

218137-86-1

Fatty acid synthase

Enzyme Inhibitors by Enzyme

Enzymes, Inhibitors, and Substrates

D to K

Enzyme Inhibitors

Biochemicals and Reagents

BioChemical