CERIVASTATIN SODIUM
- Product Name
- CERIVASTATIN SODIUM
- CAS No.
- 145599-86-6
- Chemical Name
- CERIVASTATIN SODIUM
- Synonyms
- BAYCOL;LIPOBAY;RIVASTATIN;Cerivastatin;CERIVASTATIN NA;CERIVASTATIN, SODIUM SALT;Cerivastatin See C277000;CERIVASTATIN SODIUM USP/EP/BP;7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate;6-[2-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)-3-pyridinyl]ethenyl]-4-hydroxy-2-oxanone
- CBNumber
- CB2115263
- Molecular Formula
- C26H34FNO5
- Formula Weight
- 459.55
- MOL File
- 145599-86-6.mol
CERIVASTATIN SODIUM Property
- Melting point:
- >176oC (dec.)
- Boiling point:
- 646.3±55.0 °C(Predicted)
- Density
- 1.181±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- pka
- pKa 4.38 (H2O t=25 I=0.025) (Uncertain);5.29(H2O t=25 I=0.025) (Uncertain)
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 145599-86-6(CAS DataBase Reference)
- EPA Substance Registry System
- 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1- methylethyl)-3-pyridinyl]-3,5-dihydroxy-, (3R,5S,6E)- (145599-86-6)
Safety
- Hazardous Substances Data
- 145599-86-6(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- C2830
- Product name
- Cerivastatin, Sodium Salt
- Packaging
- 5mg
- Price
- $396
- Updated
- 2021/12/16
- Product number
- MT-49111
- Product name
- Cerivastatin
- Purity
- 98%
- Packaging
- 0.1g
- Price
- $410
- Updated
- 2021/12/16
CERIVASTATIN SODIUM Chemical Properties,Usage,Production
Uses
assimilate cholesterol
Definition
ChEBI: (3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cho esterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.
brand name
Baycol (Bayer);Cholstat.
in vivo
Cerivastatin is well absorbed, reaching maximal plasma levels in 1-3 hours following oral dosing. In the circulation, Cerivastatin is highly bound to plasma proteins (99.5%), with an elimination half-life of 2-4 hours. Cerivastatin is metabolized predominantly in the liver to three polar metabolites. Two of these metabolites are active, but to a lesser extent compared to parent drug, and the third metabolite is inactive. Plasma concentrations of all metabolites are substantially lower than those of the parent drug. Elimination of metabolites is via the urine (20-25%) and feces (66-73%), while essentially no parent compound is excreted[2].
CERIVASTATIN SODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
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