ChemicalBook > CAS DataBase List > ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
- Product Name
- ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
- CAS No.
- 17159-80-7
- Chemical Name
- ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
- Synonyms
- ethyl 4-hydroxycyclohexane-1-carboxylate;Ai3-28355;Einecs 241-215-1;4-Hydroxycyclohexanecarboxylate;Ethyl 4-hydroxycyclohexanecarbonate;Ethyl 4-hydroxycyclohexylcarboxylate;ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE;Ethyl4-hydroxycyclohexanecarboxylate,98%;Ethyl 4-hydroxycyclohexanecarboxylate 97%;Ethyl 4-hydroxycyclohexanecarboxylate≥ 99% (assay)
- CBNumber
- CB2114589
- Molecular Formula
- C9H16O3
- Formula Weight
- 172.22
- MOL File
- 17159-80-7.mol
More
Less
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Property
- Boiling point:
- 127-134 °C0.1 mm Hg(lit.)
- Density
- 1.068 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.466(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- liquid
- pka
- 14.98±0.40(Predicted)
- Specific Gravity
- 1.068
- Appearance
- Colorless to light yellow Liquid
- Water Solubility
- Not miscible or difficult to mix in water.
- InChI
- InChI=1S/C9H16O3/c1-2-12-9(11)7-3-5-8(10)6-4-7/h7-8,10H,2-6H2,1H3
- InChIKey
- BZKQJSLASWRDNE-UHFFFAOYSA-N
- SMILES
- C1(C(OCC)=O)CCC(O)CC1
- CAS DataBase Reference
- 17159-80-7
More
Less
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 386634
- Product name
- Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans
- Purity
- 98%
- Packaging
- 5ml
- Price
- $80.18
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 386634
- Product name
- Ethyl 4-hydroxycyclohexanecarboxylate, mixture of cis and trans
- Purity
- 98%
- Packaging
- 25ml
- Price
- $262.2
- Updated
- 2025/07/31
TRC
- Product number
- E945580
- Product name
- Ethyl4-Hydroxycyclohexanecarboxylate
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
Oakwood
- Product number
- 092690
- Product name
- Ethyl4-hydroxycyclohexanecarboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $20
- Updated
- 2021/12/16
AK Scientific
- Product number
- J94765
- Product name
- Ethyl4-hydroxycyclohexanecarboxylate
- Packaging
- 100g
- Price
- $225
- Updated
- 2021/12/16
More
Less
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Chemical Properties,Usage,Production
Uses
Ethyl 4-hydroxycyclohexanecarboxylate, cis + trans is used in the synthesis of other chemicals and as pharmaceutical intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 4145, 1965 DOI: 10.1021/jo01023a039
Synthesis
17159-79-4
3618-04-0
General procedure for the synthesis of ethyl trans-4-hydroxycyclohexanecarboxylate from ethyl 4-oxocyclohexanecarboxylate: ethyl 4-oxocyclohexanecarboxylate (13.5 g, 79 mmol) was dissolved in methanol (150 mL) at 0 °C and sodium borohydride (5.3 g, 140 mmol) was added slowly. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL), followed by extraction with ethyl acetate (150 mL x 1, 50 mL x 2). The organic layers were combined, washed with water (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, ratio 1.5:1 to 1:1) to afford ethyl 4-hydroxycyclohexanecarboxylate (12 g, 88% yield, cis-trans ratio = 3:7) as a clear oil.1H NMR (300 MHz, CDCl3, cis mixture) δ: 4.17-4.08 (m, 2H), 3.90 (bs. 0.3H), 3.68-3.57 (m, 0.7H), 2.42-1.28 (m, 9H), 1.27-1.22 (m, 3H) ppm.(Hydroxyl signal was not observed.)
