ChemicalBook > CAS DataBase List > 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID

2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID

Product Name
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
CAS No.
74356-36-8
Chemical Name
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
Synonyms
ASISCHEM C71549;CHEMBRDG-BB 4019260;TIMTEC-BB SBB010333;ASINEX-REAG BAS 07567148;2,4-dimethylpyrimidine-5-carboxylicaci;2,4-dimethyl-5-pyrimidinecarboxylic acid;2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID;5-Pyrimidinecarboxylic acid, 2,4-dimethyl-;5-Pyrimidinecarboxylicacid,2,4-dimethyl-(6CI,9CI);2,4-dimethylpyrimidine-5-carboxylic acid(SALTDATA: FREE)
CBNumber
CB2117232
Molecular Formula
C7H8N2O2
Formula Weight
152.15
MOL File
74356-36-8.mol
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2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Property

Melting point:
154-155 °C(Solv: ethyl acetate (141-78-6))
Boiling point:
299.6±20.0 °C(Predicted)
Density 
1.257±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
2.62±0.25(Predicted)
Appearance
White to yellow Solid
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D502863
Product name
2,4-dimethylpyrimidine-5-carboxylicacid
Packaging
100mg
Price
$90
Updated
2021/12/16
TRC
Product number
D502863
Product name
2,4-dimethylpyrimidine-5-carboxylicacid
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD116666
Product name
2,4-Dimethylpyrimidine-5-carboxylic acid
Packaging
2g
Price
$434
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0093828
Product name
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
Purity
95.00%
Packaging
0.5G
Price
$682
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0093828
Product name
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
Purity
95.00%
Packaging
1G
Price
$750.75
Updated
2021/12/16
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2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

2226-86-0

74356-36-8

The general procedure for the synthesis of 2,4-dimethylpyrimidine-5-carboxylic acid from ethyl 2,4-dimethylpyrimidine-5-carboxylate was as follows: potassium hydroxide (67 g, 1.0 mol) was dissolved in 95% ethanol (300 mL), and this solution was then added to a 95% ethanol (100 mL) solution of ethyl 2,4-dimethyl-5-pyrimidinecarboxylate (73 g, 0.40 mol) to the solution. The mixture was heated under reflux conditions for 5 hours. Upon completion of the reaction, the ethanol was removed by evaporation under reduced pressure, the residue was dissolved in water and the aqueous solution was acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration, washed with water and dried to give 2,4-dimethylpyrimidine-5-carboxylic acid (36 g, 58% yield). The product was characterized by 1H-NMR (CDCl3), δ: 2.63 (3H, s), 2.69 (3H, s), 8.97 (1H, s).

References

[1] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 295 - 305
[2] Patent: EP1402900, 2004, A1
[3] Patent: EP1364949, 2003, A1. Location in patent: Page/Page column 100
[4] Chemistry of Heterocyclic Compounds, 2007, vol. 43, # 11, p. 1479 - 1480
[5] Patent: EP2019099, 2009, A1. Location in patent: Page/Page column 15-16

2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Acetamidine hydrochloride p-Toluenesulfonic acid Toluene Sodium ethoxide Tetrahydrofuran Ethyl acetate Hydrochloric acid Methanol Sodium hydroxide N,N-Dimethylformamide dimethyl acetal Magnesium sulfate

Preparation Products

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View Lastest Price from 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID manufacturers

Dideu Industries Group Limited
Product
2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID 74356-36-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-07
Career Henan Chemical Co
Product
2,4-dimethylpyrimidine-5-carboxylic acid 74356-36-8
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-09

74356-36-8, 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACIDRelated Search:

4-METHYL-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID 2-(2-PYRIDINYL)-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLIC ACID ETHYL 2-METHYL-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLATE ETHYL 2-(2-PYRIDINYL)-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLATE ETHYL-2,4-DIMETHYL-5-PYRIMIDINE CARBOXYLATE 2-METHYL-4-PHENYL-5-PYRIMIDINECARBOXYLIC ACID ETHYL 2-PHENYL-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLATE 2-PHENYL-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLIC ACID BUTTPARK 86\18-12 4-AMINO-2,6-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER METHYL-2-PHENYL-4-METHYL-5-PYRIMIDINE CARBOXYLATE BUTTPARK 46\18-12 2,4-DIPHENYL-5-PYRIMIDINECARBOXYLIC ACID ETHYL 4-AMINO-6-METHYL-2-(5-METHYL-4-(4-METHYLPIPERAZIN-1-YL)-2-PHENYLTHIENO[2,3-D]PYRIMIDIN-6-YL)PYRIMIDINE-5-CARBOXYLATE BUTTPARK 46\18-15 BUTTPARK 46\18-13 ETHYL 4-AMINO-2-(4-(4,6-DIMETHYLPYRIMIDIN-2-YLAMINO)-5-METHYL-2-PHENYLTHIENO[2,3-D]PYRIMIDIN-6-YL)-6-METHYLPYRIMIDINE-5-CARBOXYLATE 1-AMINO-3-PHENYL-9-OXA-2,4-DIAZA-PHENANTHREN-10-ONE

  • CHEMBRDG-BB 4019260
  • ASISCHEM C71549
  • ASINEX-REAG BAS 07567148
  • 5-Pyrimidinecarboxylicacid,2,4-dimethyl-(6CI,9CI)
  • TIMTEC-BB SBB010333
  • 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID
  • 2,4-dimethyl-5-pyrimidinecarboxylic acid
  • 2,4-dimethylpyrimidine-5-carboxylic acid(SALTDATA: FREE)
  • 2,4-dimethylpyrimidine-5-carboxylicaci
  • 2,4-DIMETHYL-PYRIMIDINE-5-CARBOXYLIC ACID ISO 9001：2015 REACH
  • 5-Pyrimidinecarboxylic acid, 2,4-dimethyl-
  • 74356-36-8
  • Pyrazines, Pyrimidines & Pyridazines
  • Pyrimidine
  • CARBOXYLICACID
  • pharmacetical
  • Pyrimidine series
  • Carboxylic Acids
  • Pyrazines, Pyrimidines & Pyridazines
  • Carboxylic Acids