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 19, p. 8967 - 9004
[2] Organic Process Research and Development, 2010, vol. 14, # 4, p. 883 - 889
[3] Patent: WO2005/80317, 2005, A2. Location in patent: Page/Page column 150
[4] Tetrahedron Letters, 2000, vol. 41, # 39, p. 7567 - 7570
[5] Patent: US5175290, 1992, A
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE Suppliers
- Tel
- 523-86810021 18921709486
- Fax
- gwli@elitechemie.com
- gwli@elitechemie.com
- Country
- China
- ProdList
- 509
- Advantage
- 65
- Tel
- 13720451009
- 13720451009@163.com
- Country
- China
- ProdList
- 182
- Advantage
- 58
- Tel
- 27-87509949 13419524390
- sdg9136@163.com
- Country
- China
- ProdList
- 118
- Advantage
- 58
- Tel
- 15005516438
- Fax
- 15005516438
- sales1@qiushipharm.com
- Country
- China
- ProdList
- 82
- Advantage
- 58
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 021-61995394 18916691159
- chemicalsea@163.com
- Country
- China
- ProdList
- 1972
- Advantage
- 58
- Tel
- 0514-015380367604 15380367604
- Fax
- 0514-83828236
- sales@ruibobiotech.com
- Country
- China
- ProdList
- 511
- Advantage
- 55
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14912
- Advantage
- 59
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 021-60455363 18019463053
- Fax
- 50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12346
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 0523-86132544 15366717810
- Fax
- 0523-86201489
- sales@thbiochem.com
- Country
- China
- ProdList
- 375
- Advantage
- 55
- Tel
- 028-85434334 18108076537
- Fax
- QQ：245797092
- market@gianthx.com
- Country
- China
- ProdList
- 4505
- Advantage
- 56
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7991
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 15716293042 18862996710
- Fax
- 0513-68015394
- 15050603958@163.com
- Country
- China
- ProdList
- 695
- Advantage
- 55
- Tel
- 021-50908862，442785678，326799392 18721037013
- Fax
- 021-50908862
- siyansales@126.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
- Tel
- 021-52907766-8042
- Fax
- 021-52906523
- Country
- China
- ProdList
- 9941
- Advantage
- 58
- Tel
- 052386810091
- zcwy9518@yeah.net
- Country
- China
- ProdList
- 3912
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 0371-55289822 18737195735
- Fax
- QQ：2370407954
- 2370407954@qq.com
- Country
- China
- ProdList
- 1981
- Advantage
- 55
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10110
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-52343882 18112933882
- Fax
- 025-52343882
- sales@kldbio.com
- Country
- China
- ProdList
- 2019
- Advantage
- 55
- Tel
- 18800375331
- Fax
- 021-50908862
- kangmansales@163.com
- Country
- China
- ProdList
- 7570
- Advantage
- 55
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 021-37581181
- Fax
- 021-57456066
- sales@chem-mall.com
- Country
- China
- ProdList
- 10330
- Advantage
- 58
More
Less
View Lastest Price from ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE manufacturers
HANGZHOU HAILAN CHEMICAL CO.,LTD.
- Product
- ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE 17159-80-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-09-08
HANGZHOU HAILAN CHEMICAL CO.,LTD.
- Product
- ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE 17159-80-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-09-08
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- Ethyl 4-hydroxycyclohexanecarboxylate 17159-80-7
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-24
17159-80-7, ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATERelated Search:
22(S),23(S)-HOMOBRASSINOLIDE
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate
Brassinolide
ETHYL 4-HYDROXYCYCLOHEXANECARBOXYLATE
Homobrassinolide
4-Hydroxycyclohexanecarboxylic acid
22S,23S-EPIBRASSINOLIDE
ethyl 3-hydroxycyclohexanecarboxylate
ETHYL 2-HYDROXYCYCLOHEXANECARBOXYLATE
SALOR-INT L152536-1EA
AKOS B024701
AKOS B024699
3,4-EPOXY-6-METHYLCYCLOHEXYLMETHYL-3,4-EPOXY-6-METHYLCYCLOHEXANECARBOXYLATE
SALOR-INT L152544-1EA
DIETHYL 2-(BENZO[D][1,3]DIOXOL-5-YL)-4-HYDROXY-4-METHYL-6-OXOCYCLOHEXANE-1,3-DICARBOXYLATE
ETHYL 8-(BROMOMETHYL)-1,4-DIOXASPIRO[4.5]DECANE-8-CARBOXYLATE
DIETHYL 2-(4-ETHOXYPHENYL)-4-HYDROXY-4-METHYL-6-OXOCYCLOHEXANE-1,3-DICARBOXYLATE
AKOS BC-1751